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Prostate Cancer Risk in Firefighters

Sponsor
Oslo University Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT03893123
Collaborator
Cancer Registry of Norway (Other), Extrastiftelsen (Other), National Institute of Occupational Health (Other), Norwegian Confederation of Trade Unions (Other), Fagforbundet (Other), Gjensidige Foundation (Other), Norwegian Cancer Society (Other), Norwegian Firefighters Fight Cancer (Other), Norwegian Labour Inspection Authority (Other)
4,500
Enrollment
1
Location
47
Anticipated Duration (Months)
95.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Firefighters have been shown to be at increased risk for various types of cancer, including prostate cancer. This study will try to explore possible reasons for this increase in risk. A study group at the Cancer Registry of Norway is creating a cohort of Norwegian firemen employed from 1960 onwards. A job exposure matrix (JEM) is also being constructed, examining different types of exposure to potentially cancer-inducing agents and activities, and how these have changed historically. Examples include exposure to fire-smoke, shiftwork, diesel exhaust and regular health check-ups. By linking the cohort with data from the Cancer Registry of Norway and the JEM the investigators can examine which exposure assessments, if any, are related to an increased risk of prostate cancer.

Condition or Disease Intervention/Treatment Phase
  • Other: Observational study, prostate cancer is outcome of interest

Study Design

Study Type:
Observational
Actual Enrollment :
4500 participants
Observational Model:
Cohort
Time Perspective:
Retrospective
Official Title:
Prostate Cancer Risk in Firefighters: Its Association to Qualitative and Quantitative Indicators of Exposure
Actual Study Start Date :
Jan 1, 2018
Actual Primary Completion Date :
Feb 1, 2020
Anticipated Study Completion Date :
Dec 1, 2021

Arms and Interventions

Arm Intervention/Treatment
Firefighters

Other: Observational study, prostate cancer is outcome of interest
Observational study

Outcome Measures

Primary Outcome Measures

  1. Incidence of prostate cancer [From January 1st 1960 until December 31st 2018]

    As reported to the Cancer Registry of Norway

Eligibility Criteria

Criteria

Ages Eligible for Study:
N/A and Older
Sexes Eligible for Study:
Male
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Work as firefighter as recorded by the participating fire stations
Exclusion Criteria:
  • Any other occupation, including chimney sweepers

Contacts and Locations

Locations

Site City State Country Postal Code
1 Cancer Registry of Norway Oslo Norway 0304

Sponsors and Collaborators

  • Oslo University Hospital
  • Cancer Registry of Norway
  • Extrastiftelsen
  • National Institute of Occupational Health
  • Norwegian Confederation of Trade Unions
  • Fagforbundet
  • Gjensidige Foundation
  • Norwegian Cancer Society
  • Norwegian Firefighters Fight Cancer
  • Norwegian Labour Inspection Authority

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Jarle Jakobsen, PhD-student, Cancer Registry of Norway
ClinicalTrials.gov Identifier:
NCT03893123
Other Study ID Numbers:
  • 2016/2282
First Posted:
Mar 28, 2019
Last Update Posted:
Mar 4, 2020
Last Verified:
Mar 1, 2020
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Prostatic Neoplasms

Study Results

No Results Posted as of Mar 4, 2020