Prognostic Value of the AMR Measured After PPCI in STEMI Patients

Sponsor

Henan Institute of Cardiovascular Epidemiology (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05653765

Collaborator

(none)

3,000

Enrollment

Locations

Anticipated Duration (Months)

1500

Patients Per Site

100.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The goal of this observational study is to learn about in STEMI with Primary PCI Patients.

The main questions it aims to answer are:

To determine the value of AMR in predicting the long-term clinical prognosis of patients with STEMI after PPCI, and to find the best cut-off value.
Analyze the factors of PPCI affecting AMR and explore the effective measures of PPCI microcirculation protection.

Radiographic images of STEMI receiving primary PCI treatment in several chest pain centers in China will be included. The last image of the infarct-related vessel will be used as a target to calculate its AMR. The relationship between AMR and long-term clinical prognosis was analyzed.

Condition or Disease	Intervention/Treatment	Phase
Coronary Heart Disease ST Elevation Myocardial Infarction

Study Design

Study Type:

Observational

Anticipated Enrollment :

3000 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

Prognostic Value of the Angio-based Microvascular Resistance Use One Single Angiographic View Measured After Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction Patients

Anticipated Study Start Date :

Dec 20, 2022

Anticipated Primary Completion Date :

Mar 20, 2023

Anticipated Study Completion Date :

Mar 20, 2024

Outcome Measures

Primary Outcome Measures

MACEs [12 months]
cardiac death, hospitalization for heart failure, target vessel revascularization，non-fatal MI

Secondary Outcome Measures

cardiac death [12 months]
Rates of individual components of MACE
hospitalization for heart failure [12 months]
Rates of individual components of MACE
target vessel revascularization [12 months]
Rates of individual components of MACE
non-fatal MI [12 months]
Rates of individual components of MACE

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Aged 18 or older
Type 1 myocardial infarction
Receive PPCI

Exclusion Criteria:

Failed to identify culprit vessels.
Structural heart disease with moderate to severe aortic valve or mitral regurgitation and or stenosis that may affect cardiac function
Dialysis patients with severe renal insufficiency
Severe and uncontrollable arrhythmia
Complicated with dilated cardiomyopathy
Unable to tolerate dual antiplatelet therapy
Severe and uncontrollable anemia
Hyperthyroidism
TIMI blood flow 0-1 grade after PPCI