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Prolactin Hormone in Oral Lichen Planus

Sponsor
October University for Modern Sciences and Arts (Other)
Overall Status
Completed
CT.gov ID
NCT04785703
Collaborator
Al-Azhar University (Other)
40
Enrollment
1
Location
5.7
Actual Duration (Months)
7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Oral lichen planus (OLP) is one of the most common mucosal diseases with autoimmune etio-pathogenesis with involvement of various cytokines similar to psoriasis.It generally occurs more commonly in females, in a ratio of 3:2. prolactin (PRL),It is a peptide hormone that has a role in autoimmune related diseases like systemic lupus erythematosus and , rheumatoid Artheritis. The role of PrL in OLP pathogenesis was never investigated.the aim of this study is to investigate the expression of PRL receptors in tissue biopsies of OLP patients.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    40 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Official Title:
    Prolactin Hormone in Oral Lichen Planus Tissue Samples
    Actual Study Start Date :
    Jun 19, 2020
    Actual Primary Completion Date :
    Aug 22, 2020
    Actual Study Completion Date :
    Dec 10, 2020

    Arms and Interventions

    Arm Intervention/Treatment
    oral lichen planus group

    patients with chronic bollus erosive lichen planus

    Outcome Measures

    Primary Outcome Measures

    1. prolactin receptors expression in oral mucous membrane [24 hours]

      immuno-histochemistry

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 60 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • patients with oral lichen planus

    • systemically healthy

    Exclusion Criteria:
    • oral lichenoid lesions

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 October University for modern sciences and arts Giza Egypt

    Sponsors and Collaborators

    • October University for Modern Sciences and Arts
    • Al-Azhar University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Naglaa Elwakeel, professor, October University for Modern Sciences and Arts
    ClinicalTrials.gov Identifier:
    NCT04785703
    Other Study ID Numbers:
    • REC18-048
    First Posted:
    Mar 8, 2021
    Last Update Posted:
    Mar 8, 2021
    Last Verified:
    Mar 1, 2021
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Lichen Planus, Oral
    Lichen Planus

    Study Results

    No Results Posted as of Mar 8, 2021