The Relation of High Sensitivity C Reactive Protein and Total Leucocytic Count Levels in Threatened Abortion
Study Details
Study Description
Brief Summary
to identify the relation between maternal serum high sensitivity C reactive protein and total and differential leucocytic count values in healthy pregnant women with threatened abortion and the outcome of pregnancy
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
observational prospective cohort research will be pregnant women attending to obstetrics and gynecology department of University Hospital. After enrollment, participants will be divided into two groups:
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Study group: had 120 healthy women presenting with threatened miscarriage.
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Control group: had 120 healthy women with an uncomplicated single pregnancy. informed permission will be obtained. All cases subjected to the following: taking complete history, General examination, Special investigations including Obstetric ultrasonography for assessment of gestational age, and exclusion of congenital anomalies or multi-fetal gestation. Laboratory investigations including Estimation of the complete blood picture (CBC), Highly sensitive CRP (HS-CRP) single measurement, Women over 1st trimester abdominal ultrasonographic examination (6-13weeks) using Toshiba with transabdominal transducer probe frequency of 7 MHz to evaluate the following data: Measuring of the fetal crown-rump length (CRL) done to confirm the fetal gestational age and the viability of the fetus. Gestational age will be calculated from the beginning of the last regular menstrual cycle. Women who had hormone therapy or progesterone supplements, as well as pregnancies with a discrepancy between LMP and crown rump length of more than three days, were excluded from the research.
Pregnant women will be under close follow up every 2 weeks by: Obstetric U/S, Measure blood pressure and inform us if severe bleeding occurs.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Study group 120 healthy women presenting with threatened miscarriage. |
Diagnostic Test: maternal serum C reactive protein
maternal serum high sensitivity C reactive protein
Diagnostic Test: total leucocytic count levels
total leucocytic count levels
Diagnostic Test: differential leucocytic count levels
differential leucocytic count levels
|
| Control group 120 healthy women with an uncomplicated single pregnancy. |
Diagnostic Test: maternal serum C reactive protein
maternal serum high sensitivity C reactive protein
Diagnostic Test: total leucocytic count levels
total leucocytic count levels
Diagnostic Test: differential leucocytic count levels
differential leucocytic count levels
|
Outcome Measures
Primary Outcome Measures
- Highly sensitive CRP (HS-CRP) [9 months]
A high level of hs-CRP, i.e., greater than 3 mg/L,
- total leucocytic count [9 months]
measures the number of white blood cells (WBCs) in blood
Eligibility Criteria
Criteria
Inclusion Criteria:
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Single intrauterine pregnancy with vaginal hemorrhage and/or abdominal pain in the study group,
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an ultrasound showing an intrauterine gestational sac with a live fetus and a regular fetal heartbeat, with/without a sub-chorionic hematoma,
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healthy women who come for routine antenatal care with spontaneous pregnancy.
Exclusion Criteria:
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Age over 40
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smoking
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multiple pregnancies
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endocrinological diseases
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history of repeated spontaneous abortions.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Beni-suef university Hospital | Banī Suwayf | Beni Suef | Egypt | 62521 |
Sponsors and Collaborators
- Beni-Suef University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- C reactive protein abortion