Resting Postural Tremor in Multiple Sclerosis
Study Details
Study Description
Brief Summary
Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple sclerosis.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The aim of this study is to test whether specially developed accelerometer and gyroscope can differentiate pattern of resting postural tremor in healthy and people with multiple sclerosis.
Spectral analysis and the correlation of the average signal spectra will be computed. Moreover, categorization based on the tremor component according to the maximum likelihood estimation will be done.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patients with multiple sclerosis MS patients will be chosen by an independent neurologist. |
Behavioral: Examination of tremor and upper hand functions
Participants will be only examined. They will not undergo any intervention.
|
| Healthy volunteers Healthy controls will be paired by age and sex with MS patients. |
Behavioral: Examination of tremor and upper hand functions
Participants will be only examined. They will not undergo any intervention.
|
Outcome Measures
Primary Outcome Measures
- Tremor [baseline]
accelerometer (1 m·s-2)
Secondary Outcome Measures
- Hand grip strength [baseline]
Hand dynamometer JAMA
- Hand and arm function [baseline]
Nine Hole Peg Test
- Psychomotor processing speed [baseline]
Coin Rotation Task
Eligibility Criteria
Criteria
Inclusion Criteria:
Group 1:
-
Definite diagnosis of MS
-
prevailed motor deficit of upper extremities, but without visible tremor
-
stable clinical status in the preceding 3 months
-
Expanded Disability Status Scale score (EDSS) ≥ 2 ≤ 7.5, and
-
no corticosteroid therapy in the preceding month
Group 2:
-
Healthy volunteers in the age of 20-70 years will be employed
-
There will be defined as persons without any neurological disease diagnose at the time of the measurement.
Exclusion Criteria (both groups):
Patients with factors disturbing mobility (e.g. stroke, pregnancy, fractures) were excluded from the study.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of neurology | Prague | Czechia | 100 00 | |
| 2 | Deparment of revmatology and rehabilitation | Prague | Czechia | 140 59 | |
| 3 | Kamila Řasová | Praha | Czechia | 128 00 |
Sponsors and Collaborators
- Charles University, Czech Republic
Investigators
- Principal Investigator: Kamila Řasová, Ph.D., Third Faculty of Mecicine, Charles Univerzity
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- EK-VP/23/0/2014