Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches
Sponsor
Southwest Oncology Group (Other)
Overall Status
Completed
CT.gov ID
NCT02785913
Collaborator
National Cancer Institute (NCI) (NIH)
31
1111
1
60
0
0
Study Details
Study Description
Brief Summary
This phase II trial studies how well taselisib (GDC-0032) works in treating patients with stage IV squamous cell lung cancer that has come back after previous treatment. This is a sub-study that includes all screened patients positive for the phosphoinositide 3-kinase (PI3K) biomarker. PI3K can cause tumor cells to grow more quickly. Taselisib may decrease the activity of PI3K and may be able to shrink tumors.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Detailed Description
PRIMARY OBJECTIVES:
-
Phase II Component: To evaluate if there is sufficient evidence to continue to the phase III component by evaluating the objective response rate (ORR) for PI3K Genentech (GNE)-positive patients registered to S1400B treated with GDC-0032. (Phase II)
-
Phase III Component: If the study meets the criteria specified in S1400, the study will be amended to include a follow-on randomized phase III trial.
SECONDARY OBJECTIVES:
-
To evaluate investigator-assessed progression free survival (IA-PFS) and overall survival (OS) in both the subset of patients defined to be PI3K GNE-positive and in the entire S1400B (PI3K Foundation Medicine [FMI] positive) study population treated with GDC-0032. (Phase II)
-
To evaluate ORR in the entire S1400B (PI3K FMI positive) study population treated with GDC-0032 to evaluate the duration of response (DoR) both in GNE positive and FMI positive. (Phase II)
-
To evaluate the DoR both in the entire S1400B PI3K FMI positive study population and in GNE positive patients treated with GDC-0032 who achieve a complete response (CR) or partial response (PR) (confirmed and unconfirmed) by Response Evaluation Criteria In Solid Tumors (RECIST) 1.1. (Phase II)
-
To evaluate the frequency and severity of toxicities associated with GDC-0032. (Phase II)
TRANSLATIONAL MEDICINE OBJECTIVES:
-
To identify additional predictive tumor/blood biomarkers that may modify response or define resistance to the GDC-0032 beyond the chosen biomarker for biomarker-driven sub-studies.
-
To identify potential resistance biomarkers at disease progression.
-
To establish a tissue/ blood repository from patients with refractory squamous cell carcinoma (SCCA) of the lung.
OUTLINE: As of 12/18/2015, patients are assigned to Arm I.
ARM I: Patients receive taselisib orally (PO) daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM II (CLOSED TO ACCRUAL 12/18/2015): Patients receive docetaxel intravenously (IV) on day
- Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Upon progression, patients may be eligible to re-register to Arm III.
Re-registration ARM III: Patients in Arm II eligible for re-registration receive taselisib orally (PO) on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, all patients are followed up every 6 months for the first 2 years and then at the end of the year 3 from date of sub-study/re-registration.
Study Design
Study Type:
Interventional
Actual Enrollment
:
31 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K Positive Patients With Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study)
Actual Study Start Date
:
Nov 1, 2014
Actual Primary Completion Date
:
Feb 1, 2017
Actual Study Completion Date
:
Nov 1, 2019
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm I (GDC-0032) Patients receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Taselisib
Given PO
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Objective Response Rate (ORR) for PI3K GNE-positive Participants Registered to S1400B Treated With GDC-0032. [From date of registration to maximum of 3 years.]
ORR-the percentage of PI3K GNE-positive participants with confirmed and unconfirmed, partial response and complete response to treatment with GDC-0032 per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1).
Secondary Outcome Measures
- Investigator-assessed Progression Free Survival (IA-PFS) in Both the Subset of Participants Defined to be PI3K GNE-positive and in the Entire S1400B (PI3K FMI Positive) Study Population Treated With GDC-0032. [From time of registration to maximum of 3 years.]
From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause.
- Investigator-assessed Overall Survival (OS) in Both the Subset of Participants Defined to be PI3K GNE-positive and in the Entire S1400B (PI3K FMI Positive) Study Population Treated With GDC-0032. [From time of registration to maximum of 3 years.]
From date of sub-study registration to date of death due to any cause assessed by local review.
- ORR in the Entire S1400B (PI3K FMI Positive) Study Population Treated With GDC-0032. [From time of registration to maximum of 3 years.]
Per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1).
- Duration of Response (DoR) Both in the Entire S1400B PI3K FMI Positive Study Population and in GNE Positive Participants Treated With GDC-0032 Who Achieve a CR or PR (Confirmed and Unconfirmed) by RECIST 1.1. [From time of registration to maximum of 3 years.]
Among participants who had a response, duration is calculated from registration to response date.
- Frequency and Severity of Toxicities Associated With GDC-0032. (Phase II) [From date of registration to maximum of 3 years.]
Frequency and severity of toxicities greater than Grade 2 associated with GDC-0032.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Patients must meet all SCREENING/PRE-SCREENING and SUB-STUDY REGISTRATION COMMON ELIGIBILITY CRITERIA as specified in S1400: Phase II/III Biomarker-Driven Master Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map)
-
Patients must be assigned to S1400B
-
Hemoglobin A1c (HbA1c) < 7% obtained within 28 days prior to sub-study registration
-
Fasting glucose < 125 mg/dL obtained within 28 days prior to sub-study registration
-
Patients must not have type I or II diabetes that requires anti-hyperglycemic medication
-
Patients must not have active or a history of small or large intestine inflammation such as Crohn's disease or ulcerative colitis
-
Patients must not require daily supplemental oxygen
-
Patients must be able to take oral medications; patients may not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of GDC-0032 (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection)
-
Patients must not be taking, nor plan to take while on protocol treatment and for 14 days post the last dose of study treatment, drugs, herbal supplements or foods that are known to be strong/moderate cytochrome p450, family 3, subfamily A, polypeptide 4 (CYP3A4) substrates
-
Patients must also be offered participation in banking for future use of specimens
-
STEP 2 TO GDC-0032 RE-REGISTRATION:
-
Patients must have progressed on arm 2 (docetaxel) of this sub-study
-
Patients must not have received any prior systemic therapy (systemic chemotherapy, immunotherapy or investigational drug) within 21 days prior to step 2 re-registration; patients must have recovered (< grade 1) from any side effects of prior therapy
-
Patients must have measurable disease documented by computed tomography (CT) or magnetic resonance imaging (MRI); the CT from a combined PET/CT may be used to document only non-measurable disease unless it is of diagnostic quality; measurable disease must be assessed within 28 days prior to step 2 re-registration; pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease; non-measurable disease must be assessed within 42 days prior to step 2 re-registration; all disease must be assessed and documented on the baseline tumor assessment form; patients whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to registration
-
Patients must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to step 2 re-registration; patient must not have leptomeningeal disease, spinal cord compression or brain metastases unless: (1) metastases have been locally treated and have remained clinically controlled and asymptomatic for at least 14 days following treatment, AND (2) patient has no residual neurological dysfunction and has been off corticosteroids for at least 1 day prior to re-registration
-
Patients must not be planning to receive any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment; concurrent use of hormones for non-cancer-related conditions (e.g., insulin for diabetes and hormone replacement therapy) is acceptable
-
Absolute neutrophil count (ANC) >= 1,500/mcl obtained within 28 days prior to step 2 re-registration
-
Platelet count >= 100,000 mcl obtained within 28 days prior to step 2 re-registration
-
Hemoglobin >= 9 g/dL obtained within 28 days prior to step 2 re-registration
-
Serum bilirubin =< institutional upper limit of normal (IULN); for patients with liver metastases, bilirubin must be =< 5 x IULN obtained within 28 days prior to step 2 re-registration
-
Either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN within 28 days prior to step 2 re-registration (if both ALT and AST are done, both must be < 2 IULN); for patients with liver metastases, either ALT or AST must be =< 5 x IULN (if both ALT and AST are done, both must be =< 5 x IULN)
-
HbA1c < 7% obtained within 28 days prior to step 2 re-registration
-
Fasting glucose < 125 mg/dL obtained within 28 days prior to step 2 re-registration
-
Serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/min
-
Patients must have Zubrod performance status of 0-1 documented within 28 days prior to step 2 re-registration
-
Patients must not have any grade III/IV cardiac disease as defined by the New York Heart Association Criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, and myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia
-
Patients must not have documented evidence of acute hepatitis or have an active or uncontrolled infection
-
Patients with a known history of human immunodeficiency virus (HIV) seropositivity: must have undetectable viral load using standard HIV assays in clinical practice; must have cluster of differentiation (CD)4 count >= 400/mcL; must not require prophylaxis for any opportunistic infections (i.e., fungal, mycobacterium avium complex [mAC], or pneumocystis pneumonia [PCP] prophylaxis); must not be newly diagnosed within 12 months prior to re-registration
-
Prestudy history and physical exam must be obtained within 28 days prior to re-registration
-
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years
-
Patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
-
As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
-
Patients with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator)
-
Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 3 | Anchorage Radiation Therapy Center | Anchorage | Alaska | United States | 99504 |
| 4 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 5 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 6 | Alaska Regional Hospital | Anchorage | Alaska | United States | 99508 |
| 7 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
| 8 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 9 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 10 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 11 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 12 | University of Arizona Cancer Center-North Campus | Tucson | Arizona | United States | 85719 |
| 13 | The University of Arizona Medical Center-University Campus | Tucson | Arizona | United States | 85724 |
| 14 | Yuma Cancer Center | Yuma | Arizona | United States | 85364 |
| 15 | Mercy Cancer Center-Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 16 | Fowler Family Center for Cancer Care | Jonesboro | Arkansas | United States | 72401 |
| 17 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 18 | Kaiser Permanente-Anaheim | Anaheim | California | United States | 92807 |
| 19 | Kaiser Permanente-Deer Valley Medical Center | Antioch | California | United States | 94531 |
| 20 | Sutter Auburn Faith Hospital | Auburn | California | United States | 95602 |
| 21 | Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | United States | 95603 |
| 22 | AIS Cancer Center at San Joaquin Community Hospital | Bakersfield | California | United States | 93301 |
| 23 | Kaiser Permanente-Baldwin Park | Baldwin Park | California | United States | 91706 |
| 24 | Kaiser Permanente-Bellflower | Bellflower | California | United States | 90706 |
| 25 | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | United States | 94704 |
| 26 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 27 | Mills-Peninsula Medical Center | Burlingame | California | United States | 94010 |
| 28 | Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | United States | 95682 |
| 29 | Eden Hospital Medical Center | Castro Valley | California | United States | 94546 |
| 30 | City of Hope Corona | Corona | California | United States | 92879 |
| 31 | Sutter Davis Hospital | Davis | California | United States | 95616 |
| 32 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
| 33 | Kaiser Permanente Hospital | Fontana | California | United States | 92335 |
| 34 | Kaiser Permanente-Fremont | Fremont | California | United States | 94538 |
| 35 | Kaiser Permanente | Fresno | California | United States | 93720 |
| 36 | Saint Jude Medical Center | Fullerton | California | United States | 92835 |
| 37 | Kaiser Permanente - Harbor City | Harbor City | California | United States | 90710 |
| 38 | Kaiser Permanente-Irvine | Irvine | California | United States | 92618 |
| 39 | UC San Diego Moores Cancer Center | La Jolla | California | United States | 92093 |
| 40 | City of Hope Antelope Valley | Lancaster | California | United States | 93534 |
| 41 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 42 | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | United States | 90027 |
| 43 | Los Angeles County-USC Medical Center | Los Angeles | California | United States | 90033 |
