Relationship Between Vestibular Function and Topographic Memory
Study Details
Study Description
Brief Summary
The purpose of this study is to evaluate visual and nonvisual topographic memory impairment and its relationship to vestibular function in humans. Topographic memory refers to the ability to remember current and past locations in topographic (navigational) space and to make and/or adjust to spatial transformations using such memories. Performance on each of these topographic memory tasks will be compared to performance on a set of comparable nontopographic memory tasks. Topographic impairments represent some of the earliest cognitive deficits observed in Alzheimer's Disease, and the brain areas involved in topographic memory are the first to show degenerative changes.
| Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
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Outcome Measures
Primary Outcome Measures
- Determine relationship between topographic memory and vestibular function [14 days]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Males or females of all racial and ethnic groups between the ages of 70 and 85 years of age;
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Montreal Cognitive Assessment (MOCA) (http://www.mocatest.org) score of >24;
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No known history or current evidence of stroke, trauma, psychiatric illness, or other insult to the brain;
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No current use of psychoactive medicine other than caffeine (100 mg/day) or alcohol (1-2 drinks per night);
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Normal sleep (at least an average of 7 hours for four days prior to participation);
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Able and willing to comply with study requirements including following instructions to complete vestibular and neuropsychological testing; and
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Have full understanding of all elements of provide signature and dating of the written informed consent prior to the initiation of procedures specified in protocol.
Exclusion Criteria:
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<70 or >85 yrs of age;
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MOCA score of <25;
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History, or current evidence, of stroke, trauma, psychiatric illness, or other insult to the brain;
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Prior history of inner-ear balance problems;
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Current use of psychoactive medicine other than moderate caffeine or alcohol use;
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Acute or chronic sleep deprivation during the week prior to participation (<7 hours/night on average for four nights prior to participation).
Other Restrictions:
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No alcohol use on the night before the vestibular testing
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7 hours minimum sleep the night before vestibular testing
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No eye make-up can be worn on the day of the vestibular test due to possible interference with vestibular-ocular reflex testing apparatus
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ears of Texas, PA | San Antonio | Texas | United States | 78215 |
| 2 | Michael Roman, PhD, LSSP | San Antonio | Texas | United States | 78229 |
Sponsors and Collaborators
- Biomedical Development Corporation
- National Center for Advancing Translational Science (NCATS)
- Michael Roman, PhD, LSSD
- Ears of Texas, PA
Investigators
- Principal Investigator: Fred Previc, PhD, Biomedical Development Corporation
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 121101-R43TR000645-01
- R43TR000645