Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy Elderly

• Sponsor: Umeå University (Other)
• Overall Status: Completed
• CT.gov ID: NCT01188382
• Collaborator: (none)
• Enrollment: 40
• Location: 1
• Duration (Months): 16
• Patients Per Site Per Month: 2.5

Study Details

Study Description

Brief Summary

Objective. The intracranial pressure and cerebrospinal outflow resistance are essential parameters to describe the cerebrospinal fluid dynamic system. Outflow resistance effects intracranial pressure, pulse amplitudes, cerebrospinal fluid absorption as well as the compliance of the system. The objective of this study was to determine the reference values in the elderly.

Methods. Elderly people (60-82 years), considering themselves healthy, were recruited through an ad in the local paper. All were evaluated with a 3 Tesla magnetic resonance imaging apparatus. Subjects were eligible if they did not have any psychiatric or neurological disorder or signs of advanced atherosclerotic disease. Intracranial pressure and outflow resistance were determined by a constant pressure infusion method with the patient in the supine position. The study population consisted of 40 subjects (mean age 70 years; 23 women).

Condition or Disease	Intervention/Treatment	Phase
Healthy Elderly	Procedure: CSF dynamic investigation

Study Design

• Study Type: Observational
• Actual Enrollment: 40 participants
• Observational Model: Case-Only
• Time Perspective: Prospective
• Official Title: Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy Elderly
• Study Start Date: Aug 1, 2007
• Actual Primary Completion Date: Dec 1, 2008
• Actual Study Completion Date: Dec 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
Healthy elderly Healthy elderly 60-82 years; Normal MRI; No psychiatric or neurological disorder and without signs of advanced atherosclerotic disease	Procedure: CSF dynamic investigation

Outcome Measures

Primary Outcome Measures

1. CSF outflow resistance []

Secondary Outcome Measures

1. Intracranial pressure []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 60 Years to 82 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Healthy

• 60-82 years

Exclusion Criteria:

• Psychiatric or neurological disorder or advanced atherosclerotic disease

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Dep Clincial Neuroscience, Umeå university	Umeå		Sweden	901 85

Sponsors and Collaborators

• Umeå University

Investigators

• Principal Investigator: Jan I Malm, PhD, MD, Umeå University

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

• Web site of the Umeå hydrocephalus research group

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT01188382
• Other Study ID Numbers: Hydrocephalus100
• First Posted: Aug 25, 2010
• Last Update Posted: Aug 25, 2010
• Last Verified: Jun 1, 2010

• Keywords provided by , ,: Intracranial pressure; resistance; CSF outflow; elderly; reference value

Study Results

No Results Posted as of Aug 25, 2010