pediRES-Q: Quality of Pediatric Resuscitation in a Multicenter Collaborative
Study Details
Study Description
Brief Summary
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.
The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal.
Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Pediatric Cardiac Arrests Pediatric cardiac arrests requiring chest compressions for at least 1 minute managed at clinical centers identified as part of standard clinical operations. |
Outcome Measures
Primary Outcome Measures
- Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR [10 Years]
Primary outcome: "Guideline-compliant CPR" which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. "Guideline-compliant CPR" requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patient received chest compressions for at least 1 minute
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Patient between gestational age ≥37 weeks and 17 years of age
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Patient had a quality of CPR measurements device (eg., Zoll Medical chest compression sensor) in place during chest compressions
Exclusion Criteria:
- Patient on extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Cedars-Sinai Medical Center | Los Angeles | California | United States | |
| 2 | Stanford University | Palo Alto | California | United States | 94304 |
| 3 | All Children's Hospital | Saint Petersburg | Florida | United States | |
| 4 | Children's Healthcare of Atlanta (CHOA) | Atlanta | Georgia | United States | |
| 5 | University of Chicago, Comer Children's Hospital | Chicago | Illinois | United States | 60637 |
| 6 | Albany Medical Center | Albany | New York | United States | |
| 7 | Akron Children's | Akron | Ohio | United States | |
| 8 | Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | United States | |
| 9 | Nationwide Children's Hospital | Columbus | Ohio | United States | |
| 10 | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
| 11 | Medical University of South Carolina | Charleston | South Carolina | United States | |
| 12 | Dell Children's Medical Center | Austin | Texas | United States | |
| 13 | University of Texas Southwestern | Dallas | Texas | United States | |
| 14 | Children's Hospital of Richmond at VCU | Richmond | Virginia | United States | |
| 15 | Seattle Children's Hospital | Seattle | Washington | United States | 98105 |
Sponsors and Collaborators
- Children's Hospital of Philadelphia
- Zoll Medical Corporation
Investigators
- Principal Investigator: Vinay Nadkarni, MD, MS, Children's Hospital of Philadelphia
Study Documents (Full-Text)
None provided.More Information
Publications
- Esangbedo I, Yu P, Raymond T, Niles DE, Hanna R, Zhang X, Wolfe H, Griffis H, Nadkarni V; Pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Pediatric in-hospital CPR quality at night and on weekends. Resuscitation. 2020 Jan 1;146:56-63. doi: 10.1016/j.resuscitation.2019.10.039. Epub 2019 Nov 14.
- Niles DE, Duval-Arnould J, Skellett S, Knight L, Su F, Raymond TT, Sweberg T, Sen AI, Atkins DL, Friess SH, de Caen AR, Kurosawa H, Sutton RM, Wolfe H, Berg RA, Silver A, Hunt EA, Nadkarni VM; pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Characterization of Pediatric In-Hospital Cardiopulmonary Resuscitation Quality Metrics Across an International Resuscitation Collaborative. Pediatr Crit Care Med. 2018 May;19(5):421-432. doi: 10.1097/PCC.0000000000001520.
- Pfeiffer S, Lauridsen KG, Wenger J, Hunt EA, Haskell S, Atkins DL, Duval-Arnould JM, Knight LJ, Cheng A, Gilfoyle E, Su F, Balikai S, Skellett S, Hui MY, Niles DE, Roberts JS, Nadkarni VM, Tegtmeyer K, Dewan M; Pediatric Resuscitation Quality Collaborative Investigators. Code Team Structure and Training in the Pediatric Resuscitation Quality International Collaborative. Pediatr Emerg Care. 2021 Aug 1;37(8):e431-e435. doi: 10.1097/PEC.0000000000001748.
- Sweberg T, Sen AI, Mullan PC, Cheng A, Knight L, Del Castillo J, Ikeyama T, Seshadri R, Hazinski MF, Raymond T, Niles DE, Nadkarni V, Wolfe H; pediatric resuscitation quality (pediRES-Q) collaborative investigators. Description of hot debriefings after in-hospital cardiac arrests in an international pediatric quality improvement collaborative. Resuscitation. 2018 Jul;128:181-187. doi: 10.1016/j.resuscitation.2018.05.015. Epub 2018 May 26.
- Wolfe HA, Wenger J, Sutton R, Seshadri R, Niles DE, Nadkarni V, Duval-Arnould J, Sen AI, Cheng A. Cold Debriefings after In-hospital Cardiac Arrest in an International Pediatric Resuscitation Quality Improvement Collaborative. Pediatr Qual Saf. 2020 Jul 8;5(4):e319. doi: 10.1097/pq9.0000000000000319. eCollection 2020 Jul-Aug.
- 15-012099