SOURIPSY: Source-monitoring & Psychosis
Study Details
Study Description
Brief Summary
Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at ultra-high risk for psychosis (UHR) and in first-episode psychosis patients (FEP). Source-monitoring deficits have thus been proposed as a potential early risk factor for psychosis. However, further studies are needed to better characterize this deficit.
The aim of this project is to investigate source-monitoring performances in UHR, FEP patients and healthy controls (HC) and to characterize these deficits in terms of brain anatomy, basic auditory processes and social functioning.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
Ninety participants will be included in the study: 30 UHR, 30 FEP and 30 healthy controls. All the participants will complete a standardized source-monitoring task, an MRI acquisition (3D-T1 anatomical scan), a tone-matching task as well as a socio-demographic and clinical evaluation including an assessment of the social functioning.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: individuals at ultra-high risk for psychosis (UHR) 30 individuals meeting the UHR criteria according to the "Comprehensive Assessment of at-risk mental state" (CAARMS) will be recruited and will complete cognitive task and MRI scan |
Other: Cognitive tests and neuroimaging
comparison of cognitive performances and brain anatomy
|
Experimental: patients with first episode psychosis (FEP) 30 patients with first episode psychosis (FEP) will be recruited and will complete cognitive task and MRI scan |
Other: Cognitive tests and neuroimaging
comparison of cognitive performances and brain anatomy
|
Sham Comparator: healthy controls 30 healthy individuals will be recruited and will complete cognitive task and MRI scan |
Other: Cognitive tests and neuroimaging
comparison of cognitive performances and brain anatomy
|
Outcome Measures
Primary Outcome Measures
- Source-monitoring performances [one day]
Scores obtained at a source-monitoring task (Brunelin et al., 2006)
Secondary Outcome Measures
- Confidence in source-monitoring judgements [one day]
Confidence in source-monitoring judgements will be measured using a visual analogue scale (0-100)
- Grey matter volume [one day]
Grey matter volume will be assessed with a structural MRI scan (3D-T1) followed by morphometry analyses.
- Brain gyrification [one day]
Brain gyrification will be assessed with a structural MRI scan (3D-T1) followed by gyrification analyses.
- Basic auditory performances [one day]
scores at the Tone Matching Task (Strous et al., 1995)
- Working memory performances [one day]
scores at a working memory task (Barrouillet et al., 2004)
- Social functioning [one day]
score at the "personal and social performance scale" (0-100)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Men and Women aged between 18 and 30
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Having given their written informed consent
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French speakers and readers
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Absence of hearing impairments (or tinnitus) that could prevent the successful completion of tasks involving listening to sounds or words
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Absence of visual impairments that could prevent the successful completion of tasks involving reading on the screen
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For the healthy control group, no history of previous diagnosed psychiatric disorders (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM5), absence of relatives diagnosed with spectrum disorder schizophrenia and bipolar disorder (DSM5), absence of psychotic prodromes measured by a score of less than 6 in the "prodromal questionnaire" - PQ-16 (Ising et al., 2012), absence of drug treatments (except oral contraception).
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For the UHR group, meeting the UHR criteria according to the "Comprehensive Assessment of at-risk mental state" (CAARMS).
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For the FEP group, presenting with daily psychotic symptoms for at least a week.
Exclusion Criteria:
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Do not consent to be included in the study
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Contraindication to MRI scan
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History of neurological disease
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Pregnancy
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Being under tutorship or curatorship
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Having developed musical abilities (that is, regularly practicing a musical instrument)
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Centre Hospitalier le Vinatier | Bron | France | 69678 | |
2 | Centre Hospitalier le Vinatier | Bron | France | 69678 |
Sponsors and Collaborators
- Hôpital le Vinatier
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2019-A02499-48