Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning

• Sponsor: University of Aarhus (Other)
• Overall Status: Completed
• CT.gov ID: NCT02898480
• Collaborator: (none)
• Enrollment: 20
• Arm: 1
• Duration (Months): 8

Study Details

Study Description

Brief Summary

Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury. It remains unknown whether this can be used in retinal vascular occlusive diseases. The purpose of the present study is to examine whether the autoregulation of retinal vessel diameters in normal persons change after remote ischemic conditioning.

Condition or Disease	Intervention/Treatment	Phase
Retinal Artery Occlusion; Retinal Vein Occlusion	Procedure: Remote ischemic conditioning	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 20 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning
• Study Start Date: Sep 1, 2016
• Actual Primary Completion Date: Nov 14, 2016
• Actual Study Completion Date: May 1, 2017

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Remote ischemic conditioning	Procedure: Remote ischemic conditioning; Briefly reversible restricting of blood flow to upper limb in four cycles of 5 minutes of inflation at 200mm Hg followed by 5 minutes of deflation.

Outcome Measures

Primary Outcome Measures

1. Diameter change of retinal vessel [immediate]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 35 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Normal persons

Exclusion Criteria:

• Present or previous eye disease

• Use of medications except anti-conceptive

• Epilepsy

• Pregnancy or lactation

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• University of Aarhus

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University of Aarhus
• ClinicalTrials.gov Identifier: NCT02898480
• Other Study ID Numbers: RIK-DVA
• First Posted: Sep 13, 2016
• Last Update Posted: Apr 5, 2019
• Last Verified: Nov 1, 2017

• Additional relevant MeSH terms: Retinal Vein Occlusion; Retinal Artery Occlusion

Study Results

No Results Posted as of Apr 5, 2019