Pulmonary Physiologic Assessment of Patients on Veno-arterial Extracorporeal Membrane Oxygenation (VA ECMO)
Study Details
Study Description
Brief Summary
There is limited data on the respiratory system mechanics and ideal mode of ventilation for patients on veno-arterial extra-corporeal membrane oxygenation (VA ECMO) post cardiac arrest. In this observational study, the investigators will review and/or obtain laboratory, hemodynamic, respiratory system mechanical, and clinical data from patients on VA ECMO. The specific aims of this study are as follows:
Aim 1: To characterize the lung ventilation strategy employed in patients on VA ECMO and its success.
Aim 2: To characterize respiratory system mechanics while on ECMO using esophageal manometry and Electrical Impedance Tomography (EIT).
Aim 3: To characterize right heart function and pulmonary vascular hemodynamics on the employed ventilation strategy.
The overarching hypothesis is that fine-tuned individualized ventilation might be superior to an algorithm that does not account for cardiac and pulmonary functions. Therefore, the aims of this study are to identify areas in which the ventilation strategy may theoretically be suboptimal, which will guide future interventional studies investigating alternatives methods of ventilation which may reduce time on the ventilator after cardiac arrest, time in the intensive care unit, and need for VV ECMO.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- Percent of total distribution of ventilation by region, on given ventilator settings [Within 24-48 hours of ECMO cannulation]
EIT will be used to determine the percent of total ventilation occurring in each of four lung quadrants on an axial plane: right upper, left upper, right lower, and left lower.
Secondary Outcome Measures
- Time on VA-ECMO [14 days, 90 days]
- Need to transition to VV-ECMO [14 days, 90 days]
- Time on mechanical ventilation [14 days, 90 days]
- Time in ICU [14 days, 90 days]
- 90-day mortality [90 days]
- Incidence of ventilator-associated pneumonia [14 days, 90 days]
Eligibility Criteria
Criteria
Inclusion Criteria:
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On VA ECMO after cardiac arrest
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Between 18 and 85 years of age
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Has an orogastric or nasogastric tube with esophageal balloon capabilities in place
Exclusion Criteria:
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Known pre-existing significant pulmonary pathology
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Pacemaker or implanted cardiac defibrillator
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Massachusetts General Hospital | Boston | Massachusetts | United States | 02135 |
Sponsors and Collaborators
- Massachusetts General Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2020P003054