Protection Against Benzene Toxicity

Sponsor

National Institute of Environmental Health Sciences (NIEHS) (NIH)

Overall Status

Completed

CT.gov ID

NCT00011453

Collaborator

(none)

Location

Duration (Months)

Study Details

Study Description

Brief Summary

We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.

Condition or Disease	Intervention/Treatment	Phase
Leukemia Aplastic Anemia

Study Design

Study Type:

Observational

Time Perspective:

Prospective

Official Title:

NQO1 in Protection Against Benzene Toxicity

Study Start Date :

Jul 1, 1998

Study Completion Date :

Jun 1, 2001

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

21 Years to 65 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Colorado Health Sciences Center	Denver	Colorado	United States	80262

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

, ,

ClinicalTrials.gov Identifier:

NCT00011453

Other Study ID Numbers:

9554-CP-001

First Posted:

Feb 23, 2001

Last Update Posted:

Jun 24, 2005

Last Verified:

Jul 1, 2002

Keywords provided by , ,

Additional relevant MeSH terms:

Anemia, Aplastic

Study Results

No Results Posted as of Jun 24, 2005