The Relationship of Phthalate Exposure During Pregnancy and Preeclampsia
Study Details
Study Description
Brief Summary
Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. Prenatal exposure phthalates would disrupt the level of sex hormone in pregnant women, which results in preeclampsia. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| healthy pregnant woman pregnant woman without any disease of pregnancy |
Other: test Phthalates, estrogen and progesterone
test mothers Phthalates in their urine, and test estrogen and progesterone receptor in placental tissue
|
| pregnant woman with preeclampia pregnant woman with preeclampia but without any other disease of pregnancy |
Other: test Phthalates, estrogen and progesterone
test mothers Phthalates in their urine, and test estrogen and progesterone receptor in placental tissue
|
Outcome Measures
Primary Outcome Measures
- Phthalates in urine [37 weeks to 40 weeks gestation]
Collect the urine of pregnant women and test the abundance of Phthalates
Secondary Outcome Measures
- The female progesterone [37 weeks to 40 weeks gestation]
Collect the placenta tissue of pregnant women and test the abundance of estrogen progesterone receptor
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Singleton pregnancy
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Term pregnancy with the gestational age of 37-40 weeks
Exclusion Criteria:
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Maternal systemic diseases (hypertension disorders, immunological diseases) or pregnant complications (polyhydramnios, oligohydramnios, diabetes mellitus, intrahepatic cholestasis of pregnancy)
-
Delivery before 37 weeks or after 40 weeks
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | department of obstetrics of Second Affiliated Hospital of Wenzhou Medical University | Wenzhou | Zhejiang | China | 325027 |
Sponsors and Collaborators
- Second Affiliated Hospital of Wenzhou Medical University
Investigators
- Study Director: Ying Hua, Second Affiliated Hospital of Wenzhou Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SAHoWMU-CR2020-07-210