Effects of High-intensity Training Compared to Resistance Training in Cancer Patients Undergoing Radiotherapy
Study Details
Study Description
Brief Summary
The aim of this study is to assess the impact of a high-intensity aerobic training and resistance training on fatigue in prostate, head and neck and rectum cancer patients undergoing radiotherapy.
A three-arm randomized controlled trial will be conducted. Patients will be randomised into either a high-intensity aerobic training group or a resistance training group or a control group. Participants in the training groups will exercised for five to eight weeks. Exercise sessions will be take place 3 days per week under the supervision of an experienced therapist. Subjects will be assessed at baseline and post-intervention. The primary outcome will be fatigue measured using the FACIT-fatigue questionnaire. The secondary outcomes will be: functional capacity, quality of life, executive functions, sleep disturbances, somnolence syndrome, insomnia, depression symptoms.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: High-intensity aerobic training group High intensity interval training |
Behavioral: High-intensity interval training
High-intensity interval training sessions will be conducted on cycle ergometers or treadmill with heart rate measured throughout each session.
|
| Active Comparator: Resistance training group Muscle strengthening |
Behavioral: Resistance training
Resistance exercise will be performed on eight exercises targeting major muscle groups at 60% to 85% of their estimated one-repetition maximum (1RM).
|
| No Intervention: Control group Usual care |
Outcome Measures
Primary Outcome Measures
- Change in fatigue [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Fatigue is measured by FACIT-fatigue questionnaire
Secondary Outcome Measures
- Change in functional capacity [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Functional capacity is measured by 6-minute walk test
- Change in quality of life [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Quality of life is measured by Functional Assessment of Cancer Therapy-General
- Change in sleep disturbances [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Sleep disturbances are measured by Pittsburgh Sleep Quality Index
- Change in somnolence syndrome [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Somnolence syndrome is measured by Epworth Sleepiness Scale
- Change in insomnia [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Insomnia is measured by Insomnia Severity Index
- Change in depression symptoms [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Depression symptoms are measured by Center for Epidemiologic Studies Depression Scale
- Change in executive functions [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Executive functions is measured by the Trail Making Test
- Change in dyspnea [Assessments at baseline and 5 weeks (rectum cancer) or 7 weeks (head and neck cancer) or 8 weeks (prostate cancer)]
Dyspnea is measured by Multidimensional Dyspnea Profile
- Adherence [Weekly through the intervention (during 8 weeks)]
Percentage of completed sessions
Eligibility Criteria
Criteria
Inclusion criteria :
-
a primary diagnosis of prostate cancer, head and neck cancer (oral cavity, pharynx, larynx, nasal cavity/sinuses, or salivary gland) or rectum cancer;
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age over 18 years;
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no distant metastases and/or disease progression;
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at least 25 scheduled radiation treatments (5 weeks);
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ability to read, write, and speak French.
Exclusion criteria :
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uncontrolled cardiac, hypertensive or pulmonary diseases,
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uncontrolled insulin-dependent diabetes mellitus,
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neuropsychiatric disorders or orthopaedic conditions that would impair exercise participation
-
abnormal electrocardiogram.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Cliniques universitaires Saint-Luc | Brussels | Belgium | 1200 |
Sponsors and Collaborators
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 1