VERDICT: Venous Thromboembolism in Renally Impaired Patients and Direct Oral Anticoagulants
Study Details
Study Description
Brief Summary
In renally impaired patients with acute venous thromboembolism (VTE), standard-of-care (SOC) anticoagulation, i.e. heparins-vitamin K antagonists (VKA), at therapeutic dosage is associated with an increased risk of thromboembolic and bleeding complications compared to patients with normal renal function. Direct oral anticoagulants (DOAs) have been shown to be at least as effective and safe as SOC in VTE treatment. But in the clinical trials, moderate renally impaired patients were poorly represented and patients with severe renal insufficiency not at all. So no dose reduction was considered.
Surprisingly, DOAs have been approved for VTE treatment in moderate and severe renally impaired patients. There is need to evaluate a reduced dose of DOAs for VTE treatment in patients with moderate and severe renal insufficiency.
We plan to evaluate reduced doses of 2 DOAs (apixaban, rivaroxaban) compared to SOC in VTE patients with moderate or severe renal insufficiency in terms of net clinical benefit (recurrent VTE and major bleeding) at 3 months.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 3 |
Detailed Description
In renally impaired patients with acute venous thromboembolism (VTE), standard-of-care (SOC) anticoagulation, i.e. heparins-vitamin K antagonists (VKA), at therapeutic dosage is associated with an increased risk of thromboembolic and bleeding complications compared to patients with normal renal function. These patients represent more than 20% of the VTE population in clinical practice. Direct oral anticoagulants (DOAs) have been shown to be at least as effective and safe as SOC in VTE treatment. But in the clinical trials, moderate renally impaired patients were poorly represented (<10%) and patients with severe renal insufficiency not at all. So no dose reduction was considered.
The new DOAs have also been developed for stroke prevention in atrial fibrillation (SPAF). Patients including in AF trials are generally older and more prone to present renal impairment (>20%) than in VTE trials. So a reduced dose of DOAs was evaluated and shown to be at least as effective as, and safer than VKA in the subgroup of patients with moderate renal insufficiency (creatinine clearance between 30 to 50 ml/min).
Surprisingly, DOAs have been approved for VTE treatment and SPAF in moderate and severe renally impaired patients (creatinine clearance between 15 to 30 mL/min). Moreover, patients have to receive a reduced dose of DOAs for SPAF but a full dose of DOAs for VTE that could be associated with an increased bleeding risk, as suggested by some subgroup analyses. So, there, there is need to evaluate a reduced dose of DOAs for VTE treatment in patients with moderate and severe renal insufficiency (creatinine clearance between 15 to 50 mL/min).
Apixaban and rivaroxaban appear to be the best candidates since:
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both are approved in France in VTE patients
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they have mixed pathway of elimination (hepatic and renal)
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they have several other pharmacological similarities and they respective clinical trials have shown similar efficacy and safety profiles when compared with SOC for VTE treatment.
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they do not need to be preceded by initial parenteral heparins on the contrary to dabigatran and edoxaban. This allows evaluating the impact of DOAs in renally impaired patients independently from the initial heparins effect
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a reduced dose regimen is available and approved in AF
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the evaluation of 2 DAOs allows evaluating the concept of this new class in renally impaired VTE patients independently from the pharmaceutical companies.
Finally we plan to evaluate reduced doses of 2 DOAs (apixaban, rivaroxaban) compared to SOC in VTE patients with moderate or severe renal insufficiency in terms of net clinical benefit (recurrent VTE and major bleeding) at 3 months.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: DOA : Direct Oral Anticoagulants The experimental group receiving DOA regimens: patients will be secondarily randomly assigned within DOAs group between: Apixaban (Eliquis® tablet) 10 mg bid for 7 days then 2.5 mg bid for 3 months Rivaroxaban (Xarelto® tablet) 15 mg bid for 21 days then 15 mg od for 3 months. |
Drug: Apixaban
Direct Oral Anticoagulant
Other Names:
Drug: Rivaroxaban
Direct Oral Anticoagulant
Other Names:
|
| Active Comparator: SOC : Standard Of Care The control group receiving the standard of care (SOC), i.e. heparins/VKA regimen. Patients will receive the current recommended therapy: subcutaneous or intravenous UFH/VKA in case of severe renal insufficiency and subcutaneous LMWH/VKA in case of moderate renal insufficiency for at least 5 days. VKA will begin concomitantly and continue for 3 months. |
Drug: Heparin
Standard Of Care
Drug: VKA
Standard Of Care
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Non inferiority of reduced doses of DOAs [Month 3]
To demonstrate that reduced doses of DOAs (rivaroxaban or apixaban) are non-inferior to standard of care (heparins/VKA) on the net clinical benefit (recurrent VTE and major bleeding) in renally impaired patients suffering from an acute VTE.