| 44 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
| 45 | Kaiser Permanente-Cadillac | Los Angeles | California | United States | 90034 |
| 46 | Memorial Medical Center | Modesto | California | United States | 95355 |
| 47 | Kaiser Permanente-Modesto | Modesto | California | United States | 95356 |
| 48 | Community Hospital of Monterey Peninsula | Monterey | California | United States | 93940 |
| 49 | Pacific Cancer Care-Monterey | Monterey | California | United States | 93940 |
| 50 | Palo Alto Medical Foundation-Camino Division | Mountain View | California | United States | 94040 |
| 51 | Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View | California | United States | 94040 |
| 52 | Sutter Cancer Research Consortium | Novato | California | United States | 94945 |
| 53 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 54 | Saint Joseph Hospital - Orange | Orange | California | United States | 92868 |
| 55 | Palo Alto Medical Foundation Health Care | Palo Alto | California | United States | 94301 |
| 56 | Kaiser Permanente - Panorama City | Panorama City | California | United States | 91402 |
| 57 | Feather River Cancer Center | Paradise | California | United States | 95969 |
| 58 | PCR Oncology | Pismo Beach | California | United States | 93449 |
| 59 | City of Hope Rancho Cucamonga | Rancho Cucamonga | California | United States | 91730 |
| 60 | Eisenhower Medical Center | Rancho Mirage | California | United States | 92270 |
| 61 | Kaiser Permanente-Redwood City | Redwood City | California | United States | 94063 |
| 62 | Kaiser Permanente-Richmond | Richmond | California | United States | 94801 |
| 63 | Kaiser Permanente-Riverside | Riverside | California | United States | 92505 |
| 64 | Kaiser Permanente-Roseville | Roseville | California | United States | 95661 |
| 65 | Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | United States | 95661 |
| 66 | Sutter Roseville Medical Center | Roseville | California | United States | 95661 |
| 67 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 68 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 69 | Kaiser Permanente-South Sacramento | Sacramento | California | United States | 95823 |
| 70 | Kaiser Permanente - Sacramento | Sacramento | California | United States | 95825 |
| 71 | Saint Helena Hospital | Saint Helena | California | United States | 94574 |
| 72 | Kaiser Permanente-San Diego Mission | San Diego | California | United States | 92108 |
| 73 | Kaiser Permanente-San Diego Zion | San Diego | California | United States | 92120 |
| 74 | California Pacific Medical Center-Pacific Campus | San Francisco | California | United States | 94115 |
| 75 | Kaiser Permanente-San Francisco | San Francisco | California | United States | 94115 |
| 76 | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | United States | 95119 |
| 77 | Kaiser Permanente San Leandro | San Leandro | California | United States | 94577 |
| 78 | Kaiser Permanente-San Marcos | San Marcos | California | United States | 92069 |
| 79 | Kaiser Permanente-San Rafael | San Rafael | California | United States | 94903 |
| 80 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051 |
| 81 | Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California | United States | 95065 |
| 82 | Kaiser Permanente-Santa Rosa | Santa Rosa | California | United States | 95403 |
| 83 | Sutter Pacific Medical Foundation | Santa Rosa | California | United States | 95403 |
| 84 | City of Hope South Pasadena | South Pasadena | California | United States | 91030 |
| 85 | Kaiser Permanente-South San Francisco | South San Francisco | California | United States | 94080 |
| 86 | Kaiser Permanente-Stockton | Stockton | California | United States | 95210 |
| 87 | Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California | United States | 94086 |
| 88 | Northbay Cancer Center | Vacaville | California | United States | 95687 |
| 89 | Sutter Cancer Centers Radiation Oncology Services-Vacaville | Vacaville | California | United States | 95687 |
| 90 | Kaiser Permanente Medical Center-Vacaville | Vacaville | California | United States | 95688 |
| 91 | Kaiser Permanente-Vallejo | Vallejo | California | United States | 94589 |
| 92 | Sutter Solano Medical Center/Cancer Center | Vallejo | California | United States | 94589 |
| 93 | Kaiser Permanente-Walnut Creek | Walnut Creek | California | United States | 94596 |
| 94 | Presbyterian Intercommunity Hospital | Whittier | California | United States | 90602 |
| 95 | Kaiser Permanente | Woodland Hills | California | United States | 91367 |
| 96 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 97 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 98 | University of Colorado Cancer Center - Anschutz Cancer Pavilion | Aurora | Colorado | United States | 80045 |
| 99 | Boulder Community Hospital | Boulder | Colorado | United States | 80301 |
| 100 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 101 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 102 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
| 103 | Memorial Hospital Central | Colorado Springs | Colorado | United States | 80909 |
| 104 | Denver Health Medical Center | Denver | Colorado | United States | 80204 |
| 105 | Kaiser Permanente-Franklin | Denver | Colorado | United States | 80205 |
| 106 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 107 | Colorado Blood Cancer Institute | Denver | Colorado | United States | 80218 |
| 108 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 109 | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | United States | 80218 |
| 110 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 111 | Rocky Mountain Cancer Centers-Rose | Denver | Colorado | United States | 80220 |
| 112 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 113 | Colorado Cancer Research Program NCORP | Denver | Colorado | United States | 80222 |
| 114 | Mercy Medical Center | Durango | Colorado | United States | 81301 |
| 115 | Southwest Oncology PC | Durango | Colorado | United States | 81301 |
| 116 | Comprehensive Cancer Care and Research Institute of Colorado LLC | Englewood | Colorado | United States | 80113 |
| 117 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 118 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 119 | Mountain Blue Cancer Care Center | Golden | Colorado | United States | 80401 |
| 120 | National Jewish Health-Western Hematology Oncology | Golden | Colorado | United States | 80401 |
| 121 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 122 | Rocky Mountain Cancer Centers-Greenwood Village | Greenwood Village | Colorado | United States | 80111 |
| 123 | Kaiser Permanente-Rock Creek | Lafayette | Colorado | United States | 80026 |
| 124 | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado | United States | 80228 |
| 125 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
| 126 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 127 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 128 | Kaiser Permanente-Lone Tree | Lone Tree | Colorado | United States | 80124 |
| 129 | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | United States | 80124 |
| 130 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 131 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 132 | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | United States | 80501 |
| 133 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 134 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 135 | Rocky Mountain Cancer Centers-Parker | Parker | Colorado | United States | 80138 |
| 136 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
| 137 | Rocky Mountain Cancer Centers - Pueblo | Pueblo | Colorado | United States | 81008 |
| 138 | Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | United States | 80260 |
| 139 | SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 140 | Danbury Hospital | Danbury | Connecticut | United States | 06810 |
| 141 | Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | United States | 06418 |
| 142 | Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut | United States | 06824 |
| 143 | Medical Oncology and Hematology Group PC-Guilford | Guilford | Connecticut | United States | 06437 |
| 144 | Hartford Hospital | Hartford | Connecticut | United States | 06102 |
| 145 | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | United States | 06105 |
| 146 | Midstate Medical Center | Meriden | Connecticut | United States | 06451 |
| 147 | The Hospital of Central Connecticut | New Britain | Connecticut | United States | 06050 |
| 148 | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | United States | 06510 |
| 149 | Yale-New Haven Hospital Saint Raphael Campus | New Haven | Connecticut | United States | 06511 |
| 150 | Yale University | New Haven | Connecticut | United States | 06520 |
| 151 | Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | United States | 06473 |
| 152 | Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | United States | 06360 |
| 153 | Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut | United States | 06477 |
| 154 | Charlotte Hungerford Hospital Center for Cancer Care | Torrington | Connecticut | United States | 06790 |
| 155 | Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | United States | 06611 |
| 156 | Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut | United States | 06708 |
| 157 | Veterans Affairs Connecticut Healthcare System-West Haven Campus | West Haven | Connecticut | United States | 06516 |
| 158 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 159 | Christiana Gynecologic Oncology LLC | Newark | Delaware | United States | 19713 |
| 160 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
| 161 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 162 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 163 | Regional Hematology and Oncology PA | Newark | Delaware | United States | 19713 |
| 164 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 165 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 166 | Nanticoke Memorial Hospital | Seaford | Delaware | United States | 19973 |
| 167 | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | United States | 19801 |
| 168 | MedStar Georgetown University Hospital | Washington | District of Columbia | United States | 20007 |
| 169 | Sibley Memorial Hospital | Washington | District of Columbia | United States | 20016 |
| 170 | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | United States | 33442 |
| 171 | Holy Cross Hospital | Fort Lauderdale | Florida | United States | 33308 |
| 172 | University of Florida | Gainesville | Florida | United States | 32610 |
| 173 | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | United States | 33021 |
| 174 | UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood | Florida | United States | 33021 |
| 175 | Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 176 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 177 | Ocala Oncology Center | Ocala | Florida | United States | 34471 |
| 178 | Memorial Hospital West | Pembroke Pines | Florida | United States | 33028 |
| 179 | Sacred Heart Hospital | Pensacola | Florida | United States | 32504 |
| 180 | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | United States | 33324 |
| 181 | Moffitt Cancer Center | Tampa | Florida | United States | 33612 |
| 182 | Phoebe Putney Memorial Hospital | Albany | Georgia | United States | 31701 |
| 183 | University Cancer and Blood Center LLC | Athens | Georgia | United States | 30607 |
| 184 | Emory University Hospital Midtown | Atlanta | Georgia | United States | 30308 |
| 185 | Piedmont Hospital | Atlanta | Georgia | United States | 30309 |
| 186 | Emory University/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 187 | Northside Hospital | Atlanta | Georgia | United States | 30342 |
| 188 | Saint Joseph's Hospital of Atlanta | Atlanta | Georgia | United States | 30342 |
| 189 | Augusta University Medical Center | Augusta | Georgia | United States | 30912 |
| 190 | John B Amos Cancer Center | Columbus | Georgia | United States | 31904 |
| 191 | Northside Hospital-Forsyth | Cumming | Georgia | United States | 30041 |
| 192 | Dekalb Medical Center | Decatur | Georgia | United States | 30033 |
| 193 | Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia | United States | 30501 |
| 194 | Medical Center of Central Georgia | Macon | Georgia | United States | 31201 |
| 195 | Harbin Clinic Medical Oncology and Clinical Research | Rome | Georgia | United States | 30165 |
| 196 | Memorial University Medical Center | Savannah | Georgia | United States | 31404 |
| 197 | Summit Cancer Care-Memorial | Savannah | Georgia | United States | 31404 |
| 198 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 199 | Low Country Cancer Care Associates PC | Savannah | Georgia | United States | 31405 |
| 200 | South Georgia Medical Center/Pearlman Cancer Center | Valdosta | Georgia | United States | 31602 |
| 201 | Hawaii Oncology Inc-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 202 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 203 | The Cancer Center of Hawaii-Leeward | 'Ewa Beach | Hawaii | United States | 96706 |
| 204 | Hawaii Cancer Care Inc-POB II | Honolulu | Hawaii | United States | 96813 |
| 205 | Hawaii Oncology Inc-POB I | Honolulu | Hawaii | United States | 96813 |
| 206 | Island Urology | Honolulu | Hawaii | United States | 96813 |
| 207 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 208 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 209 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 210 | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States | 96817 |
| 211 | Hawaii Oncology Inc-Kuakini | Honolulu | Hawaii | United States | 96817 |
| 212 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 213 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 214 | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | United States | 96819 |
