Clincosm LogoSign in Get a demo

Proteomics in Multiple Trauma to Identify Organ Failure

Sponsor
Universitätsklinikum Köln (Other)
Overall Status
Recruiting
CT.gov ID
NCT02030327
Collaborator
(none)
85
Enrollment
1
Location
107
Duration (Months)
0.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

To analyse differences in protein expression in multiple trauma patients for identification of potential biomarkers to predict organ dysfunction.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The aim of the present study in humans is to analyse differences in protein expression after multiple trauma in patients for identification of potential biomarkers to predict organ dysfunction.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    85 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Analysis of Predictive Parameters by Proteomics for Early Diagnosis of Organ Dysfunction in Multiple Trauma Patients - A Pilot Study
    Study Start Date :
    Jan 1, 2014
    Anticipated Primary Completion Date :
    Dec 1, 2022
    Anticipated Study Completion Date :
    Dec 1, 2022

    Arms and Interventions

    Arm Intervention/Treatment
    No trauma

    n=5 patients
    trauma without organ dysfunction

    n=40 patients
    trauma with organ dysfunction

    n=40 patients

    Outcome Measures

    Primary Outcome Measures

    1. Number of patients with disease or death vs. healthy [Day 0 until day 20]

      Starting at day O, then every 24 hours until day 20

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • older than 18 years

    • multiple trauma patients

    • ISS >16

    Exclusion Criteria:

    • children

    • ISS <16

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University Hospital of Cologne Cologne NRW Germany 50937

    Sponsors and Collaborators

    • Universitätsklinikum Köln

    Investigators

    • Principal Investigator: Jochen Hinkelbein, MD, UK Köln

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Jochen Hinkelbein, Priv.-Doz. Dr. med., Universitätsklinikum Köln
    ClinicalTrials.gov Identifier:
    NCT02030327
    Other Study ID Numbers:
    • 12-236
    First Posted:
    Jan 8, 2014
    Last Update Posted:
    May 17, 2022
    Last Verified:
    May 1, 2022
    Keywords provided by Jochen Hinkelbein, Priv.-Doz. Dr. med., Universitätsklinikum Köln
    proteomics
    multiple trauma
    organ dysfunction
    Additional relevant MeSH terms:
    Wounds and Injuries
    Multiple Trauma

    Study Results

    No Results Posted as of May 17, 2022