Resistance Training in Children

Sponsor

University of Kansas Medical Center (Other)

Overall Status

Recruiting

CT.gov ID

NCT06096610

Collaborator

National Strength and Conditioning Association Foundation (Other)

Enrollment

Locations

Arms

Anticipated Duration (Months)

11.7

Patients Per Site

0.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The project is going to examine the effects of resistance exercise training in prepubescent youth on skeletal muscle strength and lipid content.

Condition or Disease	Intervention/Treatment	Phase
Healthy	Other: Resistance exercise training	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

35 participants

Allocation:

Non-Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

The Effects of Resistance Training on Muscle Lipids in Children.

Actual Study Start Date :

Aug 1, 2023

Anticipated Primary Completion Date :

Oct 1, 2024

Anticipated Study Completion Date :

Oct 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Resistance exercise training Participants undergo 24 sessions of resistance exercise training over about 8 weeks.	Other: Resistance exercise training Participants will strength train via linear periodization resistance exercise training.
No Intervention: Control Participants do not perform resistance exercise training.

Arm

Intervention/Treatment

Experimental: Resistance exercise training

Participants undergo 24 sessions of resistance exercise training over about 8 weeks.

Other: Resistance exercise training

Participants will strength train via linear periodization resistance exercise training.

No Intervention: Control

Participants do not perform resistance exercise training.

Outcome Measures

Primary Outcome Measures

Change in the muscular strength of leg extensors, as measured with isotonic strength. [baseline, following the intervention (9 weeks)]
The score will reflect the strength of the leg extensors. The higher score, reflects greater muscular strength.

Secondary Outcome Measures

Change from baseline in thigh muscle cross-sectional area. [baseline, following the intervention (9 weeks)]
Scores are measured cross-sectional area from ultrasound images. The higher score, reflects greater muscle size of the leg extensors.

Other Outcome Measures

Change from baseline in intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy [baseline, following the intervention (9 weeks)]
The score will reflect a concentration. The higher score, reflects more fat in the fibers.
Change from baseline in extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy [baseline, following the intervention (9 weeks)]
The score will reflect a concentration. The higher score, reflects more fat in the fibers.
Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy [baseline, following the intervention (9 weeks)]
The score will reflect a saturation level of fatty acids in the extramyocellular lipid. The higher score, reflects greater fatty acid saturation.
Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy [baseline, following the intervention (9 weeks)]
The score will reflect a saturation level of fatty acids in the intramyocellular lipid. The higher score, reflects greater fatty acid saturation.

Eligibility Criteria

Criteria

Ages Eligible for Study:

8 Years to 10 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy volunteer males and females ages 8 - 10 years.

Exclusion Criteria:

No history or ongoing neuromuscular diseases.
No history or ongoing musculoskeletal injuries.
No history or ongoing disease that effects metabolism.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Hoglund Biomedical Imaging Center	Kansas City	Kansas	United States	66103
2	Exercise and Human Performance Laboratory	Overland Park	Kansas	United States	66213
3	Metabolic and Body Composition Laboratory	Overland Park	Kansas	United States	66213

Sponsors and Collaborators

University of Kansas Medical Center
National Strength and Conditioning Association Foundation

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Trent J. Herda, Ph.D., Professor, University of Kansas Medical Center

ClinicalTrials.gov Identifier:

NCT06096610

Other Study ID Numbers:

STUDY0014990

First Posted:

Oct 24, 2023

Last Update Posted:

Oct 25, 2023

Last Verified:

Oct 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Trent J. Herda, Ph.D., Professor, University of Kansas Medical Center

exercise

muscle cross-sectional area

intramyocellular lipids

extramyocellular lipids

strength

Study Results

No Results Posted as of Oct 25, 2023