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WMT: The Neural Substrates for Working Memory Training

Sponsor
China Rehabilitation Research Center (Other)
Overall Status
Unknown status
CT.gov ID
NCT03012269
Collaborator
(none)
40
Enrollment
1
Location
2
Arms

Study Details

Study Description

Brief Summary

This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Working memory training
 Phase 2/Phase 3

Study Design

Study Type:
Interventional
Anticipated Enrollment :
40 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
The Study on the Brain Mechanisms for the Rehabilitation of Working Memory Deficits in Patients With Acquired Brain Injury Using Multimodal Magnetic Resonance Imaging
Study Start Date :
Oct 1, 2012
Anticipated Primary Completion Date :
Oct 1, 2018

Arms and Interventions

Arm Intervention/Treatment
Experimental: Working Memory Training

The subjects of experimental group received a series of working memory training, 30 min for 5 days per week during 6 weeks.

Behavioral: Working memory training
No Intervention: Non-Working Memory Training

The subjects of control group performed traditional cognitive rehabilitation without working memory training, 30 min for 5 days per week during 6 weeks.

Outcome Measures

Primary Outcome Measures

  1. Training-induced brain activations during working memory tasks in fMRI [six weeks]

    Training-induced increased and decreased brain activations (Number of voxels) during n-back verbal WM task compared to the pre-training baseline

Secondary Outcome Measures

  1. The fluid intelligence measured by Raven's Standard Progressive Matrices (RSPM) test [six weeks]

  2. Attention ability assessed by Stroop color-word test [six weeks]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 55 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Right handedness

  • Diagnosis of traumatic brain injury or stroke

  • Course of disease within one year

  • The score of MoCA test > 24

  • Able to understand instructions

Exclusion Criteria:

  • Aphasia, unilateral spatial neglect, agnosia, apraxia

  • Hearing impairment or visual impairment

  • History of taking psychiatric drugs

Contacts and Locations

Locations

Site City State Country Postal Code
1 Department of Rehabilitation Evaluation, China Rehabilitation Research Center Beijing Beijing China 100068

Sponsors and Collaborators

  • China Rehabilitation Research Center

Investigators

  • Principal Investigator: Xiaoping Yun, MD, Department of Rehabilitation Evaluation, China Rehabilitation Research Center

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Yun XiaoPing, Director of Department of Rehabilitation Evaluation, China Rehabilitation Research Center
ClinicalTrials.gov Identifier:
NCT03012269
Other Study ID Numbers:
  • NSFC-81272165
First Posted:
Jan 6, 2017
Last Update Posted:
Jan 6, 2017
Last Verified:
Jan 1, 2017

Study Results

No Results Posted as of Jan 6, 2017