Pulmonaryhypertension in Copd at Different Levels of Smoking

• Sponsor: Assiut University (Other)
• Overall Status: Not yet recruiting
• CT.gov ID: NCT06031311
• Collaborator: (none)
• Enrollment: 138
• Anticipated Duration (Months): 14

Study Details

Study Description

Brief Summary

To identify Predictors of pulmonary hypertension in COPD patients and its relation to different levels of smoking

Condition or Disease	Intervention/Treatment	Phase
Pulmonary Hypertension	Diagnostic Test: Echocardiography and HRCT

Detailed Description

COPD is a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, expectoration and/or exacerbations) due to abnormalities of the airways (bronchitis, bronchiolitis) and/or alveoli (emphysema) that cause persistent, often progressive, airflow obstruction.It is also the most common cause of deaths in patients with chronic respiratory disease, the fatality rate in USA is 0.41%.Pulmonary Hypertension is the most common serious complication in COPD patients ; which occurs in up to 30% of patients and increases the mortality rate.Smoking is the leading cause of chronic obstructive pulmonary disease (COPD) Smoking is also a trigger for COPD flare-ups.Smoking damages the air sacs, airways, and the lining of your lungs. Injured lungs have trouble moving enough air in and out, so it's hard to breathe

Study Design

• Study Type: Observational
• Anticipated Enrollment: 138 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Clinical Characteristics and Predictors of Pulmonary Hypertension in COPD at Different Levels of Smoking
• Anticipated Study Start Date: Oct 1, 2023
• Anticipated Primary Completion Date: Oct 1, 2024
• Anticipated Study Completion Date: Dec 1, 2024

Outcome Measures

Primary Outcome Measures

1. Predictors of pulmonary hypertension in COPD patients [1 year]

   Predict pulmonary hypertension in COPD patients

Secondary Outcome Measures

1. Relationship between different levels of smoking and predictors of degree of pulmonary hypertension [1 year]

   Levels of smoking (mild.moderate.sever.non smoker) and it's relation to pulmonary hypertension in COPD patients

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 100 Years
• Sexes Eligible for Study: All

Inclusion Criteria:

• 1.All patients admitted to chest department or presented to our outpatient clinic with clinical and functional diagnosis of COPD among both sexes will be included 2.Age >18 years Old

Exclusion Criteria:

• 1.Patients under 18 years old. 2.pregnant patients. 3.patients with history hypertension or valvular diseases 4.Cardiomyopathic patient 5.Patients with concomitant obstructive sleep apnea 6.Patients with collagen vascular disease 7.Patients with thrombo-embolic disease 8. Patients with any chronic chest disease other than COPD

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• Assiut University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

• Global Initiative for Chronic Obstructive Lung Disease 2023

Publications

None provided.

• Responsible Party: Shrouk Mohamed Salah Mosleh, Resident doctor, Assiut University
• ClinicalTrials.gov Identifier: NCT06031311
• Other Study ID Numbers: Pulmonaryhypertension in copd
• First Posted: Sep 11, 2023
• Last Update Posted: Sep 14, 2023
• Last Verified: Sep 1, 2023

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Hypertension, Pulmonary; Hypertension

Study Results

No Results Posted as of Sep 14, 2023