BHC-C: Registry of Multicenter Brain-Heart Comorbidity in China

Sponsor

Beijing Tiantan Hospital (Other)

Overall Status

Recruiting

CT.gov ID

NCT05961748

Collaborator

(none)

100,000

Enrollment

Locations

252

Anticipated Duration (Months)

7142.9

Patients Per Site

28.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program. To establish a domestic multi-center, large-scale "brain-heart comorbidity" dynamic database platform including clinical, sample database, image and other multi-dimensional information requirements, through the construction of a multi-center intelligent scientific research integration platform based on artificial intelligence.

Any of newly diagnosed cardiovascular related diseases were identified via ICD-10-CM codes:

I21, I22, I24 (Ischaemic heart diseases) [i.e., ACS], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels).

The data is stored on the brain-heart comorbidity warehouse via a physical server at the institution's data centre or a virtual hosted appliance. The brain-heart comorbidity platform comprises of a series of these appliances connected into a multicenter network. This network can broadcast queries to each appliance. Results are subsequently collected and aggregated. Once the data is sent to the network, it is mapped to a standard and controlled set of clinical terminologies and undergoes a data quality assessment including 'data cleaning' that rejects records which do not meet the brain-heart comorbidity quality standards. The brain-heart comorbidity warehouse performs internal and extensive data quality assessment with every refresh based on conformance, completeness, and plausibility (http://10.100.101.65:30080/login).

Condition or Disease	Intervention/Treatment	Phase
Ischemic Heart Disease Cardiac Arrest Atrial Fibrillation Heart Failure Aortic Diseases Subarachnoid Hemorrhage Intracerebral Hemorrhage Cerebral Infarction Occlusion and Stenosis of Precerebral Arteries Occlusion and Stenosis of Cerebellar Arteries Cerebral Aneurysm Moyamoya Disease Arteriovenous Malformation of Cerebral Vessels	Other: Multi-disciplinary assessment

Study Design

Study Type:

Observational

Anticipated Enrollment :

100000 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Registry of Multicenter Brain-Heart Comorbidity in China

Actual Study Start Date :

Jan 1, 2012

Anticipated Primary Completion Date :

Dec 31, 2032

Anticipated Study Completion Date :

Dec 31, 2032

Outcome Measures

Primary Outcome Measures

Rate of Participants with Composite of All-Cause Mortality and Cardiovascular Outcomes [At discharge/30 days]
The occurrence of all-cause mortality, coronary artery disease event, stroke (ischemic or hemorrhagic), heart failure, or atrial fibrillation etc.
All-Cause Mortality [At discharge/30 days]
The occurrence of death
Rate of Participants with Composite of Cardiovascular Outcomes [At discharge/30 days]
The occurrence of coronary artery disease event, stroke (ischemic or hemorrhagic), heart failure, or atrial fibrillation etc.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Inclusion Criteria:

age > 18 years old
Any of newly diagnosed cardiovascular-related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) [i.e., ACS], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels).

Exclusion Criteria:

·refuse to participate in the registry

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Beijing Tiantan Hospital, Capital Medical University	Beijing	Beijing	China	100070
2	Beijing Anzhen Hospital, Capital Medical University	Beijing	Beijing	China
3	Beijing Chaoyang Hospital, Capital Medical University	Beijing	Beijing	China
4	Chinese People's Liberation Army (PLA) General Hospital	Beijing	Beijing	China
5	Peking University First Hospital	Beijing	Beijing	China
6	Xuanwu Hospital, Capital Medical University	Beijing	Beijing	China
7	The First Affiliated Hospital of Fujian Medical University	Fuzhou	Fujian	China
8	The First Affiliated Hospital of Xiamen University	Xiamen	Fujian	China
9	Shenzhen Qianhai Shekou Free Trade Zone Hospital	Shenzhen	Guangdong	China
10	The First Affiliated Hospital of Harbin Medical University	Harbin	Heilongjiang	China
11	The First Affiliated Hospital of Zhengzhou University	Zhengzhou	Henan	China
12	Huashan Hospital of Fudan University	Shanghai	Shanghai	China
13	Shanxi Provincial People's Hospital	Shanxi	Shanxi	China
14	The Second Affiliated Hospital of Kunming Medical University	Kunming	Yunnan	China