Sedation and Ease of Weaning From Mechanical Ventilation
Study Details
Study Description
Brief Summary
Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Daily interruption of sedation Daily interruption of sedation will be done at 7 am daily by stoppage of midazolam infusion |
Drug: Daily interruption of midazolam
daily at 7 am midazolam infusion will be stopped spontaneous breath trial will be done
Other Names:
|
No Intervention: No Sedation No sedation will be given after initiation of mechanical ventilation |
Outcome Measures
Primary Outcome Measures
- duration of mechanical ventilation [first 30 days]
number of days of mechanical ventilation
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Obstructive lung disease
-
Respiratory failure
-
Invasive mechanical ventilation
Exclusion Criteria:
-
Neurological deficit
-
Cognitive dysfunction
-
Extensive malignancy
-
septic Shock
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Emad Zarief Kamel Said | Assiut | Egypt | 71111 |
Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IRB00009917