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Renal Tubular Disorders in Egyptian Children

Sponsor
Sohag University (Other)
Overall Status
Completed
CT.gov ID
NCT04845815
Collaborator
(none)
58
Enrollment
1
Location
8.5
Actual Duration (Months)
6.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders. These disorders can lead to life threatening disturbances in electrolytes and acid-base balance. In Egypt, there is little data about these disorders. Many of these cases are diagnosed late, therefore Early suspicion for diagnosis can improve the overall clinical outcome of these children.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders. These disorders can lead to life threatening disturbances in electrolytes and acid-base balance. In Egypt, there is little data about these disorders. Many of these cases are diagnosed late, therefore Early suspicion for diagnosis can improve the overall clinical outcome of these children. As a result, starting management early will help those children have a better life. Therefore awareness about these disorders and long-term outcome is really important. The investigators present the clinical characterizations of many tubular disorder and the follow up in our center.

    The aim of this study is to reveal the different clinical presentations and the main lab features of renal tubular disorders in children to promote early recognition and management.

    Study Design

    Study Type:
    Observational [Patient Registry]
    Actual Enrollment :
    58 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Other
    Official Title:
    Patterns of Renal Tubular Disorders in Egyptian Children: a Single Center Study
    Actual Study Start Date :
    Apr 23, 2021
    Actual Primary Completion Date :
    Dec 9, 2021
    Actual Study Completion Date :
    Jan 7, 2022

    Outcome Measures

    Primary Outcome Measures

    1. weight [1 years]

      in kilograms

    2. Glomerular function [1 years]

      The glomerular function was assessed by estimated glomerular filtration rate (eGFR) calculated using Schwartz formula. Chronic kidney disease (CKD) was defined in the presence of a permanent reduction in GFR (e-GFR; <60 ml/min/1.73 m2 Kidney Disease Outcomes Quality Initiative < stage 3).

    3. height [1 years]

      in meters

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    1 Month to 18 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • All children aged from one month to 18 years who have renal tubular disorders.
    Exclusion Criteria:
    • Children who have renal tubular disorders secondary to drugs, intoxication, obstructive uropathy or transient in nature.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 pediatric department, Sohag university hospital Sohag Egypt 82516

    Sponsors and Collaborators

    • Sohag University

    Investigators

    None specified.

    Study Documents (Full-Text)

    More Information

    Publications

    None provided.
    Responsible Party:
    Mohamed Ashraf Mohamed, Principal investigator and resident Doctor in Paediatric Department, Sohag University
    ClinicalTrials.gov Identifier:
    NCT04845815
    Other Study ID Numbers:
    • Soh-Med-21-04-04
    First Posted:
    Apr 15, 2021
    Last Update Posted:
    Feb 7, 2022
    Last Verified:
    Apr 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Mohamed Ashraf Mohamed, Principal investigator and resident Doctor in Paediatric Department, Sohag University
    renal tubular disorders
    failure to thrive
    metabolic acidosis
    metabolic alkalosis
    hypokalemia
    Additional relevant MeSH terms:
    Disease

    Study Results

    No Results Posted as of Feb 7, 2022