Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder
Study Details
Study Description
Brief Summary
We aim to assess the baseline oxytocin levels in individuals with borderline personality disorder and correlate those levels with social behavior, and compare the results with controls.
Primary Hypothesis (H1):
There is a significant difference in trust-related behavior as measured by oxytocin (OXT) levels between borderline personality disorder (BPD) patients and healthy controls.
Secondary Hypotheses:
H2: The trust-related behavior in BPD patients is significantly influenced by their level of emotional sensitivity. Specifically, higher emotional sensitivity in BPD patients is associated with lower trust-related behavior and vice-versa.
H3: There is a significant correlation between trust-related behavior and childhood trauma in BPD patients. BPD patients with higher levels of reported childhood trauma will exhibit lower trust-related behavior compared to those with lower levels of trauma.
H4: Trust-related behavior in BPD patients varies depending on their attachment styles. Specifically, BPD patients with insecure attachment styles will exhibit lower trust-related behavior compared to those with secure attachment styles.
H5: There is a significant correlation between trust-related behavior and BPD severity. Patients with more severe BPD symptoms will exhibit lower trust-related behavior compared to those with less severe symptoms.
H6: The levels of OXT in BPD patients will significantly correlate with their reported levels of emotional sensitivity, childhood trauma, attachment styles, and BPD severity.
These hypotheses aim to address the complexities surrounding the modulation of trust-related behavior by oxytocin in BPD patients, taking into account various factors like emotional sensitivity, childhood adversity, attachment styles, and BPD severity. By testing these hypotheses, the study aims to provide a comprehensive understanding of the interplay between these factors in influencing trust-related behavior in BPD patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Cases Participants with borderline personality disorder who meet the inclusion criteria |
Other: baseline serum oxytocin levels
Both cases and controls will be assessed for their baseline serum oxytocin levels
Other: Emotional Sensitivity test
To assess the level of emotional sensitivity in the participant
Other: Neuro-economical game
A game played to assess the trust-index of participants
Other: Childhood Trauma Questionnaire
to assess childhood trauma score
Other: Relationships Questionnaire
to assess attachment type
Other: demographic questionnaire
To obtain basic data on demographics
|
| Controls Participants without borderline personality disorder, who meet the inclusion criteria |
Other: baseline serum oxytocin levels
Both cases and controls will be assessed for their baseline serum oxytocin levels
Other: Emotional Sensitivity test
To assess the level of emotional sensitivity in the participant
Other: Neuro-economical game
A game played to assess the trust-index of participants
Other: Childhood Trauma Questionnaire
to assess childhood trauma score
Other: Relationships Questionnaire
to assess attachment type
Other: demographic questionnaire
To obtain basic data on demographics
|
Outcome Measures
Primary Outcome Measures
- Correlation of Oxytocin levels and trust index [Day 1]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Individuals with borderline personality disorder will qualify as cases
-
controls will be age, gender matched individuals without any psychiatric/mental health concerns
Exclusion Criteria:
-
for all: pregnancy, hormonal or neurological disorders, and any kind of regular medication
-
additional exclusion criteria for cases: a lifetime diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or significant neurological disease, current alcohol/ drug dependence
-
for controls: MacLEan screening instrument for BPD will be used at the time of screening to exclude BPD diagnosis in controls
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | SUNY Upstate Medical University | Syracuse | New York | United States | 13210 |
Sponsors and Collaborators
- State University of New York - Upstate Medical University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2060971