Quality of Life of Adult Cancer Survivors Who Have Undergone a Previous Bone Marrow or Peripheral Stem Cell Transplant for a Childhood Hematologic Cancer

Sponsor

Fred Hutchinson Cancer Center (Other)

Overall Status

Completed

CT.gov ID

NCT00126477

Collaborator

National Cancer Institute (NCI) (NIH)

750

Enrollment

Location

168

Duration (Months)

4.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

RATIONALE: Studying quality of life in cancer survivors may help determine the long-term effects of hematologic cancer and may help improve the quality of life for future cancer survivors.

PURPOSE: This clinical trial is studying the quality of life of adult cancer survivors who have undergone a previous bone marrow or peripheral stem cell transplant for a childhood hematologic cancer.

Condition or Disease	Intervention/Treatment	Phase
Leukemia Lymphoma Myelodysplastic Syndromes Quality of Life	Procedure: cognitive assessment Procedure: management of therapy complications Procedure: psychosocial assessment and care Procedure: quality-of-life assessment

Detailed Description

OBJECTIVES:

Determine the extent to which adult cancer survivors who have undergone prior bone marrow or peripheral blood stem cell transplantation for a pediatric hematologic malignancy require ongoing health care and whether these needs change with increasing time after transplantation.
Correlate physical capabilities, body image, physical limitations, including sexuality issues which alter or influence lifestyle, with time after transplantation in these patients.
Determine whether cognitive abilities relative to memory and neurobehavioral ratings change with increasing time after transplantation in these patients.
Correlate social and relationship abilities with length of time after transplantation in these patients.

OUTLINE: Patients and siblings complete a self-report quality of life questionnaire, including outcome assessments of neuroendocrine function, cognitive abilities, physical capability, and psychosocial behavior.

PROJECTED ACCRUAL: Approximately 750 patients (375 adult cancer survivors [case group] and 375 siblings [control group]) will be accrued for this study within 7 years.

Study Design

Study Type:

Observational

Anticipated Enrollment :

750 participants

Official Title:

The Quality of Life of Adult Survivors Who Received a Marrow Transplant as a Child

Study Start Date :

Mar 1, 1996

Actual Primary Completion Date :

Apr 1, 2007

Actual Study Completion Date :

Mar 1, 2010

Outcome Measures

Primary Outcome Measures

Neuroendocrine status of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18 []
Cognitive capability of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18 []
Physical capability of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18 []
Psychosocial status of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18 []

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

DISEASE CHARACTERISTICS:

Case group
Previously treated with an allogeneic, unrelated, syngeneic, or autologous bone marrow or peripheral blood stem cell transplantation for a hematologic malignancy ≥ 5 years ago while enrolled on 1 of the following protocols:
FHCRC-160.06
FHCRC-179.07T
FHCRC-446.03T
FHCRC-661.04
FHCRC-697.00
FHCRC-796.00
FHCRC-843.00
Disease-free survivor
Under 18 years of age at time of transplantation
Any prior preparative regimen allowed
Control group
Sex-matched sibling within 5 years of patient's age*
No chronic illnesses (e.g., cancer, diabetes, or asthma) that require medication
No allergies that limit physical activity NOTE: *If such a sibling is not available, but another sibling is available, then that sibling would be asked to nominate a friend or relative of the same gender as the patient who is also within 5 years of the patient's age; the patient must consent in order for the control subject to participate