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A Registered Cohort Study on Brain Calcification

Sponsor
Wan-Jin Chen (Other)
Overall Status
Recruiting
CT.gov ID
NCT04010201
Collaborator
Taipei Veterans General Hospital, Taiwan (Other), Chang Gung Memorial Hospital (Other)
2,000
Enrollment
1
Location
724.2
Anticipated Duration (Months)
2.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Brain calcification is a common neuroimaging feature in patients with metabolic, neurological, or developmental disorders, infectious diseases, traumatic or toxic history, as well as in otherwise normal older people. To understand the clinical and genetic characteristics of brain calcification, we establish a cohort of brain calcification to follow up patients with brain calcification.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    2000 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    A Registered Cohort Study on Brain Calcification
    Actual Study Start Date :
    Aug 25, 2019
    Anticipated Primary Completion Date :
    Dec 31, 2029
    Anticipated Study Completion Date :
    Dec 31, 2079

    Outcome Measures

    Primary Outcome Measures

    1. The incidence of hereditary brain calcification [Up to 20 years]

      Look for the causative gene in the patient with brian calcification

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Patients with brain calcium deposit(s) based on examinations of CT scans

    • Patients with total calcification score(TCS) greater than the physiological threshold

    • Relatives of brain calcification patients.

    • Unrelated healthy controls

    • Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process

    Exclusion Criteria:

    • Brain calcification caused by specific secondary factors such as infection, poisoning, and trauma

    • Participants declining or unable to comply with trial procedures and visit schedule

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Department of Neurology, First Affiliated Hospital Fujian Medical University Fuzhou Fujian China 350005

    Sponsors and Collaborators

    • Wan-Jin Chen
    • Taipei Veterans General Hospital, Taiwan
    • Chang Gung Memorial Hospital

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Wan-Jin Chen, The Vice-Director for the Department of Neurology, First Affiliated Hospital of Fujian Medical University
    ClinicalTrials.gov Identifier:
    NCT04010201
    Other Study ID Numbers:
    • MRCTA,ECFAH of FMU [2019]198
    First Posted:
    Jul 8, 2019
    Last Update Posted:
    Sep 23, 2019
    Last Verified:
    Sep 1, 2019
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Wan-Jin Chen, The Vice-Director for the Department of Neurology, First Affiliated Hospital of Fujian Medical University
    brain calcification
    natural history
    genetics
    Additional relevant MeSH terms:
    Calcinosis

    Study Results

    No Results Posted as of Sep 23, 2019