Prognostic Value of Biomarkers in Polyneuropathy.
Study Details
Study Description
Brief Summary
Biomarkers for prognosis of patients with polyneuropathy.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
AIM: To investigate biomarkers' use as a prognostic tool in polyneuropathy patients.
STUDY DESIGN: Prospective cohort study of patients with polyneuropathy. METHODS: 200 patients with polyneuropathy will be examined with physical tests, medical examination, questionnaires, and blood biomarkers at baseline and at 1-year follow-up, and 2-year follow-up.
ANALYSIS: We will calculate the odds of disease progression after 2 years depending on biomarkers levels at baseline using multiple logistic regression with sex and age adjustment. Diagnostic performance of the physical tests and biomarkers for prediction of disease progression will be assessed by Receiver Operating Characteristic Curve analysis with the area under the curve.
Study Design
Outcome Measures
Primary Outcome Measures
- Disease Severity [2 years]
Primary outcome is disease severity
Secondary Outcome Measures
- PROM [2 years]
Secondary outcome is patient reported outcomes.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Minimum 18 years old.
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Diagnosed with polyneuropathy, confirmed by nerve conduction study.
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Can read and understand Danish.
Exclusion Criteria:
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Inability to perform physical tests due to comorbidity not associated to the patient's polyneuropathy.
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Polyneuropathy due to
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Rigshospitalet, Denmark
- Danish Cancer Society
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- H-23032146