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Pyrosequencing of the BRAFV600E Mutation

Sponsor
Chungnam National University (Other)
Overall Status
Completed
CT.gov ID
NCT00551486
Collaborator
(none)
101
Enrollment
1
Location
6
Duration (Months)
16.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

To investigate the diagnostic efficiency of pyrosequencing for the mutant BRAF allele in ultrasound (US)-guided fine needle aspiration biopsies (FNAB) of thyroid incidentalomas.

Condition or Disease Intervention/Treatment Phase
  • Procedure: ultrasound-guided fine needle aspiration biopsy

Study Design

Study Type:
Observational
Actual Enrollment :
101 participants
Time Perspective:
Prospective
Official Title:
Diagnostic Value of Pyrosequencing for the BRAFV600E Mutation in Ultrasound-Guided Fine-Needle Aspiration Biopsy Samples of Thyroid Incidentalomas
Study Start Date :
Jun 1, 2006
Actual Study Completion Date :
Dec 1, 2006

Arms and Interventions

Arm Intervention/Treatment
1

Patients with thyroid incidentaloma underwent ultrasound-guided fine needle aspiration biopsy

Procedure: ultrasound-guided fine needle aspiration biopsy
Fine needle aspiration (FNA)with cytologic analysis has become a mainstay of thyroid nodule evaluation was used. Nonpalpable nodules were aspirated under ultrasound guidance to facilitate precise targeting of the nodule and to sample the part most likely to improve diagnostic yield.

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Patients with thyroid nodule larger than 1 cm, or nodule smaller than 1 cm that required further evaluation because of suspicious ultrasound findings
    Exclusion Criteria:
    • Patients who refuse participation.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Chungnam National University Hospital Daejeon Korea, Republic of 301-721

    Sponsors and Collaborators

    • Chungnam National University

    Investigators

    • Study Director: Minho Shong, M.D., Ph.D., Chungnam National University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00551486
    Other Study ID Numbers:
    • 071027
    First Posted:
    Oct 31, 2007
    Last Update Posted:
    Oct 31, 2007
    Last Verified:
    Oct 1, 2007
    Keywords provided by , ,
    Pyrosequencing
    BRAFV600E mutation
    Thyroid incidentaloma
    Ultrasound-guided fine-needle aspiration biopsy
    Additional relevant MeSH terms:
    Thyroid Neoplasms
    Thyroid Diseases

    Study Results

    No Results Posted as of Oct 31, 2007