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Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)

Sponsor
University of Mississippi Medical Center (Other)
Overall Status
Completed
CT.gov ID
NCT00653809
Collaborator
Office of Minority Health (Other), Mississippi Institute for Improvement of Geographic Minority Health (Other)
52
Enrollment
1
Location
27
Duration (Months)
1.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    52 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Official Title:
    Elucidating the Role of Nitric Oxide and Endothelin-1 Activation in Endothelial Cells Co-cultured With Placental Explants From African-american and Caucasian High Risk Pregnancies
    Study Start Date :
    Jun 1, 2007
    Actual Primary Completion Date :
    Dec 1, 2008
    Actual Study Completion Date :
    Sep 1, 2009

    Arms and Interventions

    Arm Intervention/Treatment
    A, 1, I

    Caucasian women without preeclampsia or PIH, delivering their first child
    A, 1, II

    Caucasian women with preeclampsia or PIH, delivering their first child
    A, 2, I

    African-american women without preeclampsia or PIH, delivering their first child
    A, 2, II

    African-American women with preeclampsia or PIH, delivering their first child
    B, 1, I

    Caucasian women without preeclampsia or PIH, delivering at least their second child
    B, 1, II

    Caucasian women with preeclampsia or PIH, delivering at least their second child
    B, 2, I

    African-american women without preeclampsia or PIH, delivering at least their second child
    B, 2, II

    African-american women with preeclampsia or PIH, delivering at least their second child

    Outcome Measures

    Primary Outcome Measures

    1. Nitric oxide and Endothelin-1 levels [48 hours after tissue collection]

    Secondary Outcome Measures

    1. Nitric oxide isoforms and Endothelin-1 receptor activation based on primary outcome [within 6 months from tissue collection]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 40 Years
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • African-american or Caucasian

    • Pregnant

    • Between ages of 18 - 40 years of age

    Exclusion Criteria:

    • Presence of a disease or condition which is not preeclampsia

    • Drug or alcohol abuse during pregnancy

    • Obesity

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of MS Medical Center Jackson Mississippi United States 39216

    Sponsors and Collaborators

    • University of Mississippi Medical Center
    • Office of Minority Health
    • Mississippi Institute for Improvement of Geographic Minority Health

    Investigators

    • Principal Investigator: Kedra L Wallace, PhD, Obstetrics & Gynecology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Kedra Wallace, Postdoc Research Fellow, University of Mississippi Medical Center
    ClinicalTrials.gov Identifier:
    NCT00653809
    Other Study ID Numbers:
    • 2007-0065
    First Posted:
    Apr 7, 2008
    Last Update Posted:
    Apr 6, 2012
    Last Verified:
    Apr 1, 2012
    Additional relevant MeSH terms:
    Pre-Eclampsia

    Study Results

    No Results Posted as of Apr 6, 2012