Phase III Study of a Topical Gel Formulation for Treatment and Prevention of Raynaud's Phenomenon
Study Details
Study Description
Brief Summary
The purpose of this research study is to test the safety, tolerability, and effectiveness of Topical AmphiMatrix with Nitroglycerin (MQX-503) to relieve Raynaud's symptoms and increase blood flow to the fingers.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
The purpose of this clinical study is to determine, in a controlled fashion, the ability of Topical AmphiMatrix formulation with Nitroglycerin (MQX-503) to improve the patient's health assessment as indicated by patient and physician assessments, decrease the frequency of Raynaud's events, decrease the duration of Raynaud's events, and decrease the symptoms (pain, tingling, numbness) in the fingers of Raynaud's patients. The study will include patients with moderate to severe primary Raynaud's phenomenon and with Raynaud's phenomenon secondary to autoimmune diseases such as scleroderma.
Study Design
Outcome Measures
Primary Outcome Measures
- Reduction in Raynaud's Condition Score []
Secondary Outcome Measures
- Frequency and Severity of adverse events []
Eligibility Criteria
Criteria
Inclusion Criteria:
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Outpatients, 18 years to 70 years.
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Patients with a clinical diagnosis of Raynaud's phenomenon.
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Patients who are willing to discontinue current vasodilator therapies.
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Patients who agree not to use any other investigational medications or approved therapies to treat Raynaud's phenomenon and its symptoms while participating in this study.
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Negative pregnancy test in fertile women.
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Patients who are able to give written informed consent and comply with all study requirements.
Exclusion Criteria:
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Patients who concurrently use any nitrate medication or medications known to interact with Nitroglycerin.
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Patients who concurrently use any medication or device which might interfere with the study medication.
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Patients who have a known allergy to Nitroglycerin or common topical gel ingredients.
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Patients with a history of headaches.
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Patients who have a history of an unstable medical problem.
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Patients with cognitive or language difficulties.
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Patients who, within the past three months, have had either a myocardial infarction, uncontrolled congestive heart failure, unstable angina, uncontrolled hypotension, or uncontrolled hypertension.
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Patients who participated in a study of any investigational drug within four weeks prior to Visit 1.
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Patients who have screening laboratory values which are 20% or greater of the upper or lower limit of normal.
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Patients who have had major surgery within six months of Visit 1.
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Patients with interfering skin conditions.
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Pregnant or nursing women.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Standford Medical School | Stanford | California | United States | 94305 |
| 2 | University of Connecticut | Farmington | Connecticut | United States | 06030 |
| 3 | Georgetown University Medical Center | Washington | District of Columbia | United States | 20007 |
| 4 | Johns Hopkins Bayview Medical Center | Baltimore | Maryland | United States | 21224 |
| 5 | The Center for Rheumatology | Albany | New York | United States | 12206 |
| 6 | Duke University | Durham | North Carolina | United States | 27710 |
| 7 | Lund University Hospital | Lund | Sweden | 221 185 | |
| 8 | Royal National Hospital for Rheumatic Diseases | Bath | United Kingdom | LX1 3EX | |
| 9 | Ninewells Hospital and Medical School | Dundee | United Kingdom | DD1 9SY | |
| 10 | University of Leeds | Leeds | United Kingdom | LS7 4SA | |
| 11 | Royal Free Hospital | London | United Kingdom | NW3 2QH | |
| 12 | Hope Hospital | Salford | United Kingdom | M6 8HD |
Sponsors and Collaborators
- MediQuest Therapeutics
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 06-005