Effects of Prostate Cancer on Brain Function
Study Details
Study Description
Brief Summary
To explore whether the patients with prostate cancer have functional changes in specific brain areas and changes in psychological and mental characteristics compared with the patients without prostate cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
This study was intended to observe the functional changes of brain fMRI in patients with and without prostate cancer enrolled in the cohort of patients who planned to undergo prostate biopsy, in an attempt to discover specific brain region changes in patients with prostate cancer, and lay a foundation for further clarifying the relationship and mechanism between brain region function changes and prostate cancer.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Prostate cancer group Prostate cancer was confirmed by biopsy, and fMRI examination and functional assessment of cancer therapy-prostate（FACT--P） questionnaire evaluation were performed in these patients within 1 week before biopsy and at 1, 3 months after biopsy. |
Diagnostic Test: functional magnetic resonance imaging examination and functional assessment of cancer therapy-prostate（FACT--P） questionnaire
fMRI examination and functional assessment of cancer therapy-prostate（FACT--P） questionnaire were performed in these patients within 1 week before biopsy and at 1, 3 months after biopsy.
|
| Non-Prostate cancer group Non-Prostate cancer was confirmed by biopsy, and fMRI examination and functional assessment of cancer therapy-prostate（FACT--P）questionnaire evaluation were performed in these patients within 1 week before biopsy and at 1, 3 months after biopsy. |
Diagnostic Test: functional magnetic resonance imaging examination and functional assessment of cancer therapy-prostate（FACT--P） questionnaire
fMRI examination and functional assessment of cancer therapy-prostate（FACT--P） questionnaire were performed in these patients within 1 week before biopsy and at 1, 3 months after biopsy.
|
Outcome Measures
Primary Outcome Measures
- The evaluation of Magnetic Resonance(MR) [Within 1 week before biopsy and at 1, 3months after biopsy]
To compare the differences in rs-fMRI measures (Amplitude of low frequency fluctuations , Regional Homogeneity and Functional Connectivity ) between prostate cancer group and Non-prostate cancer group.
Secondary Outcome Measures
- Assessment of anxiety status [Within 1 week before biopsy and at 1, 3months after biopsy]
Zung Self Rating Anxiety Scale was used to assess anxiety status.
- Assessment of depressive status [Within 1 week before biopsy and at 1, 3months after biopsy]
Beck Depression Inventory-II was used to assess depressive status.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Between the ages of 18 and 80
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Patients with prostate biopsy;
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No history of other malignant tumors;
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Exclude other malignant tumors;
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Fully understand the clinical trial protocol and sign informed consent;
Exclusion Criteria:
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magnetic resonance contraindications;
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symptomatic acute or chronic inflammation of the prostate;
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Patients with brain trauma or brain disease;
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Patients who have died of other malignancies in the past or are currently suffering from other malignancies;
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Patients judged by the investigator to be unfit to participate in the clinical trial;
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Shanghai East Hospital, Tongji University School of Medicine | Shanghai | Shanghai | China | 200120 |
Sponsors and Collaborators
- Shanghai East Hospital
Investigators
- Principal Investigator: Haifeng Wang, Shanghai East Hospital,Tongji University School of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- EF2023-01