| 215 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 216 | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | United States | 96766 |
| 217 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 218 | Saint Luke's Mountain States Tumor Institute | Boise | Idaho | United States | 83712 |
| 219 | Kootenai Medical Center | Coeur d'Alene | Idaho | United States | 83814 |
| 220 | Saint Luke's Mountain States Tumor Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 221 | Saint Joseph Regional Medical Center | Lewiston | Idaho | United States | 83501 |
| 222 | Saint Luke's Mountain States Tumor Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 223 | Saint Luke's Mountain States Tumor Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 224 | Kootenai Cancer Center | Post Falls | Idaho | United States | 83854 |
| 225 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 226 | Saint Luke's Mountain States Tumor Institute-Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 227 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 228 | Saint Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 229 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 230 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 231 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 232 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 233 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 234 | Mount Sinai Hospital Medical Center | Chicago | Illinois | United States | 60608 |
| 235 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 236 | John H Stroger Jr Hospital of Cook County | Chicago | Illinois | United States | 60612 |
| 237 | Rush University Medical Center | Chicago | Illinois | United States | 60612 |
| 238 | Swedish Covenant Hospital | Chicago | Illinois | United States | 60625 |
| 239 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 240 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 241 | Cancer Care Center of Decatur | Decatur | Illinois | United States | 62526 |
| 242 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 243 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 244 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 245 | AMITA Health Alexian Brothers Medical Center | Elk Grove Village | Illinois | United States | 60007 |
| 246 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 247 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 248 | Saint Francis Hospital | Evanston | Illinois | United States | 60202 |
| 249 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 250 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 251 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 252 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 253 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 254 | Hematology Oncology Associates of Illinois-Highland Park | Highland Park | Illinois | United States | 60035 |
| 255 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 256 | Hines Veterans Administration Hospital | Hines | Illinois | United States | 60141 |
| 257 | Presence Saint Mary's Hospital | Kankakee | Illinois | United States | 60901 |
| 258 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 259 | NorthShore Hematology Oncology-Libertyville | Libertyville | Illinois | United States | 60048 |
| 260 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 261 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 262 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 263 | Trinity Medical Center | Moline | Illinois | United States | 61265 |
| 264 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 265 | Hematology Oncology Consultants Limited | Naperville | Illinois | United States | 60540 |
| 266 | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | United States | 60451 |
| 267 | Illinois Cancer Specialists-Niles | Niles | Illinois | United States | 60714 |
| 268 | Community Cancer Center Foundation | Normal | Illinois | United States | 61761 |
| 269 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 270 | Radiation Oncology of Northern Illinois | Ottawa | Illinois | United States | 61350 |
| 271 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 272 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
| 273 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61603 |
| 274 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 275 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 276 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 277 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 278 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 279 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 280 | Hematology Oncology Associates of Illinois - Skokie | Skokie | Illinois | United States | 60076 |
| 281 | North Shore Medical Center | Skokie | Illinois | United States | 60076 |
| 282 | Central Illinois Hematology Oncology Center | Springfield | Illinois | United States | 62702 |
| 283 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 284 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 285 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 286 | Cancer Care Specialists of Illinois-Swansea | Swansea | Illinois | United States | 62226 |
| 287 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 288 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 289 | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | United States | 60555 |
| 290 | Rush-Copley Healthcare Center | Yorkville | Illinois | United States | 60560 |
| 291 | Michiana Hematology Oncology PC-Crown Point | Crown Point | Indiana | United States | 46307 |
| 292 | Michiana Hematology Oncology PC-Elkhart | Elkhart | Indiana | United States | 46514 |
| 293 | IU Health Central Indiana Cancer Centers-Fishers | Fishers | Indiana | United States | 46037 |
| 294 | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States | 46202 |
| 295 | Richard L. Roudebush Veterans Affairs Medical Center | Indianapolis | Indiana | United States | 46202 |
| 296 | Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana | United States | 46202 |
| 297 | IU Health Central Indiana Cancer Centers-East | Indianapolis | Indiana | United States | 46219 |
| 298 | Franciscan Health Indianapolis | Indianapolis | Indiana | United States | 46237 |
| 299 | Springmill Medical Center | Indianapolis | Indiana | United States | 46290 |
| 300 | IU Health Arnett Cancer Care | Lafayette | Indiana | United States | 47904 |
| 301 | Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | United States | 46360 |
| 302 | Woodland Cancer Care Center | Michigan City | Indiana | United States | 46360 |
| 303 | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana | United States | 46545 |
| 304 | Michiana Hematology Oncology PC-Mishawaka | Mishawaka | Indiana | United States | 46545 |
| 305 | Franciscan Health Mooresville | Mooresville | Indiana | United States | 46158 |
| 306 | The Community Hospital | Munster | Indiana | United States | 46321 |
| 307 | Michiana Hematology Oncology PC-Plymouth | Plymouth | Indiana | United States | 46563 |
| 308 | Reid Health | Richmond | Indiana | United States | 47374 |
| 309 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 310 | Michiana Hematology Oncology PC-South Bend | South Bend | Indiana | United States | 46601 |
| 311 | Northern Indiana Cancer Research Consortium | South Bend | Indiana | United States | 46628 |
| 312 | Union Hospital | Terre Haute | Indiana | United States | 47804 |
| 313 | Michiana Hematology Oncology PC-Westville | Westville | Indiana | United States | 46391 |
| 314 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 315 | McFarland Clinic PC-William R Bliss Cancer Center | Ames | Iowa | United States | 50010 |
| 316 | Hematology Oncology Associates-Quad Cities | Bettendorf | Iowa | United States | 52722 |
| 317 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 318 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 319 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 320 | Alegent Health Mercy Hospital | Council Bluffs | Iowa | United States | 51503 |
| 321 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 322 | Genesis Medical Center - East Campus | Davenport | Iowa | United States | 52803 |
| 323 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 324 | Iowa-Wide Oncology Research Coalition NCORP | Des Moines | Iowa | United States | 50309 |
| 325 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 326 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 327 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 328 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 329 | JCHC McCreery Cancer Center | Fairfield | Iowa | United States | 52556 |
| 330 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 331 | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242 |
| 332 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 333 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 334 | Ottumwa Regional Health Center | Ottumwa | Iowa | United States | 52501 |
| 335 | Siouxland Regional Cancer Center | Sioux City | Iowa | United States | 51101 |
| 336 | Covenant Medical Center | Waterloo | Iowa | United States | 50702 |
| 337 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 338 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 339 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
| 340 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 341 | Cancer Center of Kansas - El Dorado | El Dorado | Kansas | United States | 67042 |
| 342 | Newman Regional Health | Emporia | Kansas | United States | 66801 |
| 343 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
| 344 | Saint Catherine Hospital | Garden City | Kansas | United States | 67846 |
| 345 | Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas | United States | 67530 |
| 346 | Hays Medical Center | Hays | Kansas | United States | 67601 |
| 347 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 348 | University of Kansas Cancer Center-West | Kansas City | Kansas | United States | 66112 |
| 349 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 350 | Cancer Center of Kansas-Kingman | Kingman | Kansas | United States | 67068 |
| 351 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 352 | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas | United States | 66219 |
| 353 | Minimally Invasive Surgery Hospital | Lenexa | Kansas | United States | 66219 |
| 354 | Cancer Center of Kansas-Liberal | Liberal | Kansas | United States | 67905 |
| 355 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
| 356 | Olathe Medical Center | Olathe | Kansas | United States | 66061 |
| 357 | Menorah Medical Center | Overland Park | Kansas | United States | 66209 |
| 358 | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | United States | 66210 |
| 359 | Saint Luke's South Hospital | Overland Park | Kansas | United States | 66213 |
| 360 | Cancer Center of Kansas - Parsons | Parsons | Kansas | United States | 67357 |
| 361 | Via Christi Hospital-Pittsburg | Pittsburg | Kansas | United States | 66762 |
| 362 | Kansas City NCI Community Oncology Research Program | Prairie Village | Kansas | United States | 66208 |
| 363 | Cancer Center of Kansas - Pratt | Pratt | Kansas | United States | 67124 |
| 364 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
| 365 | Salina Regional Health Center | Salina | Kansas | United States | 67401 |
| 366 | Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas | United States | 66606 |
| 367 | Saint Francis Hospital and Medical Center - Topeka | Topeka | Kansas | United States | 66606 |
| 368 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
| 369 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
| 370 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 371 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
| 372 | Via Christi Regional Medical Center | Wichita | Kansas | United States | 67214 |
| 373 | Wichita NCI Community Oncology Research Program | Wichita | Kansas | United States | 67214 |
| 374 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
| 375 | King's Daughter's Medical Center | Ashland | Kentucky | United States | 41101 |
| 376 | Flaget Memorial Hospital | Bardstown | Kentucky | United States | 40004 |
| 377 | Baptist Health Corbin | Corbin | Kentucky | United States | 40701 |
| 378 | Commonwealth Cancer Center-Corbin | Corbin | Kentucky | United States | 40701 |
| 379 | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky | United States | 41017 |
| 380 | Hardin Memorial Hospital | Elizabethtown | Kentucky | United States | 42701 |
| 381 | Baptist Health Lexington | Lexington | Kentucky | United States | 40503 |
| 382 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
| 383 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 384 | University of Kentucky/Markey Cancer Center | Lexington | Kentucky | United States | 40536 |
| 385 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
| 386 | Norton Hospital Pavilion and Medical Campus | Louisville | Kentucky | United States | 40202 |
| 387 | Baptist Health Louisville | Louisville | Kentucky | United States | 40207 |
| 388 | Norton Suburban Hospital and Medical Campus | Louisville | Kentucky | United States | 40207 |
| 389 | Saints Mary and Elizabeth Hospital | Louisville | Kentucky | United States | 40215 |
| 390 | Norton Audubon Hospital and Medical Campus | Louisville | Kentucky | United States | 40217 |
| 391 | Norton Brownsboro Hospital and Medical Campus | Louisville | Kentucky | United States | 40241 |
| 392 | Jewish Hospital Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
| 393 | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 394 | Baptist Health Paducah | Paducah | Kentucky | United States | 42003 |
| 395 | Jewish Hospital Medical Center South | Shepherdsville | Kentucky | United States | 40165 |
| 396 | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | United States | 70805 |
| 397 | Baton Rouge General Medical Center | Baton Rouge | Louisiana | United States | 70806 |