Secondary Outcome Measures
- Bleeding events [Month 3]
To demonstrate the non--inferiority of reduced dose of DOAs on the risk of major bleedings.
- Venous Thromboembolism (VTE) events [Month 3]
To demonstrate the non--inferiority of reduced dose of DOAs on the risk of recurrent VTE.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients with a moderate renal insufficiency defined by a creatinine clearance between 30 to 50 ml/min (Cockcroft and Gault formulae) or a severe renal insufficiency (between 15 to 29 ml/min)
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Patients with acute objectively confirmed symptomatic proximal deep-vein thrombosis (DVT) or pulmonary embolism (PE) (with or without deep-vein thrombosis), planned to be treated for at least 3 months
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Patients >18 years
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Life expectancy more than 3 months
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Social security affiliation
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Signed informed consent
Exclusion Criteria:
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Indication for anticoagulants other than VTE
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Active bleeding or a high risk of bleeding contraindicating anticoagulant treatment; a systolic blood pressure of more than 180 mm Hg or a diastolic blood pressure of more than 110 mm Hg
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Anticoagulation for more than 72 hours prior to randomization
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Chronic liver disease or chronic hepatitis
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Patient at high risk of bleeding
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Creatinine clearance <15 ml/min or end stage renal disease or indication for extra-renal dialysis
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Need for concomitant anti-platelet therapy other than aspirin 75-325 mg per day. However concomitant treatment with aspirin is discouraged in this population at bleeding risk.
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Concomitant use of a strong inhibitor of cytochrome P-450 3A4 (CYP3A4) (e.g., a protease inhibitor for human immunodeficiency virus infection or azole-antimycotics agents ketoconazole, itraconazole, voriconazole, posaconazole) or a CYP3A4 inducer (e.g., rifampin, carbamazepine, or phenytoin),
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Active pregnancy or expected pregnancy or no effective contraception
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Any contraindication listed in the local labeling of UFH, LMWH or VKA or oral anticoagulant.
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Cancer-associated VTE requiring long-term treatment with LMWH
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Life expectancy of less than 3 months.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | CH ARRAS | Arras | Boulevard Georges Besnier | France | 62022 |
| 2 | Chu Tours | Tours | Hôpital Trousseau | France | 37550 |
| 3 | CH d'Agen-Nérac | Agen | France | ||
| 4 | Chu Amiens | Amiens 1 | France | 80054 | |
| 5 | Chu Angers | Angers 9 | France | 49933 | |
| 6 | CH Besançon | Besancon | France | 25030 | |
| 7 | CHU de Bordeaux | Bordeaux | France | ||
| 8 | CHU La Cavale Blanche Brest | Brest | France | 29200 | |
| 9 | HIA de Brest | Brest | France | ||
| 10 | CHU Castelnau-le-Lez | Castelnau Le Lez | France | 34170 | |
| 11 | CH Louis Pasteur - Chartres | Chartres | France | ||
| 12 | Chu Clermont-Ferrand | Clermont-Ferrand | France | 63003 | |
| 13 | CHU Dijon | Dijon | France | 21034 | |
| 14 | Hôpital La Tronche Grenoble | Grenoble 9 | France | 38043 | |
| 15 | Hôpital Charles Foix - APHP Ivry sur Seine | Ivry sur Seine | France | 94200 | |
| 16 | Chu Limoges | Limoges | France | 87000 | |
| 17 | CHU Lyon | Lyon | France | 69000 | |
| 18 | HCL - Hôpital Edouard Herriot | Lyon | France | ||
| 19 | Chu Montpellier | Montpellier 5 | France | 34295 | |
| 20 | CHU de Nantes - Hôpital Bellier | Nantes | France | ||
| 21 | CHU de Nantes - Hôpital Hôtel Dieu | Nantes | France | ||
| 22 | CHU Nice | Nice | France | 06003 | |
| 23 | HEGP - APHP Paris | Paris | France | 75000 | |
| 24 | Hôpital Louis Mourier- APHP Paris | Paris | France | 75000 | |
| 25 | CHU de Rouen | Rouen | France | ||
| 26 | Chu Saint Etienne | Saint Etienne | France | 42055 | |
| 27 | Chu Strasbourg | Strasbourg | France | 67091 | |
| 28 | CH Toulon | Toulon | France | 83056 | |
| 29 | HIA de Toulon | Toulon | France | ||
| 30 | CHU Toulouse | Toulouse 9 | France | 31059 | |
| 31 | CH de Valenciennes | Valenciennes | France |
Sponsors and Collaborators
- Centre Hospitalier Universitaire de Saint Etienne
- Ministry of Health, France
Investigators
- Principal Investigator: MISMETTI Patrick, MD, CHU SAINT ETIENNE
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 1508189
- 2016-000858-35