RDRI and NGAL in Acute Kidney Injury in Abdominal Surgery
Study Details
Study Description
Brief Summary
Acute kidney injury (AKI), which can occur after major surgeries, leads to increased morbidity and mortality if not detected and managed promptly. In clinical practice, serum creatinine and urine output values of patients are monitored to detect AKI, but these parameters can cause delays in diagnosis. Additionally, studies have been conducted on biomarkers such as Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cystatin C in recent years, but definitive results have not been achieved.
Renal Doppler Resistive Index (RDRI) is a non-invasive index believed to reflect renal vascular perfusion. RDRI measurement is a repeatable, inexpensive, and easy-to-apply technique. RDRI has been found to be associated with AKI in conditions such as renal dysfunction, hypertension, and post-traumatic hemorrhagic shock. Furthermore, due to the impact on renal perfusion in patients undergoing major surgery, RDRI, which reflects renal vascular resistance, can serve as an indicator of kidney perfusion.
The aim of this study is to test the hypothesis, 'Does measuring postoperative RDRI in major abdominal surgery cases yield higher sensitivity and specificity values in detecting acute kidney injury compared to NGAL?'
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Outcome Measures
Primary Outcome Measures
- Plasma NGAL Level [Postoperative 4th hour]
From patients undergoing major abdominal surgery, a blood sample will be taken at Postop 4th Hour for serum NGAL analysis
- Renal Doppler Resistive Index [Postoperative 4th hour]
Renal Doppler Resistive Index will be measured at the 4th hour after major abdominal surgery.
Eligibility Criteria
Criteria
Inclusion Criteria:
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ASA I-III,
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Patients undergoing elective major abdominal surgery
Exclusion Criteria:
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Chronic kidney failure,
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Using nephrotoxic drugs,
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Patients with a history of kidney transplantation or nephrectomy
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Antalya Training and Research Hospital
Investigators
- Principal Investigator: Erhan OZYURT, Assoc. Prof., Antalya Training and Research Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Muthukrishnan K, Parida S, Barathi SD, Badhe AS, Mishra SK. Doppler resistive index to reflect risk of acute kidney injury after major abdominal surgery: A prospective observational trial. Indian J Anaesth. 2019 Jul;63(7):551-557. doi: 10.4103/ija.IJA_189_19.
- Zeng X, McMahon GM, Brunelli SM, Bates DW, Waikar SS. Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals. Clin J Am Soc Nephrol. 2014 Jan;9(1):12-20. doi: 10.2215/CJN.02730313. Epub 2013 Oct 31.
- Ercan01