Ultraviolet Radiation Forecasting Based Heliotherapy For Psoriasis in Bangkok, Thailand

Sponsor

Chulalongkorn University (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT04740983

Collaborator

King Chulalongkorn Memorial Hospital (Other)

Enrollment

Arms

9.6

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Due to limited number of phototherapy centres and shortage of qualified phototherapy practitioners, heliotherapy has become a promising treatment alternative in Thailand where patients effortlessly receive supervised sun-bathing treatments from their homes whenever they are convenient. We used newly designed deep neural network UV forecasting model developed by using our 10 year-retrospective Solar UV irradiance (280-400 nm) retrieved from a ground based platform at Atmosperic laboratory, Silpakorn University, Nakhon Pathom, Thailand (13.82N 100.04E, 30 m above mean sea level). This model achieved a next-day forecast error of less than 12% which has been the most accurate prediction to date. We designed our 10week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values. We studied efficacy and safety of the 12-week heliotherapy regimen for psoriasis on only ruled acceptable clear sky days in Bangkok, Thailand

Condition or Disease	Intervention/Treatment	Phase
Psoriasis Vulgaris	Other: Heliotherapy (a sole sun-bathing)	N/A

Detailed Description

We studied efficacy and safety of the 16-week heliotherapy regimen for psoriasis on only ruled acceptable clear sky days in Bangkok, Thailand

Study Design

Study Type:

Interventional

Anticipated Enrollment :

20 participants

Allocation:

Randomized

Intervention Model:

Single Group Assignment

Masking:

Double (Investigator, Outcomes Assessor)

Primary Purpose:

Treatment

Official Title:

The Study of Efficacy and Safety of UV Forecasting Based Heliotherapy For Psoriasis in Bangkok, Thailand: A Split-side Pilot Study

Anticipated Study Start Date :

Mar 15, 2021

Anticipated Primary Completion Date :

Aug 30, 2021

Anticipated Study Completion Date :

Dec 31, 2021

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Heliotherapy will receive 16-week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values along with olive oil (in-house formulation)	Other: Heliotherapy (a sole sun-bathing) 16-week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values.
No Intervention: Control only will receive olive oil (in-house formulation)

Arm

Intervention/Treatment

Experimental: Heliotherapy

will receive 16-week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values along with olive oil (in-house formulation)

Other: Heliotherapy (a sole sun-bathing)

16-week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values.

No Intervention: Control

only will receive olive oil (in-house formulation)

Outcome Measures

Primary Outcome Measures

Changes of Targeted PASI score [16 weeks]
PASI score for targeted plagues will be evaluated by two independent dermatologists (EB, PA) from standard digital photographs.

Secondary Outcome Measures

Incidence of possible acute side effects after sun bathing [16 weeks]
Potential acute effects of the exposure of full-spectrum solar radiation

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

A psoriasis patient who indicate to have phototherapy and have lesional plagues systemically either on the front-back or left-right.
A participant is based in Bangkok
A participant is capable to understand and learn how to use our in-house assembled UV metre and web-based heliotherapy platform.

Exclusion Criteria:

A participant has any sun-sensitive conditions including photo-aggravated photodermatoses and on photosentisitive drug treatments.
Breast-feeding, pregnant individuals.