| 398 | Hematology/Oncology Clinic LLP | Baton Rouge | Louisiana | United States | 70809 |
| 399 | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana | United States | 70809 |
| 400 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 401 | Medical Oncology LLC | Baton Rouge | Louisiana | United States | 70809 |
| 402 | Ochsner Health Center-Summa | Baton Rouge | Louisiana | United States | 70809 |
| 403 | Mary Bird Cancer Center/Saint Tammany Parish | Covington | Louisiana | United States | 70433 |
| 404 | Mary Bird Perkins Cancer Center/Terrebonne General Medical Center | Houma | Louisiana | United States | 70360 |
| 405 | Ochsner Medical Center Kenner | Kenner | Louisiana | United States | 70065 |
| 406 | West Jefferson Medical Center | Marrero | Louisiana | United States | 70072 |
| 407 | East Jefferson General Hospital | Metairie | Louisiana | United States | 70006 |
| 408 | Robert Veith MD LLC | Metairie | Louisiana | United States | 70006 |
| 409 | University Health-Conway | Monroe | Louisiana | United States | 71202 |
| 410 | Louisiana State University Health Science Center | New Orleans | Louisiana | United States | 70112 |
| 411 | Tulane University Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 412 | University Medical Center New Orleans | New Orleans | Louisiana | United States | 70112 |
| 413 | LSU Healthcare Network/Saint Charles | New Orleans | Louisiana | United States | 70115 |
| 414 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 415 | Louisiana State University Health Sciences Center Shreveport | Shreveport | Louisiana | United States | 71103 |
| 416 | Harold Alfond Center for Cancer Care | Augusta | Maine | United States | 04330 |
| 417 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 418 | Lafayette Family Cancer Center-EMMC | Brewer | Maine | United States | 04412 |
| 419 | Mercy Hospital | Portland | Maine | United States | 04101 |
| 420 | Penobscot Bay Medical Center | Rockport | Maine | United States | 04856 |
| 421 | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | United States | 21201 |
| 422 | Greater Baltimore Medical Center | Baltimore | Maryland | United States | 21204 |
| 423 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 424 | MedStar Union Memorial Hospital | Baltimore | Maryland | United States | 21218 |
| 425 | Saint Agnes Hospital | Baltimore | Maryland | United States | 21229 |
| 426 | MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland | United States | 21237 |
| 427 | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States | 21287 |
| 428 | Upper Chesapeake Medical Center | Bel Air | Maryland | United States | 21014 |
| 429 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889-5600 |
| 430 | Western Maryland Regional Medical Center | Cumberland | Maryland | United States | 21502 |
| 431 | Frederick Memorial Hospital | Frederick | Maryland | United States | 21701 |
| 432 | Montgomery General Hospital-Olney | Olney | Maryland | United States | 20832 |
| 433 | Northwest Hospital Center | Randallstown | Maryland | United States | 21133 |
| 434 | Peninsula Regional Medical Center | Salisbury | Maryland | United States | 21801 |
| 435 | William E Kahlert Regional Cancer Center/Sinai Hospital | Westminster | Maryland | United States | 21157 |
| 436 | Beverly Hospital | Beverly | Massachusetts | United States | 01915 |
| 437 | Massachusetts General Hospital Cancer Center | Boston | Massachusetts | United States | 02114 |
| 438 | Boston Medical Center | Boston | Massachusetts | United States | 02118 |
| 439 | Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02215 |
| 440 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02215 |
| 441 | Lahey Hospital and Medical Center | Burlington | Massachusetts | United States | 01805 |
| 442 | Simonds-Sinon Regional Cancer Center | Fitchburg | Massachusetts | United States | 01420 |
| 443 | Addison Gilbert Hospital | Gloucester | Massachusetts | United States | 01930 |
| 444 | Lowell General Hospital | Lowell | Massachusetts | United States | 01854 |
| 445 | Dana-Farber/Brigham and Women's Cancer Center at Milford Regional | Milford | Massachusetts | United States | 01757 |
| 446 | Dana-Farber/Brigham and Women's Cancer Center at South Shore | South Weymouth | Massachusetts | United States | 02190 |
| 447 | Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 448 | Winchester Hospital | Winchester | Massachusetts | United States | 01890 |
| 449 | University of Massachusetts Medical School | Worcester | Massachusetts | United States | 01655 |
| 450 | Veteran's Administration Medical Center - Ann Arbor | Ann Arbor | Michigan | United States | 48105 |
| 451 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106-0995 |
| 452 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 453 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 454 | Beaumont Hospital-Dearborn | Dearborn | Michigan | United States | 48124 |
| 455 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 456 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 457 | Saint John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
| 458 | Green Bay Oncology - Escanaba | Escanaba | Michigan | United States | 49829 |
| 459 | Weisberg Cancer Treatment Center | Farmington Hills | Michigan | United States | 48334 |
| 460 | Botsford General Hospital | Farmington | Michigan | United States | 48334 |
| 461 | Hurley Medical Center | Flint | Michigan | United States | 48502 |
| 462 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 463 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 464 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 465 | William Beaumont Hospital-Grosse Point | Grosse Pointe | Michigan | United States | 48230 |
| 466 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 467 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49001 |
| 468 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 469 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 470 | Saint Mary Mercy Hospital | Livonia | Michigan | United States | 48154 |
| 471 | Mid-Michigan Medical Center - Midland | Midland | Michigan | United States | 48670 |
| 472 | Monroe Cancer Center | Monroe | Michigan | United States | 48162 |
| 473 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 474 | Lakeland Community Hospital | Niles | Michigan | United States | 49120 |
| 475 | Assarian Cancer Center | Novi | Michigan | United States | 48374-1236 |
| 476 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
| 477 | Lake Huron Medical Center | Port Huron | Michigan | United States | 48060 |
| 478 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 479 | Michigan Cancer Specialists | Roseville | Michigan | United States | 48066 |
| 480 | Oakland Colon and Rectal Association | Royal Oak | Michigan | United States | 48067 |
| 481 | Cancer Care Associates PC | Royal Oak | Michigan | United States | 48073 |
| 482 | Comprehensive Medical Center PLLC | Royal Oak | Michigan | United States | 48073 |
| 483 | Hematology Oncology Consultants PC | Royal Oak | Michigan | United States | 48073 |
| 484 | Oakland Medical Group | Royal Oak | Michigan | United States | 48073 |
| 485 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 486 | Saint Mary's of Michigan | Saginaw | Michigan | United States | 48601 |
| 487 | Lakeland Hospital | Saint Joseph | Michigan | United States | 49085 |
| 488 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 489 | Providence Hospital-Southfield Cancer Center | Southfield | Michigan | United States | 48075 |
| 490 | Premier Hematology Oncology Care | Sterling Heights | Michigan | United States | 48312 |
| 491 | Mitchell Folbe MD PC | Sterling Heights | Michigan | United States | 48314 |
| 492 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 493 | Michigan Institute of Urology-Town Center | Troy | Michigan | United States | 48084 |
| 494 | Claudia BR Herke MD PC | Troy | Michigan | United States | 48085 |
| 495 | Hematology Oncology Consultants PC-Troy | Troy | Michigan | United States | 48098 |
| 496 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48098 |
| 497 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 498 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 499 | Sanford Clinic North-Bemidgi | Bemidji | Minnesota | United States | 56601 |
| 500 | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
| 501 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 502 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 503 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 504 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 505 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 506 | Fairview-Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 507 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
| 508 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 509 | Hutchinson Area Health Care | Hutchinson | Minnesota | United States | 55350 |
| 510 | Fairview Maple Grove Medical Center | Maple Grove | Minnesota | United States | 55369 |
| 511 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 512 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 513 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 514 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 515 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 516 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 517 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 518 | Mayo Clinic | Rochester | Minnesota | United States | 55905 |
| 519 | Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | United States | 55416 |
| 520 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 521 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 522 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 523 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 524 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 525 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 526 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 527 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 528 | Fairview Lakes Medical Center | Wyoming | Minnesota | United States | 55092 |
| 529 | Baptist Cancer Center-Golden Triangle | Columbus | Mississippi | United States | 39705 |
| 530 | Boston Baskin Cancer Center-Grenada | Grenada | Mississippi | United States | 38901 |
| 531 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216 |
| 532 | Family Cancer Center-Oxford | Oxford | Mississippi | United States | 38655 |
| 533 | Family Cancer Center-Southhaven | Southaven | Mississippi | United States | 38671 |
| 534 | Baptist Memorial Hospital-Desoto | Southhaven | Mississippi | United States | 38671 |
| 535 | Baptist Cancer Institute-Starkville | Starkville | Mississippi | United States | 39759 |
| 536 | Central Care Cancer Center-Carrie J Babb Cancer Center | Bolivar | Missouri | United States | 65613 |
| 537 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 538 | CoxHealth Cancer Center | Branson | Missouri | United States | 65616 |
| 539 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 540 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 541 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 542 | University of Missouri - Ellis Fischel | Columbia | Missouri | United States | 65212 |
| 543 | Barnes-Jewish West County Hospital | Creve Coeur | Missouri | United States | 63141 |
| 544 | Centerpoint Medical Center LLC | Independence | Missouri | United States | 64057 |
| 545 | Capital Region Medical Center-Goldschmidt Cancer Center | Jefferson City | Missouri | United States | 65109 |
| 546 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 547 | Mercy Hospital-Joplin | Joplin | Missouri | United States | 64804 |
| 548 | Truman Medical Center | Kansas City | Missouri | United States | 64108 |
| 549 | Saint Luke's Hospital of Kansas City | Kansas City | Missouri | United States | 64111 |
| 550 | Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | United States | 64118 |
| 551 | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri | United States | 64128 |
| 552 | The University of Kansas Cancer Center-South | Kansas City | Missouri | United States | 64131 |
| 553 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 554 | The University of Kansas Cancer Center-North | Kansas City | Missouri | United States | 64154 |
| 555 | The University of Kansas Cancer Center-Lee's Summit | Lee's Summit | Missouri | United States | 64064 |
| 556 | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | United States | 64086 |
| 557 | Liberty Radiation Oncology Center | Liberty | Missouri | United States | 64068 |
| 558 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 559 | Saint John's Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 560 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 561 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 562 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 563 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 564 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 565 | Siteman Cancer Center - Saint Peters | Saint Peters | Missouri | United States | 63376 |
| 566 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 567 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 568 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 569 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 570 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 571 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 572 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 573 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 574 | Montana Cancer Consortium NCORP | Billings | Montana | United States | 59102 |
| 575 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 576 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 577 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 578 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 579 | Saint Peter's Community Hospital | Helena | Montana | United States | 59601 |
