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The Relationship of Sevoflurane Consumption With Metabolic Age

Sponsor
Inonu University (Other)
Overall Status
Completed
CT.gov ID
NCT06018597
Collaborator
(none)
79
Enrollment
1
Location
5.7
Actual Duration (Months)
13.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this clinical study is to determine the consumption of sevoflurane, which is one of the inhalation anesthetics, with metabolic age and basal metabolic rate. The basal metabolic rates and metabolic ages of the patients who will be given sevoflurane- maintained general anesthesia were measured preoperatively. The relationship between the amount of sevoflurane consumption and the measured data of the patients in the postoperative period was examined.

Condition or Disease Intervention/Treatment Phase
  • Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL

Detailed Description

Standard monitoring, BIS, TOF (train of four) were performed from the premedication application. Aspect A 2000 (Aspect Medical Systems, Newton) monitor and single-chip BIS electrodes will be used for BIS. The total amount of sevoflurane consumed and MAK values of these components will be recorded. Chronological age, metabolic age, BMR, height, weight, ideal body weight, BMI, body adiposity, body fluid ratio, body fluid care, fat mass, lean body weight, muscle registered, visceral adiposity, obesity degree in the preoperative period of the patients. Values, ASA scores and demographic data will be recorded for the operation process, cutting time, anesthesia time, extubation time, total sevoflurane consumption throughout the case, and the relationship with basal metabolism and metabolic age will be evaluated.

Study Design

Study Type:
Observational
Actual Enrollment :
79 participants
Observational Model:
Case-Control
Time Perspective:
Prospective
Official Title:
The Relationship of Sevoflurane Consumption With Metabolic Age
Actual Study Start Date :
Sep 9, 2022
Actual Primary Completion Date :
Mar 1, 2023
Actual Study Completion Date :
Mar 3, 2023

Arms and Interventions

Arm Intervention/Treatment
percent age difference < -6.6%

The percentage age difference in the negative direction represents patients whose metabolic age is greater than their chronological age. When we analyze the ROC analysis in the negative direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percentage age difference is -6,6%. This group refers to those whose percentage age difference is less than -6.6%

Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL
No procedure was performed on the patient other than routine anesthesia management.We compared sevoflurane consumption amount in the patient undergoing general anesthesia with sevoflurane according to their metabolic age.
Other Names:
  • No procedure was performed on the patient other than routine anesthesia management.

    		•
    percent age difference -6.6% to 11.7% those between

    When we analyze the ROC analysis in the negative direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percentage age difference is -6,6%. When we analyze the ROC analysis in the positive direction, the cut-off value of the percent age difference is 11.7%. This group refers to those whose percentage age difference between -6.6% and 11.7%

    Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL
    No procedure was performed on the patient other than routine anesthesia management.We compared sevoflurane consumption amount in the patient undergoing general anesthesia with sevoflurane according to their metabolic age.
    Other Names:
  • No procedure was performed on the patient other than routine anesthesia management.

    		•
    percent age difference > 11.7%

    the percent age difference in the positive direction represents patients whose metabolic age is less than their chronological age. When we analyze the ROC analysis in the positive direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percent age difference is 11.7%. This group refers to those whose percentage age difference is more than 11.7%

    Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL
    No procedure was performed on the patient other than routine anesthesia management.We compared sevoflurane consumption amount in the patient undergoing general anesthesia with sevoflurane according to their metabolic age.
    Other Names:
  • No procedure was performed on the patient other than routine anesthesia management.

    		•

    Outcome Measures

    Primary Outcome Measures

    1. consumption of sevoflurane [patients during surgery]

      Reducing patients' consumption of sevoflurane according to metabolic law

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 65 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    Between the ages of 18-65 who are scheduled for rhinoplasty or septoplasty with ASA I-II Cases lasting 1 to 3 hours

    Exclude Criteria:

    Patients at high risk of malignant hyperthermia, with a history of allergy to general anesthesia or any of the drugs to be used in the study, accepted as ASA III- ASA IV

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Inonu universitesi Malatya Turkey 44050

    Sponsors and Collaborators

    • Inonu University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    DUYGU DEMİROZ, associate professor, Inonu University
    ClinicalTrials.gov Identifier:
    NCT06018597
    Other Study ID Numbers:
    • Inonu 2022/92
    First Posted:
    Aug 30, 2023
    Last Update Posted:
    Aug 30, 2023
    Last Verified:
    Aug 1, 2023
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Product Manufactured in and Exported from the U.S.:
    Yes
    Keywords provided by DUYGU DEMİROZ, associate professor, Inonu University
    Sevoflurane Consumption, Metabolic Age, Tanita
    Additional relevant MeSH terms:
    Sevoflurane

    Study Results

    No Results Posted as of Aug 30, 2023