Comparison of Central and Peripheral Venous Catheters
Study Details
Study Description
Brief Summary
The purpose of this study is to compare the mechanical and infectious complications of peripheral versus central venous catheters in critically ill patients. Group allocation will be performed by randomization.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Critically ill patients require intravenous administration of fluids and drugs. This can be achieved via peripheral or central catheters. Each device is associated with both mechanical and infectious complications. Complications associated with central lines are judged to be more severe. Some patients actually require the insertion of a central line due to the venous toxicity of the drugs or to the necessity of making sure that the infusion is regularly administered (example: high dose catecholamine infusion). Some physicians believe that most Intensive Care Unit (ICU) patients should have a central venous line inserted, whereas others feel that some patients may receive active drugs via a peripheral line in selected instances. No study prospectively compared the feasibility, merits and complications of the two possibilities (i.e., central or peripheral venous line). This study includes patients that can receive either a central or a peripheral line (see inclusion criteria): mainly patients receiving large amounts of fluid, moderate doses of catecholamines or of drugs that may cause venous injury. Patients are randomized to receive either a peripheral or a central venous catheter. Endpoints are the rate of mechanical complications (difficulty in inserting the line, need for repeat insertion attempts, occurrence of arterial puncture, occurrence of pneumothorax) and of infectious complications (local catheter infection or catheter-related bloodstream infection).
Study Design
Outcome Measures
Primary Outcome Measures
- failure to insert line []
- mechanical complications of intravenous line insertion []
- infectious complications of intravenous lines []
Secondary Outcome Measures
- number of cross-overs (due to impossibility of inserting/maintaining a peripheral line) []
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients requiring low to moderate doses of continuous catecholamine administration in the ICU
-
Patients with 2 failed attempts at inserting a peripheral line
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Patients who require daily change of lines
Exclusion Criteria:
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Patients aged less than 18 years
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Pregnancy
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Absolute necessity of central venous access (refractory shock/high dose catecholamine infusion)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Service de Réanimation, Hopital Louis Mourier | Colombes | France | 92700 |
Sponsors and Collaborators
- Assistance Publique - Hôpitaux de Paris
Investigators
- Principal Investigator: Jean-Damien Ricard, MD, Assistance Publique - Hôpitaux de Paris
Study Documents (Full-Text)
None provided.More Information
Publications
- Polderman KH, Girbes AJ. Central venous catheter use. Part 1: mechanical complications. Intensive Care Med. 2002 Jan;28(1):1-17. Epub 2001 Dec 4. Review.
- Polderman KH, Girbes AR. Central venous catheter use. Part 2: infectious complications. Intensive Care Med. 2002 Jan;28(1):18-28. Epub 2001 Nov 29. Review.
- Timsit JF. [Updating of the 12th consensus conference of the Société de Réanimation de langue française (SRLF): catheter related infections in the intensive care unit]. Ann Fr Anesth Reanim. 2005 Mar;24(3):315-22. Review. French.
- LMR1