DREM: Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction

Sponsor

Centre d'Investigation Clinique et Technologique 805 (Other)

Overall Status

Unknown status

CT.gov ID

NCT01569217

Collaborator

(none)

200

Enrollment

Location

Duration (Months)

2.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this study is to better discriminate respiratory muscle dysfunction by comparing the measurements of thoracoabdominal motion obtained by an optoelectronic recording and the conventional tests of respiratory muscle strength. The final objective is to better select in the future the patients who need more specific assessment of diaphragmatic function like "maximal transdiaphragmatic pressure" measurement and "phrenic nerve stimulation".

Condition or Disease	Intervention/Treatment	Phase
Respiratory Failure Neuromuscular Disorder Diaphragmatic Paralysis

Detailed Description

All patients which had suspected respiratory muscle dysfunction will have usual exploration of the respiratory muscles according to the clinician prescription. These explorations can include :

Lung volumes in seating and supine position
Maximal inspiratory and expiratory pressures
Maximal sniff pressures

And when diaphragmatic dysfunction is suspected :

Maximal transdiaphragmatic pressure
Phrenic nerve conduction

These patients will also beneficiate to the determination of volume variations of the upper rib cage, the lower rib cage and the abdominal compartments by using Opto-electronic plethysmography.

Study Design

Study Type:

Observational

Anticipated Enrollment :

200 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Construction of a Database to Identify Early Indicators of Respiratory Muscle Dysfunction in Neuromuscular Patients From the Optoelectronic Plethysmography Assessment of the Thoracoabdominal Motion

Study Start Date :

Jun 1, 2011

Anticipated Primary Completion Date :

Jun 1, 2018

Anticipated Study Completion Date :

Jul 1, 2018

Arms and Interventions

Arm	Intervention/Treatment
respiratory muscle dysfunction patients Neuromuscular patients
diaphragmatic dysfunction patients who present orthopnea, recruitment of accessory muscles, abdominal paradox, respiratory dysfunction or dyssynchronous movement

Outcome Measures

Primary Outcome Measures

compartmental distribution of the inspired/expired volumes [1 hour]
Measurements of the thoraco-abdominal motion and of the global lung volume changes. Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and for each compartiment (upper thorax, lower thorax, abdomen) contribution of these volumes will be expressed in percentage.

Secondary Outcome Measures

left side and right side contribution to the inspired/expired volumes [1 hour]
Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and each side contribution of these volumes will be expressed in percentage.