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Relation Between Bone Density and the Regulation of Mineral Metabolism in Renal Stone Formers

Sponsor
University Hospital Inselspital, Berne (Other)
Overall Status
Completed
CT.gov ID
NCT00416052
Collaborator
(none)
90
Enrollment
1
Location
27
Duration (Months)
3.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Accumulating evidence indicated that renal calcium stone formers often exhibit a low bone density. Therefore we want to test the hypothesis, that the mineral (calcium) metabolism is differently regulated in calcium stone formers with low as opposed to high bone density.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    There is epidemiological evidence associating renal calcium stones and decreased bone mineral density (BMD). The decreased BMD in calcium stone formers is linked to hypercalciuria and both subtypes, fasting as well as absorptive hypercalciuria are associated with a diminished BMD. Higher 1,25-vitamin D plasma concentrations and lower PTH levels are encountered under free-choice diet conditions in patients diagnosed with absorptive and fasting hypercalciuria when compared to normocalciuric stone formers. Reports studying the BMD of stone formers and its link with mineral metabolism variables and urinary calcium excretion under different calcium intakes are rare.

    We hypothesize now that PTH and 1,25-vitamin D change differently when calcium stone formers with high, intermediate and low BMD are challenged by a low calcium diet.

    Study Design

    Study Type:
    Observational
    Observational Model:
    Case-Only
    Official Title:
    Relation Between Bone Mineral Density and the Regulation of Mineral Metabolism in Renal Stone Formers
    Study Start Date :
    Mar 1, 2004
    Study Completion Date :
    Jun 1, 2006

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • passage of at least one calcium containing kidney stone
      Exclusion Criteria:

      • established cause of calcium stone formation (sarcoidosis, primary hyperparathyroidism etc.)

      • creatinine clearance < 60 ml/min

      • urinary tract infection

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Dept. Nephrology & Hypertension, Univ. Hospital Bern Bern Switzerland 3010

      Sponsors and Collaborators

      • University Hospital Inselspital, Berne

      Investigators

      • Study Director: Felix J Frey, MD, University of Bern

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00416052
      Other Study ID Numbers:
      • BE001
      First Posted:
      Dec 27, 2006
      Last Update Posted:
      May 19, 2011
      Last Verified:
      May 1, 2011
      Keywords provided by , ,
      calcium
      calciuria
      PTH
      1,25-vitamin D
      Calcitriol
      bone mineral density
      osteodensitometry
      Additional relevant MeSH terms:
      Nephrolithiasis
      Kidney Calculi

      Study Results

      No Results Posted as of May 19, 2011