Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence

Sponsor

Medical University of South Carolina (Other)

Overall Status

Completed

CT.gov ID

NCT00330239

Collaborator

GlaxoSmithKline (Industry)

Enrollment

Location

Duration (Months)

0.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Pharmacotherapy has demonstrated efficacy in a number of controlled trials in the treatment of PTSD. The selective serotonin reuptake inhibitors have proven particularly useful in treating this disorder. Currently there are two selective serotonin reuptake inhibitors (Zoloft® and Paxil®), that have been FDA approved for treating PTSD. Coincidentally, this same class of medications has also been shown to have efficacy in some trials in decreasing alcohol consumption in heavy drinkers. The goal of the proposed study is to preliminarily investigate the efficacy of Paxil® (paroxetine), in decreasing symptoms of PTSD as well as decreasing substance use, in individuals with concurrent substance dependence and PTSD. The type of paroxetine used in this trial will be Paxil CR®, which is a sustained release formulation of paroxetine, which has fewer side effects and greater tolerability. This is a particularly important issue in substance using populations because medication compliance is generally poor.

Two specific hypotheses will be tested. 1) Individuals who receive Paxil CR® will have a greater improvement in their PTSD symptoms (based on CAPS-2 and CGI) than those who receive placebo. 2) Individuals who receive Paxil CR® will have greater improvement in their substance use outcomes (based on UDS and TLFB) than will those who receive placebo.

Condition or Disease	Intervention/Treatment	Phase
PTSD	Drug: Paroxetine CR	Phase 4

Detailed Description

Participants who meet all inclusion and no exclusion criteria will be randomized with a 1:1 ratio to receive either Paxil CR or placebo for 12 weeks. Medication will be initiated at 12.5mg/day and will be increased weekly as tolerated to a maximum dose of 50mg/day. Participants will be seen weekly and will be assessed for side effects, substance use since last visit, urine drug screen, breathalyzer readings, vital signs and symptoms of PTSD (TOP-8)at each visit. The Davidson Trauma Scale will be completed every two weeks, and the CAPS-2 and MADRS will be completed monthly. Those who complete the first 12 weeks of double-blind study medication will be eligible to receive open label medication for an additional 12 weeks. Medication will be initiated at 12.5mg and increased every 3 days as tolerated to the terminal dose in the double-blind phase, then adjusted as needed. Participants will come in for assessments every two weeks of the open-label phase. Blood will be drawn for blood chemistries and hematology at screening and weeks 12 and 24. Urine pregnancy tests will be performed for women of childbearing potential at baseline and again at weeks 4, 12 and 24.

Study Design

Study Type:

Interventional

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Double

Primary Purpose:

Treatment

Official Title:

Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence

Study Start Date :

Jan 1, 2003

Study Completion Date :

May 1, 2005

Outcome Measures

Primary Outcome Measures

Clinician Administered PTSD Scale (CAPS) []
Clinical Global Impressions Scale []

Secondary Outcome Measures

Davidson Trauma Scale []
Time-Line Follow-Back []

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 65 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Men and women aged 18 to 65
Outpatients who meet DSM-IV criteria for PTSD, chronic subtype, based on CAPS-1
Must have a minimum score of 50 on the CAPS-2 at Baseline
Must meet DSM-IV criteria for a substance dependence disorder in the last 3 months (excluding caffeine and nicotine)
Must be able to read English
Must give written informed consent

Exclusion Criteria:

Individuals with a primary psychiatric disorder other than PTSD
Individuals with an uncontrolled neurologic condition that could confound the results of the study (e.g. seizure disorder)
Individuals with an uncontrolled medical condition that may adversely affect the conduct of this trial or jeopardize subject safety
Concomitant use of other psychotropic medications (intermittent use of diphenhydramine and zolpidem will be allowed during the study) see concommitant meds on page 5 of the protocol
Women of childbearing potential who are pregnant, lactating or refuse to use adequate forms of birth control
Individuals who have failed an adequate trial of paroxetine in the past
Current suicidal or homicidal risk
Currently receiving trauma-specific psychotherapy
Individuals taking any herbal psychoactive treatments (e.g. St. John's Wart)
Individuals engaged in compensation litigation whereby personal gain would be achieved from prolonged symptoms of PTSD or any other psychiatric disorder
Individuals, who in the investigator's opinion would be unable to comply with study procedures or assessments

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Medical University of South Carolina	Charleston	South Carolina	United States	29464

Sponsors and Collaborators

Medical University of South Carolina
GlaxoSmithKline

Investigators

Principal Investigator: Susan C Sonne, PharmD, Medical University of South Carolina
Principal Investigator: Kathleen T Brady, MD, PhD, Medical University of South Carolina