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Relationship of Staphylococcal Colonization to Infection

Sponsor
Veterans BioMedical Research Institute (Other)
Overall Status
Withdrawn
CT.gov ID
NCT00766259
Collaborator
(none)
0
Enrollment
35
Duration (Months)

Study Details

Study Description

Brief Summary

Inpatients will be prospectively have nares screened and MRSA strains collected. All clinical MRSA strains of patients will also be prospectively collected. A sensitive strain discrimination test of spa typing will be used to determine if the strains are related. Hypotheses are

  1. Strain colonization durations vary and may be very short in days to weeks.

  2. Colonizing strains rarely infect 3) Both 1 and 2 may be affected by the patient's co-morbidity.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Patients of special interest:

    1. Skin and soft tissue infection

    2. Nursing home patients

    3. Vascular patients with leg lesions

    4. ICU patients

    5. Hemodialysis patients

    6. Outpatients without history of infections(controls) will have nares screened for MRSA and then monthly for 1 year.

    All strains will be saved and spa typed. Analysis of the data will be performed to answer the questions and hypotheses and to answer is the screening effort and the isolation of patients for MRSA as is in current practice worthwhile and is there any scientific data to support this practice

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    0 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Relationship of Staphylococcal Colonization to Infection
    Study Start Date :
    Jul 1, 2009
    Anticipated Primary Completion Date :
    Jun 1, 2011
    Anticipated Study Completion Date :
    Jun 1, 2012

    Arms and Interventions

    Arm Intervention/Treatment
    1

    Hemodialysis
    2

    Intensive care
    3

    vascular patients with open wounds
    4

    nursing home
    5

    skin infections
    6

    control- ambulatory care clinic patients with no infections

    Outcome Measures

    Primary Outcome Measures

    1. Percent of infection strains which were also colonizer earlier [3 years]

    Secondary Outcome Measures

    1. Duration of strain colonization among co-morbidity cohorts [3 years]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Admitted and one of the co-morbid groups

    • Ambulatory care patient with no infections

    Exclusion Criteria:
    • All others

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Veterans BioMedical Research Institute

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Veterans BioMedical Research Institute
    ClinicalTrials.gov Identifier:
    NCT00766259
    Other Study ID Numbers:
    • Eng-MRSA
    First Posted:
    Oct 3, 2008
    Last Update Posted:
    Apr 5, 2021
    Last Verified:
    Mar 1, 2021
    Keywords provided by Veterans BioMedical Research Institute
    methicillin-resistant Staphylococcus
    colonization
    Additional relevant MeSH terms:
    Infections
    Communicable Diseases

    Study Results

    No Results Posted as of Apr 5, 2021