| 580 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 581 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 582 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 583 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 584 | Heartland Hematology and Oncology | Kearney | Nebraska | United States | 68845 |
| 585 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 586 | Nebraska Hematology and Oncology | Lincoln | Nebraska | United States | 68506 |
| 587 | Nebraska Cancer Research Center | Lincoln | Nebraska | United States | 68510 |
| 588 | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | United States | 68510 |
| 589 | Southeast Nebraska Cancer Center | Lincoln | Nebraska | United States | 68510 |
| 590 | Faith Regional Medical Offices West | Norfolk | Nebraska | United States | 68701 |
| 591 | Great Plains Regional Medical Center | North Platte | Nebraska | United States | 69103 |
| 592 | Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68106 |
| 593 | Nebraska Methodist Hospital | Omaha | Nebraska | United States | 68114 |
| 594 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 595 | Hemotology and Oncology Consultants PC | Omaha | Nebraska | United States | 68122 |
| 596 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 597 | Oncology Hematology West | Omaha | Nebraska | United States | 68124 |
| 598 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 599 | Oncology Hematology West PC | Omaha | Nebraska | United States | 68130 |
| 600 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 601 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 602 | Midlands Community Hospital | Papillion | Nebraska | United States | 68046 |
| 603 | Regional West Medical Center | Scottsbluff | Nebraska | United States | 69361 |
| 604 | Carson Tahoe Regional Medical Center | Carson City | Nevada | United States | 89703 |
| 605 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
| 606 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 607 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 608 | 21st Century Oncology - Henderson | Henderson | Nevada | United States | 89074 |
| 609 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 610 | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada | United States | 89106 |
| 611 | Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | United States | 89106 |
| 612 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 613 | 21st Century Oncology | Las Vegas | Nevada | United States | 89109 |
| 614 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
| 615 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
| 616 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 617 | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada | United States | 89121 |
| 618 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 619 | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 620 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 621 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 622 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 623 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 624 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 625 | 21st Century Oncology - Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 626 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 627 | Nevada Cancer Specialists-Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 628 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
| 629 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 630 | University Cancer Center | Las Vegas | Nevada | United States | 89169 |
| 631 | 21st Century Oncology - Vegas Tenaya | Las Vegas | Nevada | United States | 89182 |
| 632 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 633 | Alpine Hematology-Oncology | Reno | Nevada | United States | 89503 |
| 634 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 635 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 636 | Reno Oncology Consultants | Reno | Nevada | United States | 89519 |
| 637 | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire | United States | 03301 |
| 638 | New Hampshire Oncology Hematology PA-Hooksett | Hooksett | New Hampshire | United States | 03106 |
| 639 | LRGHealthcare-Lakes Region General Hospital | Laconia | New Hampshire | United States | 03246 |
| 640 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 641 | Norris Cotton Cancer Center-Manchester | Manchester | New Hampshire | United States | 03102 |
| 642 | Ocean Medical Center | Brick | New Jersey | United States | 08724 |
| 643 | Veterans Adminstration New Jersey Health Care System | East Orange | New Jersey | United States | 07018-1095 |
| 644 | Southern Ocean County Medical Center | Manahawkin | New Jersey | United States | 08050 |
| 645 | Morristown Medical Center | Morristown | New Jersey | United States | 07960 |
| 646 | Virtua Memorial | Mount Holly | New Jersey | United States | 08060 |
| 647 | Jersey Shore Medical Center | Neptune | New Jersey | United States | 07753 |
| 648 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 649 | Riverview Medical Center/Booker Cancer Center | Red Bank | New Jersey | United States | 07701 |
| 650 | Robert Wood Johnson University Hospital Somerset | Somerville | New Jersey | United States | 08876 |
| 651 | Overlook Hospital | Summit | New Jersey | United States | 07902 |
| 652 | Virtua Voorhees | Voorhees | New Jersey | United States | 08043 |
| 653 | Lovelace Medical Center-Downtown | Albuquerque | New Mexico | United States | 87102 |
| 654 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 655 | New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico | United States | 87109 |
| 656 | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico | United States | 88011 |
| 657 | New York Oncology Hematology PC -Albany Medical Center | Albany | New York | United States | 12208 |
| 658 | Montefiore Medical Center-Einstein Campus | Bronx | New York | United States | 10461 |
| 659 | Montefiore Medical Center-Weiler Hospital | Bronx | New York | United States | 10461 |
| 660 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467-2490 |
| 661 | State University of New York Downstate Medical Center | Brooklyn | New York | United States | 11203 |
| 662 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 663 | Mary Imogene Bassett Hospital | Cooperstown | New York | United States | 13326 |
| 664 | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York | United States | 14905 |
| 665 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 666 | Orange Regional Medical Center | Middletown | New York | United States | 10940 |
| 667 | North Shore-LIJ Health System/Center for Advanced Medicine | New Hyde Park | New York | United States | 11040 |
| 668 | Beth Israel Medical Center | New York | New York | United States | 10003 |
| 669 | Columbia University/Herbert Irving Cancer Center | New York | New York | United States | 10032 |
| 670 | Highland Hospital | Rochester | New York | United States | 14620 |
| 671 | University of Rochester | Rochester | New York | United States | 14642 |
| 672 | Stony Brook University Medical Center | Stony Brook | New York | United States | 11794 |
| 673 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 674 | Faxton-Saint Luke's Healthcare | Utica | New York | United States | 13502 |
| 675 | Randolph Hospital | Asheboro | North Carolina | United States | 27203 |
| 676 | Cancer Care of Western North Carolina | Asheville | North Carolina | United States | 28801 |
| 677 | Mission Hospital-Memorial Campus | Asheville | North Carolina | United States | 28801 |
| 678 | Asheville Hematology-Oncology Associates | Asheville | North Carolina | United States | 28803 |
| 679 | Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina | United States | 27215 |
| 680 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 681 | Oncology Specialists of Charlotte | Charlotte | North Carolina | United States | 28207 |
| 682 | Southern Oncology Specialists-Charlotte | Charlotte | North Carolina | United States | 28262 |
| 683 | Sampson Radiation Oncology | Clinton | North Carolina | United States | 28328 |
| 684 | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | United States | 28328 |
| 685 | Duke University Medical Center | Durham | North Carolina | United States | 27710 |
| 686 | Cape Fear Valley Health System | Fayetteville | North Carolina | United States | 28304 |
| 687 | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | United States | 27534 |
| 688 | Wayne Memorial Hospital | Goldsboro | North Carolina | United States | 27534 |
| 689 | Wayne Radiation Oncology | Goldsboro | North Carolina | United States | 27534 |
| 690 | Cone Health Cancer Center | Greensboro | North Carolina | United States | 27403 |
| 691 | Hendersonville Hematology and Oncology at Pardee | Hendersonville | North Carolina | United States | 28791 |
| 692 | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | United States | 28791 |
| 693 | Park Ridge Hospital Breast Health Center | Hendersonville | North Carolina | United States | 28792 |
| 694 | Hayworth Cancer Center | High Point | North Carolina | United States | 27262 |
| 695 | High Point Regional Hospital | High Point | North Carolina | United States | 27262 |
| 696 | Lake Norman Hematology Oncology Specialists-Huntersville | Huntersville | North Carolina | United States | 28078 |
| 697 | Southern Oncology Specialists-Huntersville | Huntersville | North Carolina | United States | 28078 |
| 698 | Onslow Memorial Hospital | Jacksonville | North Carolina | United States | 28546 |
| 699 | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | United States | 28546 |
| 700 | Kinston Medical Specialists PA | Kinston | North Carolina | United States | 28501 |
| 701 | Matthews Radiation Oncology Center | Matthews | North Carolina | United States | 28105 |
| 702 | Novant Health Cancer Specialists-Matthews | Matthews | North Carolina | United States | 28105 |
| 703 | Cone Heath Cancer Center at Mebane | Mebane | North Carolina | United States | 27302 |
| 704 | Lake Norman Hematology Oncology Specialists-Mooresville | Mooresville | North Carolina | United States | 28117 |
| 705 | FirstHealth of the Carolinas-Moore Regional Hosiptal | Pinehurst | North Carolina | United States | 28374 |
| 706 | Duke Raleigh Hospital | Raleigh | North Carolina | United States | 27609 |
| 707 | Annie Penn Memorial Hospital | Reidsville | North Carolina | United States | 27320 |
| 708 | Southeastern Medical Oncology Center-Wilson | Wilson | North Carolina | United States | 27893 |
| 709 | Southeast Clinical Oncology Research (SCOR) Consortium NCORP | Winston-Salem | North Carolina | United States | 27104 |
| 710 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 711 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 712 | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | United States | 58103 |
| 713 | Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 714 | Sanford Clinic North-Fargo | Fargo | North Dakota | United States | 58122 |
| 715 | Sanford Medical Center-Fargo | Fargo | North Dakota | United States | 58122 |
| 716 | Trinity Cancer Care Center | Minot | North Dakota | United States | 58701 |
| 717 | Cleveland Clinic Cancer Center Beachwood | Beachwood | Ohio | United States | 44122 |
| 718 | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | United States | 44122 |
| 719 | Strecker Cancer Center-Belpre | Belpre | Ohio | United States | 45714 |
| 720 | Mercy Medical Center | Canton | Ohio | United States | 44708 |
| 721 | Aultman Health Foundation | Canton | Ohio | United States | 44710 |
| 722 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 723 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 724 | Geaugra Hospital | Chardon | Ohio | United States | 44024 |
| 725 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 726 | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio | United States | 45202 |
| 727 | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio | United States | 45211 |
| 728 | University of Cincinnati/Barrett Cancer Center | Cincinnati | Ohio | United States | 45219 |
| 729 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 730 | Oncology Hematology Care Inc - Anderson | Cincinnati | Ohio | United States | 45230 |
| 731 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 732 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 733 | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio | United States | 45242 |
| 734 | TriHealth Cancer Institute-Westside | Cincinnati | Ohio | United States | 45247 |
| 735 | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio | United States | 45255 |
| 736 | Case Western Reserve University | Cleveland | Ohio | United States | 44106 |
| 737 | MetroHealth Medical Center | Cleveland | Ohio | United States | 44109 |
| 738 | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | United States | 44111 |
| 739 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 740 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 741 | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | United States | 43214 |
| 742 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 743 | Columbus NCI Community Oncology Research Program | Columbus | Ohio | United States | 43215 |
| 744 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 745 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 746 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 747 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 748 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 749 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 750 | Dayton Physicians LLC-Samaritan North | Dayton | Ohio | United States | 45415 |
| 751 | Samaritan North Health Center | Dayton | Ohio | United States | 45415 |
| 752 | Dayton NCI Community Oncology Research Program | Dayton | Ohio | United States | 45420 |
| 753 | Delaware Health Center-Grady Cancer Center | Delaware | Ohio | United States | 43015 |
