Prolonged Cardiopulmonary Bypass Time as a Predictive Factor for AGI After Heart Valve Replacement
Study Details
Study Description
Brief Summary
In this retrospective study, the investigators will analyze the correlation between cardiopulmonary bypass (CPB) time and acute gastrointestinal injury (AGI), and the outcomes of AGI in patients undergoing heart valve replacement.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Patients with heart valve diseases often have chronic cardiac insufficiency. Patients undergoing heart valve replacement with CPB are always complicated with gastrointestinal tract ischemia-reperfusion injury, which usually leads to AGI. AGI after cardiovascular surgery, especially in that use CPB, is associated with significant morbidity and an increase in peri-operative mortality. Prolonged CPB time could be predictive of AGI following heart valve replacement. This study is to analyze the correlation between CPB time and AGI, and the outcomes of AGI in patients undergoing heart valve replacement. The investigators hope that the benefits will include fewer patients becoming seriously postoperative AGI and mortality after cardiac surgery.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| CPB time ≥ 90 minutes No intervention, regular therapy |
Other: CPB time
Cardiopulmonary bypass time
|
| CPB time < 90 minutes No intervention, regular therapy |
Other: CPB time
Cardiopulmonary bypass time
|
Outcome Measures
Primary Outcome Measures
- Cardiopulmonary bypass (CPB) time [1 month]
Was defined it as the sum of times of CPB during surgery (minutes).
- The AGI score [1 month]
The AGI score of the patient within the seventh postoperative day was performed according to the European Society of critical care (2012) guidelines for AGI.
Secondary Outcome Measures
- Number of bowel sounds [1 month]
The return time of bowel sounds was evaluated morning and evening.
- First defecation time [1 month]
The time to the first defecation was asked morning and evening after surgery
- Proportion of cocci and bacilli in feces [1 month]
The first feces were collected in sterile containers for the bacterial smear
- Alanine aminotransferase (ALT) [1 month]
We defined it as the maximum value of ALT within 7 days after surgery.
- Aspartate aminotransferase (AST) [1 month]
We defined it as the maximum value of AST within 7 days after surgery
- Left ventricular ejection fraction (LVEF) [1 month]
We measured the LVEF on the 1st and 3rd days after operation by echocardiographic examinations
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients undergoing heart valve replacement surgery with CPB
-
Age > 18 years and ≤ 70 years
Exclusion Criteria:
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Patients combined with severe hematological disease, respiratory disease, and other critical diseases
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Patients had severe disorder of multiple systems and organs or severe pulmonary hypertension
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Have received major gastrointestinal surgery within 5 years
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Inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or colitis
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Acute gastroenteritis
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Clostridium difficile or Helicobacter pylori infection
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Chronic constipation
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Peptic ulcer
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Polyps in the stomach or intestines
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Gastrointestinal neoplasms
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Abdominal hernia
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Irritable bowel syndrome
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Acute or chronic cholecystitis, hepatitis
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Patients who died during surgery
-
Patients with digestive system tumors
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hepatopancreatobiliary Surgery Institute of Gansu Province | Lanzhou | Gansu | China | 730000 |
Sponsors and Collaborators
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Investigators
- Principal Investigator: Wenbo Meng, M.D. Ph.D, LanZhou University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CPB-AGI