Psychiatric Orders in Psychoanalytic Treatment of ASD
Study Details
Study Description
Brief Summary
Autism Spectrum Disorder (ASD) is often accompanied by a variety of other symptoms, such as bipolar disorder, Attention Deficit Hyperactivity Disorder (ADHD), Social Anxiety Disorder (SAD), Avoidant Personality Disorder (AvPD), Obsessive Compulsive Disorder (OCD), etc. The behavioral and social complications often marginalize the population, impact on life satisfaction, undermined societal values that impact on economic and financial fairness, and so forth. Furthermore, persons with ASD are neurodiverse from standardized pharmacological and clinical cares, and are interpreted disadvantaged in the context of neurotypical treatments.
The research protocol aims to differentiate the neuropharmacological implications of ASD from its behavioral and social implications. Such a differentiation is beneficial to the quality of care for neurodiverse population, both in terms of precision treatment in medical settings, and in terms of psychotherapeutic treatment efficacy in the interpretation of behavioral and social traits.
The study protocol continues from the adverse event of the participant in NCT05711810 trial, after the positive immunological results in the NCT05839236 trial. The intervention medicine continues from Sertraline adjusted on the choice of Selective Serotonin Reuptake Inhibitor (SSRI) in the previous two trials for complex post-traumatic stress disorder (CPTSD) of the participant, and its combined used with Duloxetine in the choice of Selective Norephedrine Reuptake Inhibitor (SNRI) for norephedrine regulations.
The hypothesized target is on the discrete psychiatric intervention centered approach to ASD treatment care. In the PRC where the study is being carried out, amphetamine class medicines are strictly prohibited and defined as illegal substances, regardless of their only proven effect for ASD patient care. Contributed by the sociostructural elements and necessities, black market amphetamine and ketamine have not only emerged in the regime for decades, but also have become a lucrative business. Their recreational uses are also sometimes accompanied by real necessities and needs; black markets cater to the needs but guidance on the usages is based on word-of-mouth stories without professional medical assistances. There is one case the Principal Investigator (PI) collected, that one person, possibly under depression contributed by PTSD, took relatively high dosage of amphetamine and went into a state of psychosis with overwhelming persecution mania. The study protocol, Psychiatric Orders in Psychoanalytic Treatment of ASD, is therefore designed for an evidence-based approach in treating complex psychiatric disorders with psychoanalytic guidance.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Participant Case The participant started taking SNRI duloxetine 20 mg/night in Jan. 2023, and changed to SSRI sertraline 50 mg/d in Mar. 2023. The apparent positive psychedelic effects did not take effect until increased dosage to sertraline 100mg/d after around one week in Jun. 2023. Duloxetine is planned to be added to the mix thereon. |
Diagnostic Test: Psychoanalysis
Case-specific psychoanalysis is performed, including the participant's background during birth.
Other Names:
Drug: sertraline 50mg
After the initial assessment of 50 mg/d, the treatment dosage is determined at 100 mg/d.
Other Names:
Drug: Duloxetine 20 MG
Duloxetine is used with 20 mg/night for subsidiary effects with sertraline.
Other Names:
Behavioral: Cognitive Behavioral Therapy
CBT is tailored to the participant's current activities and life decisions.
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Outcome Measures
Primary Outcome Measures
- Hamilton Anxiety Rating Scale (HAM-A) [90 days]
- Generalized Anxiety Disorder (GAD-7) [90 days]
- Dissociative Experiences Scale - II (DES-II) [90 days]
- The Defeat Scale (D Scale) [90 days]
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS) [90 days]
- Severity Measure for Agoraphobia-Adult [90 days]
- BPD Check List [90 days]
- Rosenberg Self-Esteem Scale (RSE) [90 days]
- Young Schema Questionnaire (YSQ) [90 days]
- Personality Belief Questionnaire (PBQ) [90 days]
- Behavioral Satisfaction Questionnaire (X axis) [90 days]
The X axis score total range -150 to +140, from self-centrism (passive-aggressiveness) to proactive social behaviors.
