Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage

• Sponsor: University of Vienna (Other)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT05220371
• Collaborator: CRI Collagen Research Institute GmbH (Other)
• Enrollment: 50
• Location: 1
• Arms: 2
• Anticipated Duration (Months): 3.1
• Patients Per Site Per Month: 16.4

Study Details

Study Description

Brief Summary

The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.

Condition or Disease	Intervention/Treatment	Phase
Recovery	Dietary Supplement: Collagen; Other: Concurrent training	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 50 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Double (Participant, Investigator)
• Masking Description: Double-blind, randomized controlled trial
• Primary Purpose: Basic Science
• Official Title: Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage
• Actual Study Start Date: Jan 28, 2022
• Anticipated Primary Completion Date: May 1, 2022
• Anticipated Study Completion Date: May 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Collagen 15g of collagen peptides ingested daily	Dietary Supplement: Collagen; Participants ingest 15 grams of either specific collagen peptides or Placebo daily; Other: Concurrent training; Both arms undergo a 12-week trainingintervention 3x/week
Placebo Comparator: Placebo 15g of Placebo ingested daily	Other: Concurrent training; Both arms undergo a 12-week trainingintervention 3x/week

Outcome Measures

Primary Outcome Measures

1. Change in maximal voluntary contraction (MVC) [Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)]

   Measured by isokinetic dynamometer

2. Change in rate of force development (RFD) [Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)]

   Measured by isokinetic dynamometer

3. Change in countermovement jump height (CMJ) [Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)]

   Measured by force plate

4. Change in subjective pain score [Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)]

   Measured by visual analogue scale

5. Change in Achilles tendon cross-sectional area [Baseline and after 12 weeks]

   Measured by ultrasound

6. Change in Vastus Lateralis fibre length [Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)]

   Measured by ultrasound

7. Change in collagen related blood markers [Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)]

   Measured by blood analysis

8. Change in Achilles tendon echo intensity [Baseline and after 12 weeks]

   Measured by ultrasound

9. Change in Vastus Lateralis echo intensity [Baseline and after 12 weeks]

   Measured by ultrasound

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 40 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• No subjective symptoms during physical exertion

• Stable weight and dietary behaviour

• Body Mass Index (BMI) between 18.5 and 24.9

• No extensive strength/endurance sports so far (less than 3 h/week)

• No complaints during strenuous physical activity

Exclusion Criteria:

• Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)

• Intolerance/aversion to animal protein

• Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest

• Presence of insulin-dependent diabetes mellitus

• Liver and/or kidney disease that precludes a high protein load

• Collagen supplementation or regular intake of other dietary supplements in the last 6 months.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Vienna, Institute of Sport Science	Vienna		Austria	1150

Sponsors and Collaborators

• University of Vienna
• CRI Collagen Research Institute GmbH

Investigators

• Principal Investigator: Daniel Koenig, Prof. Dr., University of Vienna, Institute of Sport Science

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Daniel König, Univ.-Prof. Dr. med. Daniel König, University of Vienna
• ClinicalTrials.gov Identifier: NCT05220371
• Other Study ID Numbers: 00765
• First Posted: Feb 2, 2022
• Last Update Posted: May 4, 2022
• Last Verified: Apr 1, 2022

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Daniel König, Univ.-Prof. Dr. med. Daniel König, University of Vienna: Collagen peptides; Concurrent training; Ultrasound; MVC; RFD

Study Results

No Results Posted as of May 4, 2022