| 754 | Delaware Radiation Oncology | Delaware | Ohio | United States | 43015 |
| 755 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 756 | Mercy Cancer Center-Elyria | Elyria | Ohio | United States | 44035 |
| 757 | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio | United States | 45014 |
| 758 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 759 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 760 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 761 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 762 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 763 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 764 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 765 | Cleveland Clinic Cancer Center Independence | Independence | Ohio | United States | 44131 |
| 766 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 767 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 768 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 769 | Lancaster Radiation Oncology | Lancaster | Ohio | United States | 43130 |
| 770 | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio | United States | 44906 |
| 771 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 772 | OneHealth Marion General Hospital | Marion | Ohio | United States | 43302 |
| 773 | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | United States | 44124 |
| 774 | Ireland Cancer Center Landerbrook Health Center | Mayfield Heights | Ohio | United States | 44124 |
| 775 | Lake University Ireland Cancer Center | Mentor | Ohio | United States | 44060 |
| 776 | Southwest General Health Center Ireland Cancer Center | Middleburg Heights | Ohio | United States | 44130 |
| 777 | Dayton Physicians LLC-Signal Point | Middletown | Ohio | United States | 45042 |
| 778 | Knox Community Hospital | Mount Vernon | Ohio | United States | 43050 |
| 779 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 780 | Newark Radiation Oncology | Newark | Ohio | United States | 43055 |
| 781 | Southern Ohio Medical Center | Portsmouth | Ohio | United States | 45662 |
| 782 | Ireland Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | United States | 44870 |
| 783 | North Coast Cancer Care | Sandusky | Ohio | United States | 44870 |
| 784 | Dayton Physicians LLC-Wilson | Sidney | Ohio | United States | 45365 |
| 785 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 786 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 787 | Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | United States | 44136 |
| 788 | Flower Hospital | Sylvania | Ohio | United States | 43560 |
| 789 | University of Toledo | Toledo | Ohio | United States | 43614 |
| 790 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 791 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 792 | University Hospitals Sharon Health Center | Wadsworth | Ohio | United States | 44281 |
| 793 | South Pointe Hospital | Warrensville Heights | Ohio | United States | 44122 |
| 794 | University Pointe | West Chester | Ohio | United States | 45069 |
| 795 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 796 | UH-Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio | United States | 44145 |
| 797 | UHHS-Westlake Medical Center | Westlake | Ohio | United States | 44145 |
| 798 | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | United States | 44691 |
| 799 | Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | United States | 45433-5529 |
| 800 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 801 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 802 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 803 | Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | United States | 74146 |
| 804 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 805 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 806 | Providence Oncology and Hematology Care Southeast | Clackamas | Oregon | United States | 97015 |
| 807 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 808 | Legacy Mount Hood Medical Center | Gresham | Oregon | United States | 97030 |
| 809 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 810 | Providence Willamette Falls Medical Center | Oregon City | Oregon | United States | 97045 |
| 811 | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | United States | 97210 |
| 812 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 813 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 814 | Kaiser Permanente Northwest | Portland | Oregon | United States | 97227 |
| 815 | Oregon Health and Science University | Portland | Oregon | United States | 97239 |
| 816 | Salem Hospital | Salem | Oregon | United States | 97301 |
| 817 | Legacy Meridian Park Hospital | Tualatin | Oregon | United States | 97062 |
| 818 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 819 | UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | United States | 15009 |
| 820 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 821 | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | United States | 19010 |
| 822 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 823 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 824 | Ephrata Cancer Center | Ephrata | Pennsylvania | United States | 17522 |
| 825 | Ephrata Community Hospital | Ephrata | Pennsylvania | United States | 17522 |
| 826 | Adams Cancer Center | Gettysburg | Pennsylvania | United States | 17325 |
| 827 | UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | United States | 15601 |
| 828 | Cherry Tree Cancer Center | Hanover | Pennsylvania | United States | 17331 |
| 829 | PinnacleHealth Cancer Center-Community Campus | Harrisburg | Pennsylvania | United States | 17109 |
| 830 | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 831 | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 832 | Jefferson Hospital | Jefferson Hills | Pennsylvania | United States | 15025 |
| 833 | UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | United States | 15901 |
| 834 | Armstrong Center for Medicine and Health | Kittanning | Pennsylvania | United States | 16201 |
| 835 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 836 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 837 | UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | United States | 15132 |
| 838 | Riddle Memorial Hospital | Media | Pennsylvania | United States | 19063 |
| 839 | Forbes Hospital | Monroeville | Pennsylvania | United States | 15146 |
| 840 | UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon | Pennsylvania | United States | 15108 |
| 841 | Allegheny Valley Hospital | Natrona Heights | Pennsylvania | United States | 15065 |
| 842 | Paoli Memorial Hospital | Paoli | Pennsylvania | United States | 19301 |
| 843 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 844 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 845 | Temple University Hospital | Philadelphia | Pennsylvania | United States | 19140 |
| 846 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212 |
| 847 | UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | United States | 15213 |
| 848 | UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania | United States | 15213 |
| 849 | UPMC-Saint Margaret | Pittsburgh | Pennsylvania | United States | 15215 |
| 850 | West Penn Hospital | Pittsburgh | Pennsylvania | United States | 15224 |
| 851 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
| 852 | UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | United States | 15232 |
| 853 | UPMC Jefferson Regional Radiation Oncology | Pittsburgh | Pennsylvania | United States | 15236 |
| 854 | UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | United States | 15237 |
| 855 | UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | United States | 15243 |
| 856 | Pottstown Memorial Medical Center | Pottstown | Pennsylvania | United States | 19464 |
| 857 | Geisinger Medical Oncology-Pottsville | Pottsville | Pennsylvania | United States | 17901 |
| 858 | Penn State Health Saint Joseph Medical Center | Reading | Pennsylvania | United States | 19605 |
| 859 | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania | United States | 18840 |
| 860 | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | United States | 17870 |
| 861 | UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | United States | 16346 |
| 862 | Geisinger Medical Group | State College | Pennsylvania | United States | 16801 |
| 863 | UPMC Uniontown Hospital Radiation Oncology | Uniontown | Pennsylvania | United States | 15401 |
| 864 | UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | United States | 15301 |
| 865 | Chester County Hospital | West Chester | Pennsylvania | United States | 19380 |
| 866 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 867 | Wexford Health and Wellness Pavilion | Wexford | Pennsylvania | United States | 15090 |
| 868 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 869 | Susquehanna Cancer Center | Williamsport | Pennsylvania | United States | 17701 |
| 870 | Lankenau Medical Center | Wynnewood | Pennsylvania | United States | 19096 |
| 871 | WellSpan Health-York Cancer Center | York | Pennsylvania | United States | 17403 |
| 872 | WellSpan Health-York Hospital | York | Pennsylvania | United States | 17403 |
| 873 | AnMed Health Cancer Center | Anderson | South Carolina | United States | 29621 |
| 874 | Roper Hospital | Charleston | South Carolina | United States | 29401 |
| 875 | Charleston Hematology Oncology Associates-Roper | Charleston | South Carolina | United States | 29403 |
| 876 | Lowcountry Hematology Oncology PA-North Charleston | Charleston | South Carolina | United States | 29406 |
| 877 | Bon Secours Saint Francis Hospital | Charleston | South Carolina | United States | 29414 |
| 878 | Charleston Hematology Oncology Associates PA-St. Francis | Charleston | South Carolina | United States | 29414 |
| 879 | Lowcountry Hematology Oncology PA-West Ashley | Charleston | South Carolina | United States | 29414 |
| 880 | Greenville Health System Cancer Institute-Easley | Easley | South Carolina | United States | 29640 |
| 881 | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | United States | 29341 |
| 882 | Georgetown Hospital System | Georgetown | South Carolina | United States | 29440 |
| 883 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 884 | Greenville Health System Cancer Institute-Andrews | Greenville | South Carolina | United States | 29605 |
| 885 | Greenville Health System Cancer Institute-Butternut | Greenville | South Carolina | United States | 29605 |
| 886 | Greenville Health System Cancer Institute-Faris | Greenville | South Carolina | United States | 29605 |
| 887 | Greenville Memorial Hospital | Greenville | South Carolina | United States | 29605 |
| 888 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
| 889 | Greenville Health System Cancer Institute-Eastside | Greenville | South Carolina | United States | 29615 |
| 890 | Gibbs Cancer Center-Pelham | Greer | South Carolina | United States | 29651 |
| 891 | Carolina Blood and Cancer Care Associates PA-Lancaster | Lancaster | South Carolina | United States | 29720 |
| 892 | Lowcountry Hematology Oncology PA-Mount Pleasant | Mount Pleasant | South Carolina | United States | 29464 |
| 893 | Greenville Health System Cancer Institute-Seneca | Seneca | South Carolina | United States | 29672 |
| 894 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 895 | Greenville Health System Cancer Institute-Spartanburg | Spartanburg | South Carolina | United States | 29307 |
| 896 | MGC Hematology Oncology-Union | Union | South Carolina | United States | 29379 |
| 897 | Lexington Medical Center | West Columbia | South Carolina | United States | 29169 |
| 898 | Avera Cancer Institute-Aberdeen | Aberdeen | South Dakota | United States | 57401 |
| 899 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 900 | Sanford Cancer Center-Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 901 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 902 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 903 | Boston Baskin Cancer Center-Bartlett | Bartlett | Tennessee | United States | 38133 |
| 904 | Memorial Hospital | Chattanooga | Tennessee | United States | 37404 |
| 905 | Cookeville Regional Medical Center | Cookeville | Tennessee | United States | 38501 |
| 906 | Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee | United States | 37067 |
| 907 | Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee | United States | 37343 |
| 908 | Thompson Cancer Survival Center | Knoxville | Tennessee | United States | 37916 |
| 909 | Thompson Cancer Survival Center - West | Knoxville | Tennessee | United States | 37932 |
| 910 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 911 | Baptist Memorial Hospital for Women | Memphis | Tennessee | United States | 38120 |
| 912 | Family Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 913 | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | United States | 37204 |
| 914 | Meharry Medical College | Nashville | Tennessee | United States | 37208 |
| 915 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 916 | Thompson Oncology Group-Oak Ridge | Oak Ridge | Tennessee | United States | 37830 |
| 917 | Memorial GYN Plus | Ooltewah | Tennessee | United States | 37363 |
| 918 | The Don and Sybil Harrington Cancer Center | Amarillo | Texas | United States | 79106 |
| 919 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 920 | Parkland Memorial Hospital | Dallas | Texas | United States | 75235 |
| 921 | Baylor University Medical Center | Dallas | Texas | United States | 75246 |
| 922 | Texas Oncology at Baylor Charles A Sammons Cancer Center | Dallas | Texas | United States | 75246 |
| 923 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 924 | Brooke Army Medical Center | Fort Sam Houston | Texas | United States | 78234 |
| 925 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0565 |
