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Relationships Among Body Mass Index, Body Balance and Bone Mineral Density in Postmenopausal Women

Sponsor
Cairo University (Other)
Overall Status
Completed
CT.gov ID
NCT03280693
Collaborator
(none)
48
Enrollment
6
Actual Duration (Months)

Study Details

Study Description

Brief Summary

Body composition, bone mineral density (BMD), and body balance are important factors that threaten postural control. They act as vital elements in the vicious circle that leads to fracture occurrence in elderly population, particularly postmenopausal women.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: Diagnostic test

Detailed Description

  • The purpose of the current study was to evaluate the relationships among body mass index (BMI), body balance, and BMD (g/cm²) in postmenopausal women to be able to identify risk factors for fractures.

  • Forty-eight postmenopausal women participated in this study. Body balance was assessed using Berg Balance Scale (BBS), while BMD of the lumbar spine was measured by dual energy X-ray absorptiometry (DEXA) scan.

The positive correlation between body balance and BMD in the current study can be explained that balance is controlled by sensory input, central processing, and neuromuscular responses. The sensory components consist of the vestibular, visual, and proprioceptive systems. An effective motor response requires an intact neuromuscular system and sufficient muscle strength to return the COG within the BOS when balance is disturbed. Postural balance in individuals with osteoporosis is significantly worse than in healthy individuals. Moreover, it was determined that balance scores in individuals with osteoporosis were 11% worse than scores of healthy individuals. Furthermore, exaggerated thoracic kyphotic curve is not only a disfiguring effect of osteoporosis but may also play a significant role in gait disorder, instability, and risk of falls.

In addition, back pain has a harmful impact on both balance and functional mobility in women with osteoporosis. Individuals with back pain may reduce their level of physical activity and, as a result, become weak in muscles required for balance and functional mobility. Impairment of the musculoskeletal and/or the neuromuscular system may negatively affect both balance and functional mobility.

In the same context, it was proved that women with decreased BMD and increased thoracic kyphosis presented greater body sway in the anterior/posterior direction on the force platform indicating more displacement of foot center of pressure (COP). They also confirmed that postmenopausal women with low BMD and increased thoracic kyphosis depend more on the hip strategy to maintain their postural control. This in turn probably causes more displacement of foot COP, thus causing greater body sway in all directions in comparison with the ankle strategy. it was also showed that women with loss of bone mass and increased thoracic kyphosis presented less foot COP displacement in the AP direction compared with the control group (with normal bone mass and normal thoracic curve.

The current study results also revealed that BMI was negatively correlated with both BMD and body balance in postmenopausal women. This can be illustrated that obese elderly women are often afraid of falls and sustaining fractures, so they prefer immobility and minimize their physical activity as much as possible. Because bone is formed when needed and resorbed when not needed as known as Wolff's law, BMD decreases and osteopenia/osteoporosis develops. Low BMD affect bone health as it leads to fragile weak bone and this in turn disturbs postural control and body balance. Additionally, obese women fail to control their center of gravity (COG) within base of support (BOS) disturbing their postural control and body balance, increasing risk of falls and making them more liable to fractures.

Study Design

Study Type:
Observational
Actual Enrollment :
48 participants
Observational Model:
Case-Only
Time Perspective:
Retrospective
Official Title:
Relationships Among Body Mass Index, Body Balance and Bone Mineral Density
Actual Study Start Date :
May 1, 2015
Actual Primary Completion Date :
Nov 1, 2015
Actual Study Completion Date :
Nov 1, 2015

Outcome Measures

Primary Outcome Measures

  1. correlation between BMI and body balance [7 months]

    correlation analysis between BMI and body balance

  2. correlation between BMI and BMD [7 months]

    correlation analysis between BMI and BMD

Eligibility Criteria

Criteria

Ages Eligible for Study:
50 Years to 60 Years
Sexes Eligible for Study:
Female
Inclusion Criteria:
  • postmenopausal women with ages range from 50 to 60 years
Exclusion Criteria:

  • participation in sports

  • vertebrobasillar insufficiency

  • poor diet

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Cairo University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
Azza Mohammed, Principal invstigator, Cairo University
ClinicalTrials.gov Identifier:
NCT03280693
Other Study ID Numbers:
  • P.T.REC/012/00731
First Posted:
Sep 12, 2017
Last Update Posted:
Sep 12, 2017
Last Verified:
Sep 1, 2017
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Azza Mohammed, Principal invstigator, Cairo University
Body mass index,
Bone density
Balance
Postmenopause
Additional relevant MeSH terms:
Osteoporosis

Study Results

No Results Posted as of Sep 12, 2017