Prospective Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery
Study Details
Study Description
Brief Summary
Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery: A Multicenter, Prospective, and Cohort Study
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
A clinical prediction model for VTE after neurosurgical procedures during hospitalization has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again.
Study Design
Outcome Measures
Primary Outcome Measures
- Symptomatic or asymptomatic VTE [2023.3-2023.7]
A combination of symptomatic or asymptomatic DVT and symptomatic or asymptomatic PE
Secondary Outcome Measures
- DVT [2023.3-2023.7]
A blood clot within a deep vein, typically in the thigh or leg, which is detected with compressible ultrasound, venography, impedence plethysmography, radiofibrinogen uptake scanning or autopsy based on the time of study. This outcome combines proximal or distal DVT of the leg, upper limb DVT
- PE [2023.3-2023.7]
Obstruction of a pulmonary artery or one of its branches that is usually produced by a blood clot which has originated in a vein of the leg or pelvis and traveled to the lungs, which is diagnosed by CT pulmonary angiography, ventilation-perfusion lung scanning pulmonary angiogram, or by autopsy or equivalent technology based on the time of study. This outcome combines saddle, lobar, segmental or subsegmental PE according to the anatomic location
- Proximal DVT [2023.3-2023.7]
Proximal DVT is a blood clot that is located in the popliteal, femoral, or iliac veins, which is detected with compressible ultrasound, venography, impedence plethysmography, radiofibrinogen uptake scanning or autopsy based on the time of study
Eligibility Criteria
Criteria
Inclusion Criteria:
-
age >18 years
-
underwent neurosurgical procedures during hospitalization
-
underwent preoperative ultrasound examination
Exclusion Criteria:
-
a patient with obvious bacterial or viral infection within the past two weeks before admission
-
a patient with venous thromboembolism within the past three months before surgery
-
a patient with anticoagulant therapy (direct oral anticoagulants, low molecular weight heparin) was administered continuously or intermittently before admission
-
a patient with a prior coagulation dysfunction
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Sanbo Brain Hospital, Capital Medical University | Beijing | China |
Sponsors and Collaborators
- Capital Medical University
Investigators
- Principal Investigator: Hongwei Zhang, Prof., Capital Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Val. VTE pred. model post-op