The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs

Sponsor

Selcuk University (Other)

Overall Status

Recruiting

CT.gov ID

NCT04646525

Collaborator

(none)

300

Enrollment

Location

Anticipated Duration (Months)

74.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

We aimed to find out whether the tonsils and nasal tissues of pediatric patients are the main factors that protects the children's immune system against COVID-19 infection.

Condition or Disease	Intervention/Treatment	Phase
Covid19 Immune Deficiency Tonsillitis Tonsil Hypertrophy Adenoiditis Adenoid Hypertrophy	Diagnostic Test: Physical examination

Detailed Description

Since it is known that the tonsil and adenoid tissues that are known as a secondary lymphoid organ, which form the first line of defense, are more active in childhood than adults, especially in the childhood age group, and since it has been scientifically shown that patients diagnosed with COVID-19 infection in the pediatric age group overcome this disease lightly than adults, we aimed to reveal whether the defined tonsil and adenoid tissues are the main factors that protect the children's immune system against COVID-19 infection.

Study Design

Study Type:

Observational

Anticipated Enrollment :

300 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

The Relationship Between Mild Covid-19 Infection in Pediatric Patients and Protection of Secondary Lymphoid Organs

Actual Study Start Date :

Oct 1, 2020

Anticipated Primary Completion Date :

Feb 1, 2021

Anticipated Study Completion Date :

Feb 1, 2021

Outcome Measures

Primary Outcome Measures

The primary outcome of our study was the evaluation of pediatric patients diagnosed with COVID-19 and who had COVID-19 infection in terms of adenoid and tonsillar tissue hypertrophy and the presence of chronic or recurrent infection. [2020-2021]
The structure of the tonsil and adenoid tissues will be examined by physical examination, and the presence of tonsil and adenoid hypertrophy, tonsillitis, and adenoiditis conditions will be identified. The severity of covid-19 will be determined according to the cases of patients with tonsil and adenoid tissue disorders, who are hospitalized in intensive care, have infiltration in the lungs, and receive oxygen support.

Eligibility Criteria

Criteria

Ages Eligible for Study:

1 Year to 16 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients with COVID-19 infection.
Patients aged between 1-16 years
Patients whose PCR test becomes negative

Exclusion Criteria:

Patients with lymphoid tissue malignant disease
Patients with known lung disease
Patients with known systemic disease

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Selcuk University	Konya	Selcuklu	Turkey	42100

Sponsors and Collaborators

Selcuk University

Investigators

Principal Investigator: Merih Onal, Assist. Prof., Selcuk University

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:

Merih Onal, Assistant Professor, Selcuk University

ClinicalTrials.gov Identifier:

NCT04646525

Other Study ID Numbers:

2020/480

First Posted:

Nov 30, 2020

Last Update Posted:

Nov 30, 2020

Last Verified:

Nov 1, 2020

Individual Participant Data (IPD) Sharing Statement:

Undecided

Plan to Share IPD:

Undecided

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Merih Onal, Assistant Professor, Selcuk University

pediatric

covid19

İmmune system

Additional relevant MeSH terms:

COVID-19

Tonsillitis

Immunologic Deficiency Syndromes

Hypertrophy

Study Results

No Results Posted as of Nov 30, 2020