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Relationship of Endoplasmic Reticulum Stress and Adenoid Diseases

Sponsor
Selcuk University (Other)
Overall Status
Completed
CT.gov ID
NCT04583631
Collaborator
(none)
54
Enrollment
1
Location
9
Actual Duration (Months)
6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Adenoid tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of cells. The purpose of the study was to explore the correlation among ER stress and adenoid tissue disorders and to explain the structure of diseases related to the immune system.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Adenoidectomy surgery

Study Design

Study Type:
Observational
Actual Enrollment :
54 participants
Observational Model:
Case-Control
Time Perspective:
Prospective
Official Title:
Relationship Between Apoptosis and er Stress in Chronic Adenoiditis and Adenoid Hypertrophy
Actual Study Start Date :
Nov 1, 2018
Actual Primary Completion Date :
Aug 1, 2019
Actual Study Completion Date :
Aug 1, 2019

Arms and Interventions

Arm Intervention/Treatment
Chronic adenoiditis

Patients with hypertrophy and those out of hypertrophy were determined and those who had purulant rhinorrhea signs and rate of adenoids-choana below 50% were categorized that chronic adenoiditis.

Procedure: Adenoidectomy surgery
All patients underwent adenoidectomy under general anesthesia by routine curettage method and adenoid tissues were put in formaldehyde and sent to the genetics department for the exploration of ER stress and apoptosis markers.
Adenoid hypertrophy

Patients who have snoring and those whose adenoid choana rate is greater than 50% were categorized that adenoid hypertrophy group.

Procedure: Adenoidectomy surgery
All patients underwent adenoidectomy under general anesthesia by routine curettage method and adenoid tissues were put in formaldehyde and sent to the genetics department for the exploration of ER stress and apoptosis markers.

Outcome Measures

Primary Outcome Measures

  1. Correlation of ER stress and apoptosis with chronic adenoiditis and adenoid hypertrophy [2018-2019 (1 year)]

    Our primary outcome was to evaluate providing that ER stress and apoptosis reaction performing in chronic adenoiditis and adenoid hypertropy, which is related with the immune system of children.

Eligibility Criteria

Criteria

Ages Eligible for Study:
3 Years to 9 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Patients with the clinical diagnosis of chronic adenoiditis and adenoid hypertrophy.
Exclusion Criteria:

  • Systemic diseases

  • Other otolaryngological

Contacts and Locations

Locations

Site City State Country Postal Code
1 Selcuk University Konya Selcuklu Turkey 42100

Sponsors and Collaborators

  • Selcuk University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
Merih Onal, Assistant Professor, Selcuk University
ClinicalTrials.gov Identifier:
NCT04583631
Other Study ID Numbers:
  • 2018-18
First Posted:
Oct 12, 2020
Last Update Posted:
Sep 27, 2021
Last Verified:
Sep 1, 2021
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Merih Onal, Assistant Professor, Selcuk University
Adenoidectomy
; Endoplasmic Reticulum

Study Results

No Results Posted as of Sep 27, 2021