- Behavioral Satisfaction Questionnaire (Y axis) [90 days]
The Y axis score total range -200 to +195, from inhibition to excitation of the hypothalamic-pituitary-adrenal (HPA) axis in daily lives.
Secondary Outcome Measures
- Heart Rate [90 days]
Heart rate is used to correlate to the participant's mode change.
- Systolic Blood Pressure [90 days]
Systolic blood pressure is measured for reference on psychoneurotic correlations.
- Diastolic Blood Pressure [90 days]
Diastolic blood pressure is measured for reference on possible side-effects with dizziness etc.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Persons with ASD.
Exclusion Criteria:
- Severe ASD cases with central nerve system complications.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Residential Address | Chongqing | Chongqing | China | 402762 |
Sponsors and Collaborators
- Yang I. Pachankis, PhD
- S for Science
Investigators
None specified.Study Documents (Full-Text)
More Information
Publications
- Pachankis Y. Jeopardies in human security and politicization of COVID-19. Ethics Med Public Health. 2023 Apr;27:100871. doi: 10.1016/j.jemep.2023.100871. Epub 2023 Feb 1. No abstract available.
- Yang IP. A Self--help Guide to Psychoanalysis in Cisgender Homosexual Male. Journal of Marketing Management and Consumer Behavior. 2022; 4(2), 93-110.
- Yang IP. An Evidence-driven Research to the Transgressions of Geneva Conventions by the Communist Party of China Led Autocratic Regime. International Journal of Scientific & Engineering Research. 2022; 13(10): 249-266.
- Yang IP. Correlating Nuclear Sciences to Biochemistry - Mini-review on the Environmental Physiological Impact of Electronic Warfare on Public Health. Journal of Clinical Chemistry. 2022; 1(2): 1-5.
- Yang IP. Dictatorial Psychopathological Commination in Server-Side Public Mental & Psychological Menace. Biomedical Science and Clinical Research. 2023; 2(2): 173-184.
- Yang IP. Mass Surveillance, Behavioural Control, and Psychological Coercion - The Moral Ethical Risks in Commercial Devices. In: Wyld, D. C. & Nagamalai, D. (Eds.) Computer Science and Information Technology. 2022; 151-168. AIRCC Publishing Corporation.
- Yang IP. Proton Decay Reconstruction in Conscious Phenomenon - Literature Review on MRI, EEG, and PET Technologies. Advances in Sexual & Reproductive Health Research. 2022; 1(1): 128-130.
- Yang IP. Proton Paths of Cardiac Immune Reflex. Online Journal of Cardiology Research & Reports. 2023; 7(1): 000655.
- Yang IP. Questions of COVID-19: Institutional Derogations of Global Health. Lambert Academic Publishing. 2023. ISBN: 978-6206153849.
- Yang IP. Targeted Human Trafficking - The Wars between Proxy and Surrogated Economy. International Journal of Scientific & Engineering Research. 2022; 13(7): 398-409.
- Yang IP. Technical Analysis on the Cyber Organizational Criminology of Dictatorial Military Conducts -- Experience from Human Trafficking and Coercions by Military Cyber Aggressions. International Journal of Security, Privacy and Trust Management. 2022; 11(3): 1-19.
- Yang IP. The Cultural Revisionist Element behind P. R. China's Neo-Nazism: A Cross-cultural and Cross-religion Research. International Journal of Advanced Multidisciplinary Research and Studies. 2022; 2(4): 435-451.
- Yang IP. What Do We Need in Adolescence?. Journal of Addiction Research. 2023; 7(1): 7-8.
- Yang IP. Why Should LGBTQI Marriage Be Legalized. Academia Letters. 2022; Article 5157.
- ASD-Psy-000
- ASD-000000