Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic Shock
Study Details
Study Description
Brief Summary
The aim of this study is to find the utility of red cell distribution width and lactate/albumin ratio as prognostic markers in sepsis and septic shock patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Several indicators are being used to predict the prognosis of sepsis. Commonly used prognostic indicators include Acute Physiological and chronic health evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), Mortality in Emergency Department Score (MEDS), New York Sepsis severity score.
Red cell distribution Width and lactate albumin ratio are being investigated for there prognostic value in septic patients.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Non survivors group At 28 day, patients were divided into Non survivors group and Survivors group. |
Diagnostic Test: Red cell distribution width
Blood will be drawn from the peripheral vein, arterial or a central catheter. This procedure will be done at diagnosis, 3 ,7, 14 and 21 days of sepsis
Diagnostic Test: lactate albumin ratio measurement
Blood will be drawn from the peripheral vein, arterial or a central catheter. This procedure will be done at diagnosis, 3 ,7, 14 and 21 days of sepsis
|
| Survivors group At 28 day, patients were divided into Non survivors group and Survivors group. |
Diagnostic Test: Red cell distribution width
Blood will be drawn from the peripheral vein, arterial or a central catheter. This procedure will be done at diagnosis, 3 ,7, 14 and 21 days of sepsis
Diagnostic Test: lactate albumin ratio measurement
Blood will be drawn from the peripheral vein, arterial or a central catheter. This procedure will be done at diagnosis, 3 ,7, 14 and 21 days of sepsis
|
Outcome Measures
Primary Outcome Measures
- The prediction of mortality [28 days]
The diagnostic accuracy for prediction of 28th day mortality by Red cell distribution Width and lactate albumin ratio.
Secondary Outcome Measures
- Length of intensive care stay [28 days or till discharge from intensive care.]
Length of intensive care stay from admission till discharge either to the ward or mortality.
- Extent of organ dysfunctions in patients with severe sepsis and septic shock [28 days]
Organ dysfunction can be confirmed by acute change in sepsis-related organ failure assessment (SOFA).
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age from 18 to 60 years old.
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Clinical criteria of sepsis
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Or clinical criteria of septic shock including sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure > 65 mmHg and having a serum lactate level > 2 mmol/L despite adequate volume resuscitation.
Exclusion Criteria:
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No informed consent.
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Patient with incomplete information and data.
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The patient who received blood transfusion within 90 days before emergency admission.
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The patients who are known to have long-term conditions causing anemia like sickle cell anemia, thalassemia, iron deficiency anemia.
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Malignancy and chemotherapy during the previous 90 days.
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Patients with either hepatic dysfunction, renal failure, having any disease in which albumin should be supplemented as liver cirrhosis with ascites, nephrotic syndrome and burns.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Tanta University Hospitals | Tanta | Elgharbia | Egypt | 31527 |
Sponsors and Collaborators
- Tanta University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 34640/4/12