Relationship Between Homocysteine and BMD
Study Details
Study Description
Brief Summary
The association between Homocysteine (Hcy) levels and bone mineral density (BMD) has been debated. Some studies have found a relationship between increased Hcy plasma levels and BMD in contrast; other studies have not found a relationship. The purpose of our study was to investigate whether or not Hcy plasma levels are related to BMD in a group of postmenopausal women.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Hyperhomocysteinemia
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Diagnostic Test: Dual-Energy X-ray Absorptiometry (DXA)
BMD expressed in absolute values as g/cm2 and T-scores
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Normal Hcy levels
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Diagnostic Test: Dual-Energy X-ray Absorptiometry (DXA)
BMD expressed in absolute values as g/cm2 and T-scores
|
Outcome Measures
Primary Outcome Measures
- BMD expressed in absolute values as g/cm2 [one year before or after Homocysteine levels]
- Lumbar spine T-score [one year before or after Homocysteine levels]
- Femoral neck T-score [one year before or after Homocysteine levels]
- Total hip T-score [one year before or after Homocysteine levels]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Postmenopausal women
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BMD measured by dual-energy X-ray absorptiometry (DXA)
Exclusion Criteria:
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Primary ovarian failure
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Early menopause
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Cardiovascular, liver, or renal diseases
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Surgical menopause
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History of cancer
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Receiving treatment known to influence levels of Hcy or bone mineralization (folates or vitamin B12 supplements, menopausal hormonal treatment, corticosteroids, anticonvulsants, heparin, thiazide diuretics, and antiresorptive agents).
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Hospital Universitario Quiron Dexeus | Barcelona | Spain | 08028 |
Sponsors and Collaborators
- Fundación Santiago Dexeus Font
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- Bahtiri E, Islami H, Rexhepi S, Qorraj-Bytyqi H, Thaçi K, Thaçi S, Karakulak C, Hoxha R. Relationship of homocysteine levels with lumbar spine and femur neck BMD in postmenopausal women. Acta Reumatol Port. 2015 Oct-Dec;40(4):355-62. Review.
- Cagnacci A, Bagni B, Zini A, Cannoletta M, Generali M, Volpe A. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone. 2008 Feb;42(2):314-20. doi: 10.1016/j.bone.2007.10.022. Epub 2007 Nov 12.
- Enneman AW, Swart KM, Zillikens MC, van Dijk SC, van Wijngaarden JP, Brouwer-Brolsma EM, Dhonukshe-Rutten RA, Hofman A, Rivadeneira F, van der Cammen TJ, Lips P, de Groot CP, Uitterlinden AG, van Meurs JB, van Schoor NM, van der Velde N. The association between plasma homocysteine levels and bone quality and bone mineral density parameters in older persons. Bone. 2014 Jun;63:141-6. doi: 10.1016/j.bone.2014.03.002. Epub 2014 Mar 12.
- Mittal M, Verma R, Mishra A, Singh A, Kumar V, Sawlani KK, Ahmad MK, Mishra P, Gaur R. Relation of Bone Mineral Density with Homocysteine and Cathepsin K levels in Postmenopausal Women. Indian J Endocrinol Metab. 2018 Mar-Apr;22(2):261-266. doi: 10.4103/ijem.IJEM_575_17.
- FSD-HCY-2020-05