RESCUE-SCD: REgiStry in Chinese yoUng pEople With Sudden Cardiac Death
Study Details
Study Description
Brief Summary
The number of sudden cardiac death is up to 540,000 every year in China. Inherited cardiovascular disease is a common cause of sudden cardiac death in young people, and diseases often have the characteristics of family aggregation, so it has a huge psychological and economic burden on family members. Studying the etiology of sudden cardiac death from the molecular level under the model of precision medicine is helpful for screening patients and their relatives so as to further diagnosis, treatment and management, which has important clinical and social significance.
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Detailed Description
In this study, sudden cardiac death and high risk of sudden cardiac death in patients younger than 40 years of age are recruited prospectively after informed consent was given. The investigator will collect the baseline clinical characteristics of the patients at enrollment, including comprehensive physical examination, laboratory testing of blood and urine, electrocardiography, 24-hour Holter, echocardiography, MRI and other examinations if necessary. The specimens retained include blood or oral swabs for all patients, and myocardium for patients receiving autopsy. Genetic testing will be performed to identify carried disease genes, genetic risk factors and potential therapy targets.
Study Design
Outcome Measures
Primary Outcome Measures
- number of participants with cardiovascular deaths [an average of 2 years]
including sudden cardiac death and deaths due to heart failure and stroke
Secondary Outcome Measures
- number of participants with heart failure [an average of 2 years]
progress to level III or IV in New York Heart Association class
- number of participants with stroke [an average of 2 years]
including cerebral infraction and hemorrhage
- number of participants with myocardial infarction [an average of 2 years]
including ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients with sudden cardiac death and sudden unexplained death diagnosed according current practice guidelines.
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Patients at high risk for sudden cardiac death. (1) Family history of sudden cardiac death at a young age; （2）Successful resuscitation from cardiac arrest; （3) Implantable cardioverter defibrillator implantation after a comprehensive clinical assessment of high risk of sudden cardiac death.
Exclusion Criteria:
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Patients who refuse to sign the informed consent or decline follow-up.
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Patients with sudden death due to car accidents, electric shocks, drowning, fighting, carbon monoxide poisoning and other external causes.
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Patients with sudden death due to other definite causes, such as cerebrovascular accident, severe kidney disease, respiratory disease, neurological disease, etc.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fuwai hospital | Beijing | Beijing | China | 100037 |
Sponsors and Collaborators
- China National Center for Cardiovascular Diseases
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RESCUE-SCD