| 926 | Lyndon Baines Johnson General Hospital | Houston | Texas | United States | 77026-1967 |
| 927 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 928 | Ben Taub General Hospital | Houston | Texas | United States | 77030 |
| 929 | M D Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 930 | Memorial Hermann Texas Medical Center | Houston | Texas | United States | 77030 |
| 931 | Michael E DeBakey VA Medical Center | Houston | Texas | United States | 77030 |
| 932 | The Methodist Hospital System | Houston | Texas | United States | 77030 |
| 933 | MD Anderson Regional Care Center-Katy | Houston | Texas | United States | 77094 |
| 934 | UTMB Cancer Center at Victory Lakes | League City | Texas | United States | 77573 |
| 935 | Covenant Medical Center-Lakeside | Lubbock | Texas | United States | 79410 |
| 936 | Texas Tech University Health Sciences Center-Lubbock | Lubbock | Texas | United States | 79430 |
| 937 | MD Anderson Regional Care Center-Bay Area | Nassau Bay | Texas | United States | 77058 |
| 938 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 939 | MD Anderson Regional Care Center-Sugar Land | Sugar Land | Texas | United States | 77478 |
| 940 | MD Anderson Regional Care Center-The Woodlands | The Woodlands | Texas | United States | 77384 |
| 941 | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | United States | 84003 |
| 942 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 943 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 944 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 945 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 946 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 947 | Dixie Medical Center Regional Cancer Center | Saint George | Utah | United States | 84770 |
| 948 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 949 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 950 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 951 | South Jordan Health Center | South Jordan | Utah | United States | 84009 |
| 952 | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont | United States | 05602 |
| 953 | University of Vermont Medical Center | Burlington | Vermont | United States | 05401 |
| 954 | University of Vermont College of Medicine | Burlington | Vermont | United States | 05405 |
| 955 | University of Virginia Cancer Center | Charlottesville | Virginia | United States | 22908 |
| 956 | Hematology Oncology Associates of Fredericksburg Inc | Fredericksburg | Virginia | United States | 22408 |
| 957 | Lynchburg Hematology-Oncology Clinic | Lynchburg | Virginia | United States | 24501 |
| 958 | Memorial Hospital Of Martinsville | Martinsville | Virginia | United States | 24115 |
| 959 | Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia | United States | 23116 |
| 960 | Bon Secours Saint Francis Medical Center | Midlothian | Virginia | United States | 23114 |
| 961 | Bon Secours Saint Mary's Hospital | Richmond | Virginia | United States | 23226 |
| 962 | Virginia Cancer Institute | Richmond | Virginia | United States | 23230 |
| 963 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 964 | VCU Community Memorial Health Center | South Hill | Virginia | United States | 23970 |
| 965 | Shenandoah Oncology Associates PC | Winchester | Virginia | United States | 22601 |
| 966 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 967 | Cancer Care Center at Island Hospital | Anacortes | Washington | United States | 98221 |
| 968 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 969 | Virginia Mason Bainbridge Island Medical Center | Bainbridge Island | Washington | United States | 98110 |
| 970 | Overlake Hospital Medical Center | Bellevue | Washington | United States | 98004 |
| 971 | Swedish Cancer Institute-Eastside Oncology Hematology | Bellevue | Washington | United States | 98005 |
| 972 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 973 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 974 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 975 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
| 976 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 977 | Swedish Medical Center-Edmonds | Edmonds | Washington | United States | 98026 |
| 978 | Saint Elizabeth Hospital | Enumclaw | Washington | United States | 98022 |
| 979 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 980 | Virginia Mason Federal Way Medical Center | Federal Way | Washington | United States | 98002 |
| 981 | Saint Francis Hospital | Federal Way | Washington | United States | 98003 |
| 982 | Tacoma/Valley Radiation Oncology Centers-Gig Harbor | Gig Harbor | Washington | United States | 98332 |
| 983 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
| 984 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 985 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 986 | Northwest Cancer Clinic | Kennewick | Washington | United States | 99336 |
| 987 | Seattle Cancer Care Alliance at EvergreenHealth | Kirkland | Washington | United States | 98034 |
| 988 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 989 | Saint Clare Hospital | Lakewood | Washington | United States | 98499 |
| 990 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 991 | Virginia Mason Lynnwood Medical Center | Lynnwood | Washington | United States | 98036 |
| 992 | Skagit Valley Hospital Regional Cancer Care Center | Mount Vernon | Washington | United States | 98273 |
| 993 | Skagit Valley Hospital | Mount Vernon | Washington | United States | 98274 |
| 994 | Providence - Saint Peter Hospital | Olympia | Washington | United States | 98506-5166 |
| 995 | Capital Medical Center | Olympia | Washington | United States | 98507 |
| 996 | Jefferson Healthcare | Port Townsend | Washington | United States | 98368 |
| 997 | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | United States | 98370 |
| 998 | Peninsula Cancer Center | Poulsbo | Washington | United States | 98370 |
| 999 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 1000 | Tacoma/Valley Radiation Oncology Centers-Puyallup | Puyallup | Washington | United States | 98372 |
| 1001 | Virginia Mason Medical Center | Seattle | Washington | United States | 98101 |
| 1002 | Minor and James Medical PLLC | Seattle | Washington | United States | 98104 |
| 1003 | Pacific Gynecology Specialists | Seattle | Washington | United States | 98104 |
| 1004 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 1005 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109 |
| 1006 | Seattle Cancer Care Alliance | Seattle | Washington | United States | 98109 |
| 1007 | Group Health Cooperative-Seattle | Seattle | Washington | United States | 98112 |
| 1008 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 1009 | Seattle Cancer Care Alliance at Northwest Hospital | Seattle | Washington | United States | 98133 |
| 1010 | University of Washington Medical Center | Seattle | Washington | United States | 98195 |
| 1011 | Providence Regional Cancer System-Shelton | Shelton | Washington | United States | 98584 |
| 1012 | Rockwood Clinic Cancer Treatment Center-Valley | Spokane Valley | Washington | United States | 99216 |
| 1013 | Cancer Care Northwest - Spokane South | Spokane | Washington | United States | 99202 |
| 1014 | Rockwood Cancer Treatment Center-DHEC-Downtown | Spokane | Washington | United States | 99204 |
| 1015 | Spokane Valley Cancer Center-Mayfair | Spokane | Washington | United States | 99208 |
| 1016 | Cancer Care Northwest-Valley | Spokane | Washington | United States | 99216 |
| 1017 | Cancer Care Northwest-North Spokane | Spokane | Washington | United States | 99218 |
| 1018 | Rockwood North Cancer Treatment Center | Spokane | Washington | United States | 99218 |
| 1019 | Tacoma/Valley Radiation Oncology Centers-Jackson Hall | Tacoma | Washington | United States | 97405 |
| 1020 | Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington | United States | 98405 |
| 1021 | MultiCare Allenmore Hospital | Tacoma | Washington | United States | 98405 |
| 1022 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 1023 | Northwest Medical Specialties PLLC | Tacoma | Washington | United States | 98405 |
| 1024 | Northwest NCI Community Oncology Research Program | Tacoma | Washington | United States | 98405 |
| 1025 | Saint Joseph Medical Center | Tacoma | Washington | United States | 98405 |
| 1026 | Tacoma/Valley Radiation Oncology Centers-Saint Joe's | Tacoma | Washington | United States | 98405 |
| 1027 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 1028 | Compass Oncology Vancouver | Vancouver | Washington | United States | 98684 |
| 1029 | Legacy Salmon Creek Hospital | Vancouver | Washington | United States | 98686 |
| 1030 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 1031 | Wenatchee Valley Hospital and Clinics | Wenatchee | Washington | United States | 98801 |
| 1032 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 1033 | Providence Regional Cancer System-Yelm | Yelm | Washington | United States | 98597 |
| 1034 | United Hospital Center | Bridgeport | West Virginia | United States | 26330 |
| 1035 | West Virginia University Charleston | Charleston | West Virginia | United States | 25304 |
| 1036 | Saint Mary's Medical Center | Huntington | West Virginia | United States | 25702 |
| 1037 | WVUH-East City Hospital | Martinsburg | West Virginia | United States | 25401 |
| 1038 | West Virginia University Healthcare | Morgantown | West Virginia | United States | 26506 |
| 1039 | Camden-Clark Memorial Hospital | Parkersburg | West Virginia | United States | 26101 |
| 1040 | Langlade Hospital and Cancer Center | Antigo | Wisconsin | United States | 54409 |
| 1041 | Fox Valley Hematology and Oncology SC-Appleton | Appleton | Wisconsin | United States | 54913 |
| 1042 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 1043 | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin | United States | 54729 |
| 1044 | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin | United States | 54701 |
| 1045 | Sacred Heart Hospital | Eau Claire | Wisconsin | United States | 54701 |
| 1046 | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin | United States | 54937 |
| 1047 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 1048 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 1049 | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin | United States | 54301-3526 |
| 1050 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 1051 | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin | United States | 54303 |
| 1052 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 54303 |
| 1053 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 1054 | Mercy Health System | Janesville | Wisconsin | United States | 53547 |
| 1055 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 1056 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 1057 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 1058 | Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin | United States | 54848 |
| 1059 | University of Wisconsin Hospital and Clinics | Madison | Wisconsin | United States | 53792 |
| 1060 | Holy Family Memorial Hospital | Manitowoc | Wisconsin | United States | 54221 |
| 1061 | Bay Area Medical Center | Marinette | Wisconsin | United States | 54143 |
| 1062 | Vince Lombardi Cancer Clinic-Marinette | Marinette | Wisconsin | United States | 54143 |
| 1063 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449 |
| 1064 | Saint Joseph's Hospital | Marshfield | Wisconsin | United States | 54449 |
| 1065 | Community Memorial Hospital | Menomonee Falls | Wisconsin | United States | 53051 |
| 1066 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
| 1067 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 1068 | Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 1069 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 1070 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 1071 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 1072 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 1073 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 1074 | Green Bay Oncology - Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 1075 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 1076 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 1077 | Marshfield Clinic at James Beck Cancer Center | Rhinelander | Wisconsin | United States | 54501 |
| 1078 | Saint Mary's Hospital | Rhinelander | Wisconsin | United States | 54501 |
| 1079 | Lakeview Medical Center-Marshfield Clinic | Rice Lake | Wisconsin | United States | 54868 |
| 1080 | Marshfield Clinic-Rice Lake Center | Rice Lake | Wisconsin | United States | 54868 |
| 1081 | HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin | United States | 53081 |
| 1082 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 1083 | Marshfield Clinic Cancer Care at Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 1084 | Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 1085 | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235-1495 |
| 1086 | Green Bay Oncology - Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235 |
| 1087 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 1088 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 1089 | Aurora Cancer Care-Waukesha | Waukesha | Wisconsin | United States | 53188 |
| 1090 | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 1091 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
| 1092 | Aspirus Regional Cancer Center | Wausau | Wisconsin | United States | 54401 |
| 1093 | Marshfield Clinic-Wausau Center | Wausau | Wisconsin | United States | 54401 |
| 1094 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 1095 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 1096 | The Alyce and Elmore Kraemer Cancer Care Center | West Bend | Wisconsin | United States | 53095 |
| 1097 | Diagnostic and Treatment Center | Weston | Wisconsin | United States | 54476 |
| 1098 | Marshfield Clinic - Weston Center | Weston | Wisconsin | United States | 54476 |
