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Treatment Result of KTP Laser Nasopharyngectomy in Recurrent NPC Patients

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT00364962
Collaborator
(none)
20
Enrollment
1
Location
2
Duration (Months)
10
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Investigate the treatment result of KTP laser nasopharyngectomy in recurrent NPC patients

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Nasopharyngeal carcinomas (NPCs) are highly radiosensitive tumors, and the primary treatment of NPCs is radiotherapy.1 Because most patients who have NPC are at advanced stages when initially seen, local failures in terms of persistence or recurrence are not infrequent after primary radiotherapy.2,3 Local regional relapse without the presence of distant failure can still be salvaged and should be aggressively treated. Tumors relapsing in the nasopharynx can be salvaged using either re-irradiation or surgical techniques.1 Although re-irradiation to the recurrent tumor can extent the 5-year actuarial survival rate, it is associated with high morbidity. 4-6 Traditional nasopharyngectomy has been associated with local control rates on the order of 40%~50%, but it has also been associated with complications such as palatal defects, trismus, facial scarring, osteomyelitis, etc.7-10 That is the reason why surgeons continue searching for new methods for performing nasopharyngectomies with lower morbidities.

    Nasopharyngectomies are difficult to perform because of the inaccessibility of the nasopharynx. More difficulties are encountered in performing a nasopharyngectomy through the nose due to the restricted surgical field. With advances in techniques of endoscopy and application of the potassium-titanyl-phosphate (KTP) laser in surgery, pathologic lesions located either at the choanal margin or in the nasopharynx can easily be managed with instruments inserted via the nasal cavities. The surgical technique had been accepted by the authority journal. This time, we will review the therapeutic result of KTP-laser nasopharyngectomy in patients with recurrent NPC.

    Study Design

    Study Type:
    Observational
    Observational Model:
    Defined Population
    Time Perspective:
    Retrospective
    Study Start Date :
    Apr 1, 2006
    Study Completion Date :
    Jun 1, 2006

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      20 Years to 75 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • recurrent NPC patients
      Exclusion Criteria:
      • patients with distant metastasis

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 National Taiwan University Hospital Taipei Taiwan

      Sponsors and Collaborators

      • National Taiwan University Hospital

      Investigators

      • Principal Investigator: Ching-Ting Tan, MD, PhD, National Taiwan University Hospital

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00364962
      Other Study ID Numbers:
      • 9561703040
      First Posted:
      Aug 16, 2006
      Last Update Posted:
      Aug 16, 2006
      Last Verified:
      Aug 1, 2006
      Keywords provided by , ,
      NPC
      Nasopharyngectomy
      KTP laser
      recurrence
      Additional relevant MeSH terms:
      Nasopharyngeal Carcinoma

      Study Results

      No Results Posted as of Aug 16, 2006