| 1099 | Saint Clare's Hospital | Weston | Wisconsin | United States | 54476 |
| 1100 | Aspirus UW Cancer Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 1101 | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 1102 | Rocky Mountain Oncology | Casper | Wyoming | United States | 82609 |
| 1103 | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | United States | 82001 |
| 1104 | Big Horn Basin Cancer Center | Cody | Wyoming | United States | 82414 |
| 1105 | Billings Clinic-Cody | Cody | Wyoming | United States | 82414 |
| 1106 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
| 1107 | Juravinski Cancer Centre at Hamilton Health Sciences | Hamilton | Ontario | Canada | L8V 5C2 |
| 1108 | Ottawa Hospital and Cancer Center-General Campus | Ottawa | Ontario | Canada | K1H 8L6 |
| 1109 | University Health Network-Princess Margaret Hospital | Toronto | Ontario | Canada | M5G 2M9 |
| 1110 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 1111 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
Sponsors and Collaborators
- Southwest Oncology Group
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Vassiliki Papadimitrakopoulou, Southwest Oncology Group
Study Documents (Full-Text)
More Information
Publications
None provided.Responsible Party:
Southwest Oncology Group
ClinicalTrials.gov Identifier:
NCT02785913
Other Study ID Numbers:
- S1400B
- NCI-2014-01379
First Posted:
May 30, 2016
Last Update Posted:
Oct 23, 2020
Last Verified:
Sep 1, 2020
Study Results
Participant Flow
| Recruitment Details | |
|---|---|
| Pre-assignment Detail | 31 participants were enrolled. However, 4 were deemed ineligible and 1 died prior to receiving study treatment. Thus 26 participants were eligible. Of these, 21 were PI3K GNE-positive (had at least one mutation that was possibly associated with clinical benefit of PI3K inhibitors), and were included in the primary analysis population (PAP). |
| Arm/Group Title | Arm I (GDC-0032) |
|---|---|
| Arm/Group Description | Participants receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Taselisib: Given PO |
| Period Title: Overall Study | |
| STARTED | 26 |
| COMPLETED | 0 |
| NOT COMPLETED | 26 |
Baseline Characteristics
| Arm/Group Title | Arm I (GDC-0032) |
|---|---|
| Arm/Group Description | Patients receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Taselisib: Given PO |
| Overall Participants | 26 |
| Age (years) [Median (Full Range) ] | |
| Median (Full Range) [years] |
68.1
|
| Sex: Female, Male (Count of Participants) | |
| Female |
7
26.9%
|
| Male |
19
73.1%
|
| Ethnicity (NIH/OMB) (Count of Participants) | |
| Hispanic or Latino |
1
3.8%
|
| Not Hispanic or Latino |
25
96.2%
|
| Unknown or Not Reported |
0
0%
|
| Race (NIH/OMB) (Count of Participants) | |
| American Indian or Alaska Native |
1
3.8%
|
| Asian |
1
3.8%
|
| Native Hawaiian or Other Pacific Islander |
0
0%
|
| Black or African American |
4
15.4%
|
| White |
19
73.1%
|
| More than one race |
0
0%
|
| Unknown or Not Reported |
1
3.8%
|
| PI3K GNE-Positive (Count of Participants) | |
| Count of Participants [Participants] |
21
80.8%
|
| Performance Status (Count of Participants) | |
| 0 |
7
26.9%
|
| 1 |
18
69.2%
|
| 2 |
1
3.8%
|
| Smoking History (Count of Participants) | |
| Current Smoker |
8
30.8%
|
| Former Smoker |
17
65.4%
|
| Never Smoker |
1
3.8%
|
Outcome Measures
| Title | Objective Response Rate (ORR) for PI3K GNE-positive Participants Registered to S1400B Treated With GDC-0032. |
|---|---|
| Description | ORR-the percentage of PI3K GNE-positive participants with confirmed and unconfirmed, partial response and complete response to treatment with GDC-0032 per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). |
| Time Frame | From date of registration to maximum of 3 years. |
Outcome Measure Data
| Analysis Population Description |
|---|
| PI3K GNE-positive participants only. |
| Arm/Group Title | Arm I (GDC-0032) |
|---|---|
| Arm/Group Description | Participants receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Taselisib: Given PO |
| Measure Participants | 21 |
| Confirmed Partial Response |
1
3.8%
|
| Stable/No Response |
13
50%
|
| Progression |
5
19.2%
|
| Early Death |
1
3.8%
|
| Assessment Inadequate |
1
3.8%
|
| Title | Investigator-assessed Progression Free Survival (IA-PFS) in Both the Subset of Participants Defined to be PI3K GNE-positive and in the Entire S1400B (PI3K FMI Positive) Study Population Treated With GDC-0032. |
|---|---|
| Description | From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause. |
| Time Frame | From time of registration to maximum of 3 years. |
Outcome Measure Data
| Analysis Population Description |
|---|
| PI3K GNE-positive subset (21 participants) and full eligible population (26 participants) |
| Arm/Group Title | Arm I (GDC-0032) |
|---|---|
| Arm/Group Description | Participants receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Taselisib: Given PO |
| Measure Participants | 26 |
| PI3K GNE-positive subset |
2.9
|
| Full eligible population |
2.7
|
| Title | Investigator-assessed Overall Survival (OS) in Both the Subset of Participants Defined to be PI3K GNE-positive and in the Entire S1400B (PI3K FMI Positive) Study Population Treated With GDC-0032. |
|---|---|
| Description | From date of sub-study registration to date of death due to any cause assessed by local review. |
| Time Frame | From time of registration to maximum of 3 years. |
Outcome Measure Data
| Analysis Population Description |
|---|
| PI3K GNE-positive subset (21 participants) and full eligible population (26 participants) |
| Arm/Group Title | Arm I (GDC-0032) |
|---|---|
| Arm/Group Description | Participants receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Taselisib: Given PO |
| Measure Participants | 26 |
| PI3K GNE-positive subset |
5.9
|
| Full eligible population |
5.9
|
| Title | ORR in the Entire S1400B (PI3K FMI Positive) Study Population Treated With GDC-0032. |
|---|---|
| Description | Per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). |
| Time Frame | From time of registration to maximum of 3 years. |
Outcome Measure Data
| Analysis Population Description |
|---|
| Eligible participants that received protocol treatment. |
| Arm/Group Title | Arm I (GDC-0032) |
|---|---|
| Arm/Group Description | Patients receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Taselisib: Given PO |
| Measure Participants | 26 |
| Confirmed Partial Response |
1
3.8%
|
| Stable/No Response |
16
61.5%
|
| Progression |
7
26.9%
|
| Early Death |
1
3.8%
|
| Assessment Inadequate |
1
3.8%
|
| Title | Duration of Response (DoR) Both in the Entire S1400B PI3K FMI Positive Study Population and in GNE Positive Participants Treated With GDC-0032 Who Achieve a CR or PR (Confirmed and Unconfirmed) by RECIST 1.1. |
|---|---|
| Description | Among participants who had a response, duration is calculated from registration to response date. |
| Time Frame | From time of registration to maximum of 3 years. |
Outcome Measure Data
| Analysis Population Description |
|---|
| This study only had one responder. |
| Arm/Group Title | Arm I (GDC-0032) |
|---|---|
| Arm/Group Description | Participants receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Taselisib: Given PO |
| Measure Participants | 1 |
| Number [months] |
4.4
|
| Title | Frequency and Severity of Toxicities Associated With GDC-0032. (Phase II) |
|---|---|
| Description | Frequency and severity of toxicities greater than Grade 2 associated with GDC-0032. |
| Time Frame | From date of registration to maximum of 3 years. |
Outcome Measure Data
| Analysis Population Description |
|---|
| Eligible participants that received protocol treatment and had greater than grade 2 toxicity. |
| Arm/Group Title | Arm I (GDC-0032) |
|---|---|
| Arm/Group Description | Participants receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Taselisib: Given PO |
| Measure Participants | 26 |
| Cardiac arrest |
1
3.8%
|
| Dehydration |
1
3.8%
|
| Diarrhea |
5
19.2%
|
| Dyspnea |
3
11.5%
|
| Fatigue |
3
11.5%
|
| Hyperglycemia |
5
19.2%
|
| Hypertension |
1
3.8%
|
| Hyponatremia |
1
3.8%
|
| Hypoxia |
1
3.8%
|
| Lung infection |
1
3.8%
|
| Lymphocyte count decreased |
3
11.5%
|
| Nausea |
1
3.8%
|
| Platelet count decreased |
1
3.8%
|
| Pneumonitis |
2
7.7%
|
| Pneumothorax |
1
3.8%
|
| Rash maculo-papular |
1
3.8%
|
| Respiratory failure |
1
3.8%
|
| Vomiting |
1
3.8%
|
Adverse Events
| Time Frame | From date of registration to maximum of 3 years. | |
|---|---|---|
| Adverse Event Reporting Description | ||
| Arm/Group Title | GDC-0032 | |
| Arm/Group Description | GDC-0032 | |
All Cause Mortality |
||
| GDC-0032 | ||
| Affected / at Risk (%) | # Events | |
| Total | 23/26 (88.5%) | |
Serious Adverse Events |
||
| GDC-0032 | ||
| Affected / at Risk (%) | # Events | |
| Total | 15/26 (57.7%) | |
| Blood and lymphatic system disorders | ||
| Anemia | 3/26 (11.5%) | |
| Cardiac disorders | ||
| Atrial fibrillation | 1/26 (3.8%) | |
| Atrial flutter | 1/26 (3.8%) | |
| Cardiac arrest | 2/26 (7.7%) | |
| Sinus bradycardia | 1/26 (3.8%) | |
| Gastrointestinal disorders | ||
| Abdominal pain | 1/26 (3.8%) | |
| Diarrhea | 4/26 (15.4%) | |
| Nausea | 1/26 (3.8%) | |
| Vomiting | 1/26 (3.8%) | |
| General disorders | ||
| Fatigue | 3/26 (11.5%) | |
| Fever | 1/26 (3.8%) | |
| Non-cardiac chest pain | 1/26 (3.8%) | |
| Pain | 1/26 (3.8%) | |
| Infections and infestations | ||
| Kidney infection | 1/26 (3.8%) | |
| Lung infection | 2/26 (7.7%) | |
| Sepsis | 2/26 (7.7%) | |
| Wound infection | 1/26 (3.8%) | |
| Investigations | ||
| Blood bilirubin increased | 1/26 (3.8%) | |
| Lymphocyte count decreased | 1/26 (3.8%) | |
| Metabolism and nutrition disorders | ||
| Dehydration | 2/26 (7.7%) | |
| Hypercalcemia | 1/26 (3.8%) | |
| Hyperglycemia | 3/26 (11.5%) | |
| Hypoalbuminemia | 1/26 (3.8%) | |
| Hypocalcemia | 1/26 (3.8%) | |
| Hyponatremia | 2/26 (7.7%) | |
| Metabolism and nutrition disorders - Other, specify | 1/26 (3.8%) | |
| Musculoskeletal and connective tissue disorders | ||
| Pain in extremity | 1/26 (3.8%) | |
| Neoplasms benign, malignant and unspecified (incl cysts and polyps) | ||
| Neoplasms benign, malignant and unspecified - Other | 1/26 (3.8%) | |
| Nervous system disorders | ||
| Nervous system disorders-Other | 1/26 (3.8%) | |
| Psychiatric disorders | ||
| Agitation | 1/26 (3.8%) | |
| Hallucinations | 1/26 (3.8%) | |
| Psychosis | 1/26 (3.8%) | |
| Renal and urinary disorders | ||
| Hematuria | 1/26 (3.8%) | |
| Respiratory, thoracic and mediastinal disorders | ||
| Dyspnea | 5/26 (19.2%) | |
| Hypoxia | 1/26 (3.8%) | |
| Pleural effusion | 3/26 (11.5%) | |
| Pneumonitis | 2/26 (7.7%) | |
| Pneumothorax | 1/26 (3.8%) | |
| Respiratory failure | 1/26 (3.8%) | |
| Skin and subcutaneous tissue disorders | ||
| Skin ulceration | 1/26 (3.8%) | |
| Vascular disorders | ||
| Superior vena cava syndrome | 1/26 (3.8%) | |
Other (Not Including Serious) Adverse Events |
||
| GDC-0032 | ||
| Affected / at Risk (%) | # Events | |
| Total | 25/26 (96.2%) | |
| Blood and lymphatic system disorders | ||
| Anemia | 9/26 (34.6%) | |
| Cardiac disorders | ||
| Sinus tachycardia | 2/26 (7.7%) | |
| Gastrointestinal disorders | ||
| Abdominal pain | 3/26 (11.5%) | |
| Constipation | 3/26 (11.5%) | |
| Diarrhea | 16/26 (61.5%) | |
| Mucositis oral | 2/26 (7.7%) | |
| Nausea | 10/26 (38.5%) | |
| Oral pain | 2/26 (7.7%) | |
| Vomiting | 4/26 (15.4%) | |
| General disorders | ||
| Chills | 3/26 (11.5%) | |
| Edema limbs | 7/26 (26.9%) | |
| Fatigue | 16/26 (61.5%) | |
| Fever | 4/26 (15.4%) | |
| Non-cardiac chest pain | 2/26 (7.7%) | |
| Infections and infestations | ||
| Lung infection | 2/26 (7.7%) | |
| Investigations | ||
| Alanine aminotransferase increased | 3/26 (11.5%) | |
| Alkaline phosphatase increased | 6/26 (23.1%) | |
| Aspartate aminotransferase increased | 2/26 (7.7%) | |
| Creatinine increased | 8/26 (30.8%) | |
| Investigations-Other | 3/26 (11.5%) | |
| Lipase increased | 4/26 (15.4%) | |
| Lymphocyte count decreased | 9/26 (34.6%) | |
| Platelet count decreased | 4/26 (15.4%) | |
| Serum amylase increased | 2/26 (7.7%) | |
| Weight loss | 11/26 (42.3%) | |
| Metabolism and nutrition disorders | ||
| Anorexia | 15/26 (57.7%) | |
| Dehydration | 2/26 (7.7%) | |
| Hyperglycemia | 19/26 (73.1%) | |
| Hypoalbuminemia | 8/26 (30.8%) | |
| Hypocalcemia | 7/26 (26.9%) | |
| Hypokalemia | 7/26 (26.9%) | |
| Hypomagnesemia | 3/26 (11.5%) | |
| Hyponatremia | 11/26 (42.3%) | |
| Metabolism and nutrition disorders - Other, specify | 2/26 (7.7%) | |
| Musculoskeletal and connective tissue disorders | ||
| Arthralgia | 3/26 (11.5%) | |
| Flank pain | 2/26 (7.7%) | |
| Generalized muscle weakness | 4/26 (15.4%) | |
| Myalgia | 3/26 (11.5%) | |
| Nervous system disorders | ||
| Dizziness | 3/26 (11.5%) | |
| Headache | 2/26 (7.7%) | |
| Peripheral sensory neuropathy | 2/26 (7.7%) | |
| Psychiatric disorders | ||
| Depression | 2/26 (7.7%) | |
| Insomnia | 2/26 (7.7%) | |
| Respiratory, thoracic and mediastinal disorders | ||
| Cough | 10/26 (38.5%) | |
| Dyspnea | 10/26 (38.5%) | |
| Productive cough | 4/26 (15.4%) | |
| Sore throat | 2/26 (7.7%) | |
| Skin and subcutaneous tissue disorders | ||
| Rash maculo-papular | 2/26 (7.7%) | |
| Vascular disorders | ||
| Hypertension | 4/26 (15.4%) | |
Limitations/Caveats
[Not Specified]
More Information
Certain Agreements
Principal Investigators are NOT employed by the organization sponsoring the study.
There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.
Results Point of Contact
| Name/Title | Lung Committee Statistician |
|---|---|
| Organization | SWOG Statistics and Data Management Center |
| Phone | 2066674623 |
| kmini@fredhutch.org |
Responsible Party:
Southwest Oncology Group
ClinicalTrials.gov Identifier:
NCT02785913
Other Study ID Numbers:
- S1400B
- NCI-2014-01379
First Posted:
May 30, 2016
Last Update Posted:
Oct 23, 2020
Last Verified:
Sep 1, 2020